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Dietary supplement

Extra Strength Serrapeptase Ingredients & Drug Interactions

by Zazzee Naturals

Extra Strength Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra Strength Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extra Strength Serrapeptase is a dietary supplement by Zazzee Naturals with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Extra Strength Serrapeptase by Zazzee Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Serrapeptase by Zazzee Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Extra Strength Serrapeptase by Zazzee Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: serrapeptase, a proteolytic enzyme — a protein that breaks down other proteins. It's derived from the digestive secretions of the silkworm.

The capsule also includes inactive ingredients: hypromellose (a film-coating polymer), rice powder, magnesium stearate (a lubricant), and silica.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support normal respiratory health and immune function.
  • We looked for evidence on: Asthma, Chronic bronchitis, Laryngitis, Pharyngitis, Rhinosinusitis, Bronchiectasis — and 2 related terms.
  • The closest evidence on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Chronic bronchitis (Natural Medicines).
  • Also on file: Serrapeptase is rated "Insufficient Reliable Evidence To Rate" for Asthma, Pharyngitis, Rhinosinusitis, Bronchiectasis, and more.

The evidence for serrapeptase is limited. Our data shows insufficient reliable evidence to rate it for chronic bronchitis, asthma, atherosclerosis, back pain, or osteoporosis.

That means the studies we have aren't robust enough yet to say whether it works for these uses. If you're considering it for a specific condition, talk with your pharmacist or doctor about what the current evidence actually supports.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated in the short term, though long-term safety hasn't been thoroughly studied. The most common side effects reported are epigastric pain (discomfort in the upper abdomen), general gastrointestinal upset, and nausea — though in trials these occurred about as often as placebo.

Bullous pemphigoid, a rare blistering skin condition, has been reported. The safety data advises against using this product during pregnancy or while breastfeeding.

If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor before taking it.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your exact medications if you use any blood thinners or antiplatelet drugs — including warfarin, aspirin, clopidogrel, or similar medications. This is a Moderate-severity interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is generally well tolerated short-term, but the evidence for what it actually treats is still thin. The main concern is its potential to increase bleeding risk when paired with blood thinners or antiplatelet drugs.

If you take any of those medications, check with us or your pharmacist before starting. Long-term safety isn't well established, and it's not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra Strength Serrapeptase, straight from the product label.

Brand Zazzee Naturals
Barcode (UPC) X00327O8S9
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318715
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra Strength Serrapeptase by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Delayed Release Capsule(s)
Maximum serving Sizes:
1 Delayed Release Capsule(s)
Servings per container
120
UPC/BARCODE
X00327O8S9
IngredientAmount% DV
Serrapeptase0 NP--

Other ingredients: Hypromellose, Rice, Powder, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 capsule daily on an empty stomach with at least 8 ounces of water. For best results, avoid eating for 30 minutes after use. Continuous use of this product for more than 30 days is not recommended except under the supervision of a healthcare practitioner.

Formula

Zazzee Naturals Extra Strength Serrapeptase is a systemic enzyme commonly used to support normal respiratory health and healthy immune function. Zazzee Extra Strength Serrapeptase delivers a potent dose of 120,000 SPU in delayed release capsules, which helps the enzymes survive the stomach acid and pass into the small intestine.

Extra Strength Serrapeptase Systemic Enzymes 120,000 SPU per capsule

Precautions

Warning: For adults only. Keep out of reach of children.

Do not use if you are pregnant or nursing. Consult physician if taking medication (especially blood thinning medications or if you are taking any drug that affects blood coagulation such as prescription Vitamin K, heparin, warfarin or aspirin), if you suffer from any gastrointestinal disorders such as ulcers, or have any other medical condition.

Discontinue use if you experience nausea, diarrhea, vomiting or stomach upset, or if other intestinal discomfort occurs. Not for long-term use except under the supervision of a physician.

Allergen information: Not manufactured with wheat, corn, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Do not eat freshness packet.

Formulation

Supports healthy immune function Delayed release for maximum absorption Supports normal respiratory health

Allergen information: Not manufactured with wheat, corn, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Made with Non GMO ingredients

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place after opening. Do not eat freshness packet. Keep in bottle.

General Statements

Please recycle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality Made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra Strength Serrapeptase by Zazzee Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra Strength Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra Strength Serrapeptase by Zazzee Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Delayed Release Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
0 NP per serving

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice, Powder, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra Strength Serrapeptase by Zazzee Naturals Drug Interactions

Want to check YOUR meds against Extra Strength Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Extra Strength Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Extra Strength Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra Strength Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra Strength Serrapeptase, from the product label.

Zazzee Naturals

See all Zazzee Naturals products
Name
Zazzee Naturals
Street Address
400 Rella Boulevard Suite 123 Dept. 182
City
Montebello
State
NY
ZipCode
10901
Web Address
ZazzeeNaturals.com
Pharmacist Counseling Corner

Extra Strength Serrapeptase by Zazzee Naturals: Common Questions

Does Extra Strength Serrapeptase by Zazzee Naturals interact with any medications?
Yes. Based on its ingredients, Extra Strength Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra Strength Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is serrapeptase and what does it do?
Serrapeptase is a proteolytic enzyme — a protein that breaks down other proteins — derived from the digestive system of silkworms. It has fibrinolytic activity, meaning it helps break down fibrin, a protein involved in blood clotting. It's used in this supplement for a variety of claimed health purposes, though the evidence is still limited.
Does serrapeptase actually work for back pain, asthma, or bronchitis?
Our data shows insufficient reliable evidence to say whether serrapeptase helps any of these conditions — including back pain, asthma, atherosclerosis, chronic bronchitis, and osteoporosis. The studies so far haven't been robust enough to confirm it works. Talk with your doctor or pharmacist about whether it's worth trying for your situation.
What are the side effects?
Most commonly, people report epigastric pain (discomfort in the upper abdomen), gastrointestinal upset, and nausea — though in trials these happened about as often as placebo. Bullous pemphigoid, a rare blistering skin condition, has been reported. Long-term safety hasn't been well studied.
Is it safe to take during pregnancy or while breastfeeding?
No. The safety data advises against using serrapeptase during pregnancy and while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk with your pharmacist or doctor first.
Can I take this with aspirin or other blood thinners?
That's a question for your pharmacist or doctor — serrapeptase may theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel. Use the medication checker on this page or ask us to review your specific medications before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra Strength Serrapeptase is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra Strength Serrapeptase label
Go deeper

The Full Monographs Behind Extra Strength Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Extra Strength Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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