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Dietary supplement

Fermented Organic Lion's Mane 1000 mg Ingredients & Drug Interactions

by Solaray

Fermented Organic Lion's Mane 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fermented Organic Lion's Mane 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fermented Organic Lion's Mane 1000 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Mushroom, Fermented. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fermented Organic Lion's Mane 1000 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Fermented Organic Lion's Mane 1000 mg by Solaray — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Fermented Organic Lion's Mane 1000 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: fermented lion's mane mushroom at 1000 mg per capsule. Lion's mane is a medicinal fungus traditionally used to support brain and nervous system health.

The mushroom is fermented—a process meant to improve absorption and bioavailability. The capsule itself is made from pullulan, an inactive ingredient that serves as the capsule material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Cognitive support.
  • We looked for evidence on: Cognitive function, Memory, Cognitive impairment, Dementia, Alzheimer disease, Parkinson disease — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Dementia, Memory, and more.

The evidence we hold for lion's mane covers several intended uses—Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment—but all are rated Insufficient Reliable Evidence To Rate. That means we don't have enough solid clinical data yet to say whether the supplement works for these purposes.

If you're considering it for a specific health goal, chat with your pharmacist or doctor about what the current research shows.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated as a food, but long-term safety as a supplement hasn't been studied thoroughly. The most commonly reported side effects in trials are gastrointestinal discomfort, nausea, and skin rash.

The safety data advises against use during pregnancy and while breastfeeding because not enough information exists to know whether it's safe for you or your baby in those situations.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin)—lion's mane may raise bleeding risk. Blood sugar medications and immune-suppressing drugs also need review before you start, since the mushroom may interfere with how they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane may be worth considering if you're interested in brain health support, though the evidence for specific benefits isn't yet well established. If you take blood thinners, diabetes medications, or immune-suppressing drugs, you'll need to check with your pharmacist first.

Talk to us before starting, especially if you're on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fermented Organic Lion's Mane 1000 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280719833
Net contents 60 Organic Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 325977
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fermented Organic Lion's Mane 1000 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
076280719833
IngredientAmount% DV
Lion's Mane Mushroom, Fermented1000 mg--

Other ingredients: Pullulan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A Brighter Way 1973

Formulation

+ Cognitive support

Vegan

Discussion: Solaray Fermented Lion's Mane is 100% Vegan.

Certified Organic by Utah Department of Agriculture and Food

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

USDA Organic Lab Verified Vegan

General Statements

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR bottles

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Directions: Use only as directed.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 2 capsules daily with a meal or glass of water.

Storage

Store in a cool, dry place. refrigerate after opening.

Formula

Discussion: Solaray Fermented Lion's Mane is 100% Vegan. The organic mushroom mycelium biomass is cultured on organic gluten-free whole oats and then fermented. A mycelium is the vegetative portion of a fungus. It is through this root-like substance that the fungus absorbs nutrients.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fermented Organic Lion's Mane 1000 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fermented Organic Lion's Mane 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fermented Organic Lion's Mane 1000 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Mushroom, Fermented

Interacts with
327 drugs
1000 mg per serving Form: Hericium erinaceus, Fermented, Hericium erinaceus, Fermented

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Mushroom, Fermented monograph & interactions

Other (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fermented Organic Lion's Mane 1000 mg by Solaray Drug Interactions

Want to check YOUR meds against Fermented Organic Lion's Mane 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Mushroom, Fermented 327

Individual Drug Interactions

The ingredients in Fermented Organic Lion's Mane 1000 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Fermented Organic Lion's Mane 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Mushroom, Fermented

Each ingredient & the kinds of drugs it affects

For each ingredient in Fermented Organic Lion's Mane 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Mushroom, Fermented3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Mushroom, Fermented full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fermented Organic Lion's Mane 1000 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Fermented Organic Lion's Mane 1000 mg by Solaray: Common Questions

Does Fermented Organic Lion's Mane 1000 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Fermented Organic Lion's Mane 1000 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fermented Organic Lion's Mane 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is fermented lion's mane, and why is it fermented?
Lion's mane is a medicinal mushroom used traditionally to support brain health. Fermenting it is meant to improve how well your body absorbs and uses it, though the research backing that specific benefit isn't detailed in our data.
Will this help with memory or focus?
Lion's mane is often marketed for cognitive function and memory, but we don't yet have reliable evidence to say it works for these purposes. The rating is insufficient, meaning the research just isn't solid enough either way.
What side effects might I get?
Most people tolerate it well. The most common side effects reported in trials are gastrointestinal discomfort, nausea, and skin rash. If your stomach is sensitive, start with a smaller dose and see how you feel.
Is it safe to take during pregnancy or while breastfeeding?
The safety data advises against it in both cases—there isn't enough information to know whether it's safe for you or your baby. Talk to your doctor or pharmacist about your specific situation.
What is pullulan, and why is it in the capsule?
Pullulan is an inactive ingredient used as the capsule material—it's what holds the mushroom powder together. It's not the active part of the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fermented Organic Lion's Mane 1000 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fermented Organic Lion's Mane 1000 mg label
Go deeper

The Full Monographs Behind Fermented Organic Lion's Mane 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Fermented Organic Lion's Mane 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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