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Dietary supplement

Expectorant Formula 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Expectorant Formula 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Expectorant Formula 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Expectorant Formula 450 mg is a dietary supplement by TerraVita Premium Collection with 6 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 1,283 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Licorice, Eucalyptus, Buckthorn. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Expectorant Formula 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Expectorant Formula 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Expectorant Formula 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (450 mg) without saying how much of each component you get.

This formula contains 6 active ingredients: lemon balm, licorice, buckthorn (sea buckthorn), linden, eucalyptus, and poppy seed, each contributing different properties. Lemon balm and licorice are the primary components; buckthorn, linden, and eucalyptus round out the blend.

The capsules also contain gelatin and water as inactive ingredients. Lemon balm is included for its traditional use in managing stress and cold sores; licorice for skin conditions and minor inflammation; buckthorn for general wellness; linden for its calming properties; eucalyptus for respiratory support; and poppy seed as a traditional cough remedy.

All are presented in capsule form for easy dosing.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: respiratory congestion and cough relief.
  • We looked for evidence on: Bronchitis, Chronic bronchitis, Common cold, Cough, Influenza, chest congestion — and 2 related terms.
  • The closest evidence on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Eucalyptus is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Cough, Influenza.
  • Also on file: Sea Buckthorn is rated "Insufficient Reliable Evidence To Rate" for Common cold.

The evidence supporting these ingredients is limited. Lemon balm is possibly effective for cold sores and stress relief, and possibly effective for mood support.

Licorice is possibly effective for atopic dermatitis (eczema) and canker sores, though the evidence for Addison disease and asthma is insufficient. Buckthorn is possibly effective for burns but possibly ineffective for eczema; evidence for its effects on cholesterol, aging skin, and cancer is insufficient.

Linden, eucalyptus, and poppy seed all lack established evidence in our data — eucalyptus effectiveness for acne, bronchitis, asthma, and other conditions is insufficient, and poppy seed's use for cough and insomnia is not well established. If you're taking this for a specific condition, talk with your doctor or pharmacist about whether the evidence supports its use for your needs.

The evidence, ingredient by ingredient Lemon Balm Licorice Sea Buckthorn Linden Eucalyptus Poppy Seed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use; dizziness and sedation have been reported but do not appear more common than placebo, and combining it with alcohol does not affect reaction time. One isolated case of heart rhythm problems was reported with a multi-ingredient product containing lemon balm, though it's unclear if lemon balm alone was responsible.

Licorice is well tolerated at food amounts but can cause serious problems at high doses or with long-term use — common side effects include headache, nausea, and vomiting. Buckthorn is generally well tolerated as food but may cause yellow skin staining at high doses; topical use can cause dryness and rash.

Linden has limited human safety data; one case of allergic reaction to linden pollen tea and one case of contact skin reaction have been reported. Eucalyptus is safe in small amounts for inhalation or diluted topical use, but undiluted oil is toxic if swallowed and has caused seizures in both children and adults; common oral side effects include nausea, vomiting, and diarrhea, and topical use may cause burning and itching.

Poppy seed is safe in food amounts but large amounts contain trace opiate residue that may cause allergic reactions or positive drug tests.

Side effects, ingredient by ingredient Lemon Balm Licorice Sea Buckthorn Linden Eucalyptus Poppy Seed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Lemon Balm, Linden, Eucalyptus, Sea Buckthorn, Licorice.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,284 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take digoxin (heart medication), blood thinners like warfarin, loop diuretics, lithium, thyroid hormone, sedating medications, diabetes drugs, blood pressure medications, or any drug broken down by your liver. All of these have moderate-severity interactions with one or more ingredients here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This formula blends six traditional herbal ingredients with limited to modest evidence for their claimed effects. If you take any prescription medication — especially heart, blood pressure, blood-thinning, diabetes, or psychiatric drugs, or anything processed by your liver — run your full medication list through the interaction checker on this page before starting.

Talk with your doctor or pharmacist about whether this supplement fits your situation and whether the evidence supports its use for what you're hoping it will do.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Expectorant Formula 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435168889
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 290051
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Expectorant Formula 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435168889
IngredientAmount% DV
Proprietary Blend450 mg--
Lemon Balm0 NP--
Licorice0 NP--
Buckthorn0 NP--
Linden0 NP--
Eucalyptus0 NP--
Poppy Seed0 NP--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Linden, eucalyptus, lemon balm and more

FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2006 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule, 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Expectorant Formula 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Expectorant Formula 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Expectorant Formula 450 mg by TerraVita Premium Collection

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

450 mg per serving

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Expectorant Formula 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Expectorant Formula 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,283Drugs
1,281 Moderate 2 Minor

Ingredients driving the most interactions

Licorice 1,040
Eucalyptus 878
Buckthorn 289
Lemon Balm 264
Linden 1

Individual Drug Interactions

The ingredients in Expectorant Formula 450 mg interact with 1,283 drugs. Click any drug to see the details.

