Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Fermented Beta Glucans Ingredients & Drug Interactions

by Dr. Mercola

Fermented Beta Glucans label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fermented Beta Glucans against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fermented Beta Glucans is a dietary supplement by Dr. Mercola with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, heart health, immune support.Based on those ingredients, 293 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Beta-Glucan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fermented Beta Glucans by Dr. Mercola

Ask about any prescription or over-the-counter medication and we check it for interactions with Fermented Beta Glucans by Dr. Mercola — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fermented Beta Glucans by Dr. Mercola

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “fermented Euglena” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

This product contains 2 active ingredients. Beta-glucan is the main one — a soluble fiber derived from yeast and other sources that's been studied for heart and cholesterol health.

The other active is fermented Euglena, a microorganism that's been fermented to create its active compounds. The rest — hydroxypropyl methylcellulose and rice hulls — are inactive ingredients that hold the capsule together and help it dissolve.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Beta-glucans's overall clinical evidence instead.

Strong

Strong clinical evidence supports Beta-glucans for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Natural Medicines).
  • On file: Dyslipidemia — rated "Likely Effective" (Natural Medicines).

Beta-glucans in this product are rated Likely Effective for two purposes: lowering cholesterol and triglycerides (dyslipidemia) and supporting heart health (coronary heart disease). That's solid evidence from clinical research.

We don't have effectiveness data on file for the fermented Euglena ingredient itself.

The evidence, ingredient by ingredient Beta-glucans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-glucans from food sources are generally well tolerated. That said, concentrated supplement doses haven't been studied as thoroughly as whole foods, so use some caution.

When applied to skin, beta-glucans can occasionally cause mild contact dermatitis or skin reactions — these were mild and went away on their own in most cases. There's limited research on supplement doses during breastfeeding, so talk with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Beta-glucans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Beta-glucans.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 293 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this if you're on blood pressure medication (Moderate interaction risk — beta-glucans may lower pressure further) or immunosuppressant drugs (Moderate risk — they may work against each other). No interactions are documented for the Yeast Fermentate ingredient because we hold no data for it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This could be worth considering if you're interested in cholesterol and heart support and your doctor agrees it fits your picture. But if you take blood pressure medication or immune-suppressing drugs, you need to check with your pharmacist first — the interactions here are real.

Also, because concentrated doses haven't been studied as much as food sources, caution is smart.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fermented Beta Glucans, straight from the product label.

Brand Dr. Mercola
Barcode (UPC) 810487031547
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 327113
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fermented Beta Glucans by Dr. Mercola, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
810487031547
IngredientAmount% DV
fermented Euglena400 mg--
Yeast Fermentate500 mg--
Beta-Glucan200 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Rice hulls

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults, as a dietary supplement, take one (1) to two (2) capsules daily.

Precautions

Keep out of reach of children.

Do not use if safety seal is broken.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Seals/Symbols

NSF Contents Certified

FDA Statement of Identity

Dietary Supplement

General Statements

Providing quality products since 2001.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fermented Beta Glucans by Dr. Mercola label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fermented Beta Glucans label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fermented Beta Glucans by Dr. Mercola

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fermented Euglena

400 mg per serving

Yeast Fermentate

500 mg per serving Form: Saccharomyces cerevisiae

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Rice hulls. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fermented Beta Glucans by Dr. Mercola Drug Interactions

Want to check YOUR meds against Fermented Beta Glucans?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
293Drugs
293 Moderate

Ingredients driving the most interactions

Beta-Glucan 293

Individual Drug Interactions

The ingredients in Fermented Beta Glucans interact with 293 drugs. Click any drug to see the details.

1 of the 2 ingredients in Fermented Beta Glucans interact with drugs. Each result below shows which ingredient is responsible. Beta-Glucan

Each ingredient & the kinds of drugs it affects

For each ingredient in Fermented Beta Glucans with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Beta-Glucan2 drug types · 293 drugs

Antihypertensive Drugs

Theoretically, taking beta-glucans with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that taking beta-glucans may reduce systolic and diastolic blood pressure in some hypertensive individuals.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, beta-glucans might interfere with immunosuppressive therapy.
Some clinical research shows that beta-glucans have immunostimulant effects.

Likelihood Possible Evidence D
Beta-Glucan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fermented Beta Glucans, from the product label.

