Europen Elderberry + PureWay-C + Zinc Ingredients & Drug Interactions
by Emerald Labs
What is this page for?
First and foremost: checking Europen Elderberry + PureWay-C + Zinc against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Europen Elderberry + PureWay-C + Zinc is a dietary supplement by Emerald Labs with 3 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 270 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are PureWay-C, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Europen Elderberry + PureWay-C + Zinc by Emerald Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Europen Elderberry + PureWay-C + Zinc by Emerald Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Europen Elderberry + PureWay-C + Zinc by Emerald Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains 3 active ingredients. Zinc supports immune function, wound healing, and protein synthesis—it's effective for zinc deficiency and likely effective for Wilson disease (a rare copper-storage disorder).
Vitamin C (supplied as PureWay-C, a bioavailable form) is an antioxidant involved in collagen formation and immune support, and it's effective for vitamin C deficiency. European Elderberry Extract rounds out the formula as a traditional immune-support ingredient, though we hold no interaction data for it.
The capsule itself is the only inactive ingredient.
Does it work?
Moderate evidence
Zinc is effective for treating zinc deficiency and likely effective for Wilson disease. It's rated possibly effective for acne, a rare inherited skin condition called acrodermatitis enteropathica, age-related macular degeneration, and diabetes—meaning some evidence exists but it's not conclusive.
Vitamin C is effective for vitamin C deficiency and possibly effective for anemia of chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections. The effectiveness of European Elderberry Extract is not established in the data we hold.
How safe is it?
Well-documented data
Zinc is generally well tolerated at recommended doses but can cause nausea, diarrhea, abdominal cramps, and a metallic taste—usually dose-related. The safe upper limit for adults is 40 mg daily; high doses above that may raise the risk of copper deficiency over time.
In pregnancy, zinc is rated likely safe; in breastfeeding, it's also rated likely safe. Vitamin C is generally safe at normal doses but can cause nausea, heartburn, diarrhea, and headache—especially above 2 grams daily.
Very high doses may increase kidney stone risk in susceptible people. Vitamin C is rated likely safe in pregnancy and lactation overall, though high-dose supplements in pregnancy are possibly unsafe.
Safety data for European Elderberry Extract in pregnancy and lactation is not on file.
Meds to double-check
Moderate interaction found
Check before combining this product if you take quinolone antibiotics (like ciprofloxacin), tetracycline antibiotics (like doxycycline), cephalexin, estrogens (birth control or hormone therapy), warfarin (a blood thinner), levothyroxine (thyroid medication), penicillamine (a chelation drug), ritonavir (an HIV medication), integrase inhibitors (HIV drugs), or certain chemotherapy agents. All of these have documented moderate-severity interactions with zinc or vitamin C.
Separate antibiotics from this supplement by 2–6 hours as directed.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This combination may appeal to you if you're looking for immune support and have a documented zinc or vitamin C deficiency. Be cautious if you take antibiotics (especially quinolones, tetracyclines, or cephalosporins), blood thinners, thyroid medication, birth control, or HIV drugs—all warrant a conversation with your doctor or pharmacist before adding this supplement.
Keep doses reasonable and talk with your own healthcare provider about whether it fits your health profile.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Europen Elderberry + PureWay-C + Zinc, straight from the product label.
| Brand | Emerald Labs |
|---|---|
| Barcode (UPC) | 743650003600 |
| Net contents | 60 Vegetable Cap(s) |
| Market status | On market |
| Date entered into DSLD | Feb 22, 2024 |
| DSLD ID | 302599 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Europen Elderberry + PureWay-C + Zinc by Emerald Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Zinc | 10 mg | 91% |
| PureWay-C | 300 mg | 333% |
| European Elderberry Extract | 500 mg | -- |
Other ingredients: Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Therapeutic amounts of superior European Elderberry (10:1), 100% Pure, “Gold Standard” Albion Zinc as glycinate Chelate, and Non-GMO Project Verified PureWay-C (12-Hour Retention) for maximum bioavailability.
European elderberry +PureWay-C +Zinc
Albion
General Statements
Emerald Labs is family owned and operated since our beginnings in 1996.
Doctor-formulated
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Emerald Labs The additive-free company
Copyright 2020 Emerald Labs, Inc.
Albion and TRAACS are registered trademarks of Albion Laboratories, Inc. U.S. Patent7,838,042 is licensed by Albion Laboratories, Inc. PureWay-C is a registered trademark of Innovation laboratories, Inc.
Formulation
Enhanced liposomal absorption European & gold-standard
Clinical potency
Made with Non-GMO ingredients NO magnesium stearate Gluten-free
Vegan formula
This product is free of: Milk, Salt, Yeast, Soy, Wheat and Artificial Flavors.
We are committed to providing your family with additive-free formulas and superior nutrient forms in therapeutic amounts.
FDA Statement of Identity
Dietary Supplement
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Adults, take two to four (2-4) capsules daily, split throughout the day, or as directed by a Health Care Practitioner.
Precautions
Keep Out of Reach of Children.
Do not use if safety seal on cap or printed inner seal is missing or broken.
Consult a physician if pregnant, lactating, currently on prescription medication or diagnosed with a medical condition.
Product is manufactured in a facility that processes milk, egg, soy, tree nuts, fish and shellfish.
Storage
Store in a Cool, Dry Place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Europen Elderberry + PureWay-C + Zinc by Emerald Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Europen Elderberry + PureWay-C + Zinc by Emerald Labs
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Zinc
Interacts with67 drugs
Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...