5 of the 6 ingredients in Expectorant Formula 450 mg interact with drugs. Each result below shows which ingredient is responsible. Licorice Eucalyptus Buckthorn Lemon Balm Linden

Each ingredient & the kinds of drugs it affects

For each ingredient in Expectorant Formula 450 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Licorice18 drug types · 1,040 drugs

Antihypertensive Drugs

Theoretically, licorice might reduce the effects of antihypertensive drugs.
In human research, licorice increases blood pressure in a dose-dependent manner.

Likelihood Possible Evidence B
Cisplatin (Platinol-Aq)

Theoretically, licorice might reduce the effects of cisplatin.
In animal research, licorice diminished the therapeutic efficacy of cisplatin.

Likelihood Possible Evidence D
Corticosteroids

Theoretically, concomitant use of licorice and corticosteroids might increase the side effects of corticosteroids.
Case reports suggest that concomitant use of licorice and oral corticosteroids, such as hydrocortisone, can potentiate the duration of activity and increase blood levels of corticosteroids. Additionally, in one case report, a patient with neurogenic orthostatic hypertension stabilized on fludrocortisone 0.1 mg twice daily developed pseudohyperaldosteronism after recent consumption of large amounts of black licorice.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2B6.
In vitro research shows that licorice extract and glabridin, a licorice constituent, inhibit CYP2B6 isoenzymes. Licorice extract from the species G. uralensis seems to inhibit CYP2B6 isoenzymes to a greater degree than G. glabra extract in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2B6; however, these interactions have not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C19.
In vitro, licorice extracts from the species G. glabra and G. uralensis inhibit CYP2C19 isoenzymes in vitro. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C19; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, licorice might increase levels of drugs metabolized by CYP2C8.
In vitro, licorice extract from the species G. glabra and G. uralensis inhibits CYP2C8 isoenzymes. Theoretically, these species of licorice might increase levels of drugs metabolized by CYP2C8; however, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP2C9.
There is conflicting evidence about the effect of licorice on CYP2C9 enzyme activity. In vitro research shows that extracts from the licorice species G. glabra and G. uralensis moderately inhibit CYP2C9 isoenzymes. However, evidence from an animal model shows that licorice extract from the species G. uralensis can induce hepatic CYP2C9 activity. Until more is known, licorice should be used cautiously in people taking CYP2C9 substrates.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.
Pharmacokinetic research shows that the licorice constituent glycyrrhizin, taken in a dosage of 150 mg orally twice daily for 14 days, modestly decreases the area under the concentration-time curve of midazolam by about 20%. Midazolam is a substrate of CYP3A4, suggesting that glycyrrhizin modestly induces CYP3A4 activity. Animal research also shows that licorice extract from the species G. uralensis induces CYP3A4 activity. However, licorice extract from G. glabra species appear to inhibit CYP3A4-induced metabolism of testosterone in vitro. It is thought that the G. glabra inhibits CYP3A4 due to its constituent glabridin, which is a moderate CYP3A4 inhibitor in vitro and not present in other licorice species. Until more is known, licorice should be used cautiously in people taking CYP3A4 substrates.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Theoretically, concomitant use of licorice with digoxin might increase the risk of cardiac toxicity.
Overuse or misuse of licorice with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of licorice with diuretic drugs might increase the risk of hypokalemia.
Overuse of licorice might compound diuretic-induced potassium loss. In one case report, a 72-year-old male with a past medical history of hypertension, type 2 diabetes, hyperlipidemia, arrhythmia, stroke, and hepatic dysfunction was hospitalized with severe hypokalemia and uncontrolled hypertension due to pseudohyperaldosteronism. This was thought to be provoked by concomitant daily consumption of a product containing 225 mg of glycyrrhizin, a constituent of licorice, and hydrochlorothiazide 12.5 mg for 1 month.

Likelihood Possible Evidence D
Estrogens

Theoretically, licorice might increase or decrease the effects of estrogen therapy.
Theoretically, licorice might interfere with estrogen therapy due to estrogenic and anti-estrogenic effects.