Dr. Mercola

See all Dr. Mercola products
Name
NHP
Street Address
125 SW 3rd Place
City
Cape Coral
State
FL
ZipCode
33991
Phone Number
(877) 985-2696
Pharmacist Counseling Corner

Fermented Beta Glucans by Dr. Mercola: Common Questions

Does Fermented Beta Glucans by Dr. Mercola interact with any medications?
Yes. Based on its ingredients, Fermented Beta Glucans has a known interaction with 293 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fermented Beta Glucans contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's fermented Euglena, and why is it in here?
Euglena is a microorganism that's been fermented to create active compounds meant to work alongside the beta-glucans. We don't have specific effectiveness data on file for it, though, so the main proven benefit of this product is from the beta-glucan itself.
Is this safe to take every day?
Beta-glucans from food are well tolerated in regular amounts. The concern is that concentrated supplement doses haven't been studied as thoroughly, so use caution and watch how you feel. If you develop any unusual symptoms, stop and check with your pharmacist.
Can I take this while breastfeeding?
There's not much research on supplement doses during breastfeeding, so the data isn't there to say either way. Talk with your doctor or pharmacist — they can help you weigh the pros and cons for your situation.
Does this really help cholesterol and heart health?
Beta-glucans are rated Likely Effective for both cholesterol and heart health, which means there's solid clinical research backing it. That's the ingredient doing the heavy lifting here.
What side effects should I watch for?
Beta-glucans are generally well tolerated taken by mouth. If applied to skin, mild contact dermatitis or skin reactions can happen but usually go away on their own. We don't have specific side-effect data for the Yeast Fermentate ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fermented Beta Glucans is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fermented Beta Glucans label
Go deeper

The Full Monographs Behind Fermented Beta Glucans’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-glucans

Interacts with 293 drugs

Beta-glucans are natural fibers found in oats, barley, mushrooms, and yeast. The strongest evidence supports the oat and barley types for modestly lowering cholesterol and blood sugar, while...

Read the full Beta-glucans monograph →
Sources

Sources & How We Checked

Fermented Beta Glucans's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-glucans 11 references
  1. Katz, D. L., Nawaz, H., Boukhalil, J., Giannamore, V., Chan, W., Ahmadi, R., and Sarrel, P. M. Acute effects of oats and vitamin E on endothelial responses to ingested fat. Am.J.Prev.Med. 2001;20(2):124-129. PubMed
  2. Keenan, J. M., Pins, J. J., Frazel, C., Moran, A., and Turnquist, L. Oat ingestion reduces systolic and diastolic blood pressure in patients with mild or borderline hypertension: a pilot trial. J.Fam.Pract. 2002;51(4):369.
  3. Maki, K. C., Galant, R., Samuel, P., Tesser, J., Witchger, M. S., Ribaya-Mercado, J. D., Blumberg, J. B., and Geohas, J. Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress i
  4. Bergendiova, K., Tibenska, E., and Majtan, J. Pleuran (beta-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur.J.Appl.Physiol 2011;111(9):2033-2040.
  5. Talbott S, Talbott J. Effect of beta 1,3/1,6 glucan on respiratory tract infection symptoms and mood state in marathon athletes. J Sports Sci Med 2009;8(4):509-515.
  6. Feldman S, Schwartz HI Kalman DS Mayers A Kohrman HM Clemens R Krieger DR. Randomized phase II clinical trials of Wellmune WGP® for immune support during cold and flu season. The Journal of Applied Research 2009;9(1-2):30-42.
  7. McFarlin BK, Carpenter KC, Davidson T, McFarlin MA. Baker's yeast beta glucan supplementation increases salivary IgA and decreases cold/flu symptomatic days after intense exercise. J Diet Suppl. 2013;10(3):171-83. PubMed
  8. Jesenak M, Urbancek S, Majtan J, Banovcin P, Hercogova J. ß-Glucan-based cream (containing pleuran isolated from pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat 2016;27(4):351-4.
  9. Mah E, Kaden VN, Kelley KM, Liska DJ. Beverage containing dispersible yeast ß-glucan decreases cold/flu symptomatic days after intense exercise: a randomized controlled trial. J Diet Suppl 2020;17(2):200-10. PubMed
  10. Zhong K, Liu Z, Lu Y, Xu X. Effects of yeast ß-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis. Eur J Nutr. 2021. PubMed
  11. Cardenas FI, Mauguen A, Cheung IY, et al. Phase I trial of oral yeast-derived ß-glucan to enhance anti-GD2 immunotherapy of resistant high-risk neuroblastoma. Cancers (Basel) 2021;13(24):6265. PubMed

See these in context on the Beta-glucans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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