Zinc monograph & interactionsPureWay-C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
PureWay-C monograph & interactionsEuropean Elderberry Extract
Other (inactive) ingredients: Capsule. These complete the product’s ingredient list but are not active constituents.
Europen Elderberry + PureWay-C + Zinc by Emerald Labs Drug Interactions
HelloPharmacist Interaction Report
Emerald Labs Europen Elderberry + PureWay-C + Zinc has documented interactions through its zinc and vitamin C content.
The most serious concern is moderate-severity: zinc can reduce levels of quinolone antibiotics (like ciprofloxacin), tetracycline antibiotics (like doxycycline), cephalexin, and several other drug classes by forming complexes in your gut that block absorption of both the drug and the mineral. If you take any of these antibiotics, separate them from this supplement by at least 2–6 hours, depending on the antibiotic.
Read the full breakdown — every affected drug type, severity by severity
Vitamin C in this product may also moderately interact with estrogens (including birth control pills and hormone therapy), warfarin (a blood thinner), levothyroxine (thyroid medication), certain chemotherapy drugs, and a few others—usually by changing how your body absorbs or processes them. Zinc poses additional moderate interactions with HIV medications (ritonavir, integrase inhibitors, bictegravir combinations), penicillamine (a chelation therapy drug), and theoretically cisplatin (a chemotherapy agent).
We could not check the European Elderberry Extract because we hold no data for it. Altogether, these interactions span 270 individual medications.
Use the medication checker on this page to look up your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Europen Elderberry + PureWay-C + Zinc?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Europen Elderberry + PureWay-C + Zinc interact with 270 drugs. Click any drug to see the details.
2 of the 3 ingredients in Europen Elderberry + PureWay-C + Zinc interact with drugs. Each result below shows which ingredient is responsible. PureWay-C Zinc
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Alginic Acid, Aluminum Hydroxide interactionAltretamineHexalen
How Altretamine interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Altretamine interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum, Aspirin Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Pureway-c + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincTetracycline Antibiotics Moderate
Interaction Summary
Zinc might reduce levels of tetracycline antibiotics.
Read the full Zinc + Amphotericin, Tetracycline interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAluminum, Aspirin Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Pureway-c + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cEstrogens Moderate
Interaction Summary
Vitamin C might increase blood levels of estrogens.
Read the full Pureway-c + Bazedoxifene Acetate, Conjugated Estrogens interactionBendamustineBelrapzo, Treanda, Vivimusta
How Bendamustine interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Bendamustine interactionBendamustine HydrochlorideBendeka
How Bendamustine Hydrochloride interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Bendamustine Hydrochloride interactionBictegravir, Emtricitabine, Tenofovir AlafenamideBiktarvy
How Bictegravir, Emtricitabine, Tenofovir Alafenamide interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Read the full Zinc + Bictegravir, Emtricitabine, Tenofovir Alafenamide interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincTetracycline Antibiotics Moderate
Interaction Summary
Zinc might reduce levels of tetracycline antibiotics.
Read the full Zinc + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBleomycinBlenoxane
How Bleomycin interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAntitumor Antibiotics Moderate
Interaction Summary
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
Read the full Pureway-c + Bleomycin interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Busulfan interactionCarboplatinParaplatin
How Carboplatin interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Carboplatin interactionCarmustineBiCNU, Gliadel, Gliadel Wafer
How Carmustine interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Carmustine interactionCephalexinCephalex, Keflex, Keftab, Lexin
How Cephalexin interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincCephalexin (keflex) Moderate
Interaction Summary
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
Read the full Zinc + Cephalexin interactionChlorambucilLeukeran
How Chlorambucil interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
Pureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Chlorambucil interactionChlortetracyclineAureomycin
How Chlortetracycline interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincTetracycline Antibiotics Moderate
Interaction Summary
Zinc might reduce levels of tetracycline antibiotics.
Read the full Zinc + Chlortetracycline interactionCinoxacinCinobac
How Cinoxacin interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Ciprofloxacin interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Europen Elderberry + PureWay-C + Zinc — through 2 ingredients. Tap an ingredient for the detail:
ZincCisplatin (platinol-aq) Moderate
Interaction Summary
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Read the full Zinc + Cisplatin interactionPureway-cAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Pureway-c + Cisplatin interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Europen Elderberry + PureWay-C + Zinc — through 1 ingredient. Tap an ingredient for the detail:
ZincQuinolone Antibiotics Moderate
Interaction Summary
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Read the full Zinc + Clinafloxacin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Europen Elderberry + PureWay-C + Zinc with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
PureWay-C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Zinc
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.
Cephalexin (Keflex)
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.
Cisplatin (Platinol-Aq)
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.
Integrase Inhibitors
Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.
Penicillamine (Cuprimine, Depen)
Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.
Quinolone Antibiotics
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.
Ritonavir (Norvir)
Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.
Tetracycline Antibiotics
Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.
Amiloride (Midamor)
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.
Atazanavir (Reyataz)
Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.
Brand information
Manufacturer and brand details for Europen Elderberry + PureWay-C + Zinc, from the product label.
Emerald Labs
See all Emerald Labs products- Name
- Emerald Labs
- City
- Carson
- State
- CA
- Phone Number
- 800-436-4366
- Web Address
- www.emeraldlabs.com
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The Full Monographs Behind Europen Elderberry + PureWay-C + Zinc’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Zinc
Interacts with 67 drugsZinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...
Read the full Zinc monograph → Herb & supplement monographVitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph →Sources & How We Checked
Europen Elderberry + PureWay-C + Zinc's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 139 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Zinc 88 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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