Likelihood Possible Evidence D
Loop Diuretics

Theoretically, loop diuretics might increase the mineralocorticoid effects of licorice.
Theoretically, loop diuretics might enhance the mineralocorticoid effects of licorice by inhibiting the enzyme that converts cortisol to cortisone; however, bumetanide (Bumex) does not appear to have this effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, licorice might decrease levels of midazolam.
In humans, the licorice constituent glycyrrhizin appears to moderately induce the metabolism of midazolam. This is likely due to induction of cytochrome P450 3A4 by licorice. Until more is known, licorice should be used cautiously in people taking midazolam.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, licorice might decrease the absorption of P-glycoprotein substrates.
In vitro research shows that licorice can increase P-glycoprotein activity.

Likelihood Possible Evidence D
Paclitaxel (Abraxane, Onxol)

Theoretically, licorice might decrease plasma levels and clinical effects of paclitaxel.
Multiple doses of licorice taken concomitantly with paclitaxel might reduce the effectiveness of paclitaxel. Animal research shows that licorice 3 grams/kg given orally for 14 days before intravenous administration of paclitaxel decreases the exposure to paclitaxel and increases its clearance. Theoretically, this occurs because licorice induces cytochrome P450 3A4 enzymes, which metabolize paclitaxel. Notably, a single dose of licorice did not affect exposure or clearance of paclitaxel.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, licorice might decrease plasma levels and clinical effects of warfarin.
Licorice seems to increase metabolism and decrease levels of warfarin in animal models. This is likely due to induction of cytochrome P450 2C9 (CYP2C9) metabolism by licorice. Advise patients taking warfarin to avoid taking licorice.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, licorice might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that licorice induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Theoretically, licorice might increase levels of methotrexate.
Animal research suggests that intravenous administration of glycyrrhizin, a licorice constituent, and high-dose methotrexate may delay methotrexate excretion and increase systemic exposure, leading to transient elevations in liver enzymes and total bilirubin. This interaction has not yet been reported in humans.

Likelihood Unlikely Evidence D
Licorice full monograph & interactions

Eucalyptus7 drug types · 878 drugs

Amphetamines

Theoretically, inhaling eucalyptol may reduce the effectiveness of amphetamines.
Animal research suggests that inhaling eucalyptol may reduce the levels of amphetamines in the blood.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, eucalyptus leaf might increase the risk of hypoglycemia.
Animal research suggests that eucalyptus leaf might have hypoglycemic activity, and might have additive effects when used with antidiabetes drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, eucalyptus might increase the levels of CYP1A2 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP1A2, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C19 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, eucalyptus might increase the levels of CYP2C9 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, eucalyptus might increase the levels of CYP3A4 substrates.
In vitro research suggests that eucalyptus oil might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, inhaling eucalyptol might reduce the effectiveness of pentobarbital.
Animal research suggests that inhaling eucalyptol reduces the level of pentobarbital that reaches the brain.

Likelihood Possible Evidence D
Eucalyptus full monograph & interactions

Buckthorn2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sea buckthorn may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that sea buckthorn fruit extracts can inhibit platelet aggregation and adhesion to collagen and fibrinogen.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking sea buckthorn with antihypertensive drugs might increase the risk of hypotension.
Taking sea buckthorn appears to reduce blood pressure in some patients.

Likelihood Possible Evidence D
Buckthorn full monograph & interactions

Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm full monograph & interactions

Linden1 drug type · 1 drug

Lithium

Theoretically, due to its potential diuretic effects, linden might increase the effects and adverse effects of lithium.
Linden is thought to have diuretic properties. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Linden full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Expectorant Formula 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Expectorant Formula 450 mg by TerraVita Premium Collection: Common Questions

Does Expectorant Formula 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Expectorant Formula 450 mg has a known interaction with 1,283 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Expectorant Formula 450 mg contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy?
Licorice should be avoided in pregnancy — the evidence advises against it. Lemon balm, buckthorn, linden, eucalyptus, and poppy seed don't have enough safety data during pregnancy to say either way. Talk with your doctor before using this product if you're pregnant or planning to become pregnant; they can weigh your individual situation.
Is this safe while breastfeeding?
Safety data while breastfeeding are limited for all ingredients except eucalyptus, which is likely safe in small amounts. Licorice is best avoided due to insufficient data. For lemon balm, buckthorn, linden, and poppy seed, there isn't enough information to know either way. Check with your doctor or pharmacist before use.
What is lemon balm supposed to do?
Lemon balm is possibly effective for cold sores and for easing stress and low mood. The evidence is modest, so it's not guaranteed to work for everyone. It may cause dizziness or sedation in some people, though these effects don't appear more common than placebo in clinical trials.
Can this help with a cough?
Eucalyptus and poppy seed are traditional cough remedies, but we don't have strong evidence that either works for cough in our data. If you have a persistent cough, talk with your doctor to find out what's causing it and whether this supplement is the right choice.
Will this stain my skin yellow?
Buckthorn (sea buckthorn) at high doses may cause yellow staining of the skin. One case was reported in someone who ate 100 grams daily for 6 months. At normal supplement doses, this risk is lower, but it's possible.
Why does this product have so many interactions?
Licorice and eucalyptus in particular affect how your liver breaks down many different medications, and licorice also interacts with specific heart and blood-thinning drugs. Even though it's a short ingredient list, each ingredient can touch multiple drug pathways. That's why it's important to check your full medication list before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Expectorant Formula 450 mg label
Go deeper

