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Dietary supplement

Fermented Reishi 500 mg Ingredients & Drug Interactions

by Solaray

Fermented Reishi 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fermented Reishi 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fermented Reishi 500 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic fermented Reishi Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fermented Reishi 500 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Fermented Reishi 500 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fermented Reishi 500 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: organic fermented Reishi Mushroom at 500 mg per capsule. Reishi is a medicinal fungus traditionally used in Asian medicine.

The capsule itself is made from vegetable cellulose, a plant-based material.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Reishi Mushroom product and its label doesn't state a use — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on reishi for the conditions tested is limited. For high cholesterol (hyperlipidemia), reishi appears possibly ineffective.

For altitude sickness, Alzheimer disease, and athletic performance, we don't have enough reliable evidence yet to say whether it works or doesn't. If you're considering reishi for one of these uses, talk with your doctor or pharmacist about what the current research actually supports for your situation.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom is generally well tolerated in the short term, but long-term safety hasn't been well studied, so we don't know what happens with years of use. The most common side effects are dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Rarely, some people report insomnia or headache. Respiratory allergy to reishi spores can occur — if you develop sore throat, runny nose, or breathing trouble, stop and contact your doctor.

The safety data advises against using reishi during pregnancy and while breastfeeding because there isn't enough information to know it's safe. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood pressure medications (antihypertensive drugs), blood thinners or clot-prevention drugs (anticoagulants or antiplatelet agents), or diabetes medications (antidiabetes drugs) — all three carry moderate-severity interaction risk with reishi.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Reishi is generally well tolerated short-term, but it's not the right fit if you take blood pressure medications, blood thinners, or diabetes drugs without clearing it first with your doctor or pharmacist. The long-term safety picture is thin, and evidence for most uses is limited or absent.

If you're thinking about starting it, check your medications and have that conversation with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fermented Reishi 500 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280598407
Net contents 60 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71557
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fermented Reishi 500 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Cap(s)
Maximum serving Sizes:
2 Veg Cap(s)
Servings per container
30
UPC/BARCODE
076280598407
IngredientAmount% DV
organic fermented Reishi Mushroom1000 mg--

Other ingredients: Vegetable Cellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Organically grown

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Formula

Ganoderma lucidum 500 mg per capsule Mushroom

Seals/Symbols

Lab verified

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take two VegCaps daily with a meal or glass of water.

Storage

Store in a cool, dry place.

General Statements

The organic mushroom mycelium biomass is cultured on organic gluten-free whole oats and then fermented. A mycelium is the vegetative portion of a fungus. It is through this root-like substance that the fungus absorbs nutrients.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

7506376 0716

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fermented Reishi 500 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fermented Reishi 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fermented Reishi 500 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Organic fermented Reishi Mushroom

Interacts with
375 drugs
1000 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Organic fermented Reishi Mushroom monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fermented Reishi 500 mg by Solaray Drug Interactions

Want to check YOUR meds against Fermented Reishi 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

organic fermented Reishi Mushroom 375

Individual Drug Interactions

The ingredients in Fermented Reishi 500 mg interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in Fermented Reishi 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic fermented Reishi Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Fermented Reishi 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic fermented Reishi Mushroom3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
organic fermented Reishi Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fermented Reishi 500 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutrafamily.com
Pharmacist Counseling Corner

Fermented Reishi 500 mg by Solaray: Common Questions

Does Fermented Reishi 500 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Fermented Reishi 500 mg has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fermented Reishi 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with my cholesterol?
No — the data we have suggests reishi is possibly ineffective for high cholesterol. If you're looking for a supplement to manage lipid levels, talk with your doctor about what's been shown to help.
Can I take this while I'm pregnant?
The safety data advises against it. There isn't enough information to know whether reishi is safe during pregnancy. Talk with your doctor or pharmacist before taking it if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
The safety data advises against it. There isn't enough information to know whether reishi passes into breast milk or whether it's safe for a nursing infant. Talk with your doctor or pharmacist if you're breastfeeding.
What are the most common side effects?
Dizziness, dry mouth, itching, nausea, rash, and stomach upset are the most common. Rarely, people report insomnia or headache. If you develop a sore throat, runny nose, or breathing trouble — signs of an allergic reaction to the spores — stop and contact your doctor.
Is this safe to take long-term?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied, so we don't know what risks might come with months or years of regular use. Ask your doctor or pharmacist about the right duration for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fermented Reishi 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fermented Reishi 500 mg label
Go deeper

The Full Monographs Behind Fermented Reishi 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Fermented Reishi 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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