The Full Monographs Behind Expectorant Formula 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Licorice

Interacts with 1,040 drugs

Licorice root is a traditional remedy used for sore throats, coughs, and digestive complaints, but solid human evidence is limited for most uses. Regular licorice contains glycyrrhizin, whic...

Read the full Licorice monograph → Herb & supplement monograph

Sea Buckthorn

Interacts with 289 drugs

Sea buckthorn is a berry-bearing shrub rich in vitamins, carotenoids, and fatty acids that people use for skin, eye, digestive, and heart health. Early research is promising for a few uses l...

Read the full Sea Buckthorn monograph → Herb & supplement monograph

Linden

Interacts with 1 drug

Linden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evidence for these uses is lacking, but the...

Read the full Linden monograph → Herb & supplement monograph

Eucalyptus

Interacts with 878 drugs

Eucalyptus is best known for its strong-smelling oil used in vapor rubs, inhalants, and lozenges to ease coughs and congestion. It may provide mild, short-term relief of cold symptoms, but t...

Read the full Eucalyptus monograph → Herb & supplement monograph

Poppy Seed

Poppy seeds are a common food ingredient harvested from the opium poppy, and the seeds themselves contain very little of the plant's opium compounds. They are generally safe as food, but eat...

Read the full Poppy Seed monograph →
Sources

Sources & How We Checked

Expectorant Formula 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 149 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
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Poppy Seed 13 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Meneely KD. Poppy seed ingestion: the Oregon perspective. J Forensic Sci 1992;37(4):1158-1162. DOI
  3. Kaplan, R. Poppy seed dependence. Med J Aust 1994;161(2):176. PubMed
  4. Braye, K., Harwood, T., Inder, R., Beasley, R., and Robinson, G. Poppy seed tea and opiate abuse in New Zealand. Drug Alcohol Rev 2007;26(2):215-219. PubMed
  5. Lloyd-Jones, D. M. and Bonomo, Y. Unusual presentations for pharmacotherapy-poppy seed dependence. Drug Alcohol Rev 2006;25(4):375-376. PubMed
  6. Braun, W. and Kovary, P. M. [Poppy seed allergy]. Z.Hautkr 1988;63(4):344.
  7. Pettitt BC Jr, Dyszel SM, Hood LV. Opiates in poppy seed: effect on urinalysis results after consumption of poppy seed cake-filling. Clin Chem 1987;33(7):1251-2. DOI
  8. Bjerver K, Jonsson J, Kilsson A. Morphine intake from poppy seed food. J Pharma Pharmacol 2011;34(12):798-801. DOI
  9. Facchini PJ, De Luca V. Phloem-Specific Expression of Tyrosine/Dopa Decarboxylase Genes and the Biosynthesis of Isoquinoline Alkaloids in Opium Poppy. The Plant Cell 1995;7(11):1811-1821. PubMed
  10. Powers D, Erickson S, Swortwood MJ. Quantification of morphine, codeine, and thebaine in home-brewed poppy seed tea by LC-MS/MS. J Forensic Sci. 2018;63(4):1229-1235.
  11. Schuppener LM, Corliss RF. Death due to complications of bowel obstruction following raw poppy seed ingestion. J Forensic Sci. 2018;63(2):614-618. PubMed
  12. Poponea N, Kashlan MT, Vollstaedt J. Opium poppy seed tea: A lesser known but deadly cocktail. Am J Respir Crit Care Med. 2018;197:A6895.
  13. Tan YPA, Alexander PDG, Knowles S. Acute cardiotoxicity following 'poppy seed tea' consumption. Anaesth Rep 2021;9(2):e12130. PubMed

See these in context on the Poppy Seed monograph →

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