Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Five-Flower Formula Flower Essence Spray Ingredients & Drug Interactions

by Flower Essence Services

Five-Flower Formula Flower Essence Spray label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Five-Flower Formula Flower Essence Spray against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Five-Flower Formula Flower Essence Spray is a dietary supplement by Flower Essence Services with 5 active ingredients. Its ingredients are commonly taken for skin and joint complaints (traditional/folk use), homeopathic remedy for skin conditions, traditional 'counter-irritant' poultice.Based on those ingredients, 156 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Star of Bethlehem. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Five-Flower Formula Flower Essence Spray by Flower Essence Services

Ask about any prescription or over-the-counter medication and we check it for interactions with Five-Flower Formula Flower Essence Spray by Flower Essence Services — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Five-Flower Formula Flower Essence Spray by Flower Essence Services

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Essence Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This formula contains five active flower essences. Clematis vitalba (traveler's joy), Impatiens glandulifera, Rock Rose, Cherry Plum, and Star of Bethlehem make up the blend, along with water and alcohol as inactive ingredients.

Flower essences are highly dilute extracts — this product is a spray meant to be taken by mouth, drop by drop.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: stress relief.
  • We looked for evidence on: anxiety, emotional distress, panic.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness ratings for any of the ingredients in this product. The evidence supporting flower essences for any health purpose is not established in the data we have on file.

The evidence, ingredient by ingredient Traveler's Joy Rock Rose Star Of Bethlehem

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several of these plants carry real safety cautions. Clematis vitalba (the fresh plant) is irritating and potentially toxic if eaten and can cause severe stomach upset, diarrhea, and urinary tract irritation if ingested.

Topically, it can blister and burn skin. Star of Bethlehem contains cardiac glycosides — compounds that affect the heart — and can cause dangerous heart rhythm problems, headache, and vision changes.

Rock Rose has limited human safety data. Because these ingredients are in flower essence form (heavily dilute), the risk is lower than with the raw plant, but the product still carries cautions in pregnancy and breastfeeding.

Clematis vitalba is rated likely unsafe during both; Star of Bethlehem is also rated likely unsafe; Rock Rose is not recommended because safety data are too sparse to know.

Side effects, ingredient by ingredient Traveler's Joy Rock Rose Star Of Bethlehem

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Star Of Bethlehem.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 156 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you use digoxin (a heart drug), diuretics (water pills), corticosteroids, stimulant laxatives, macrolide antibiotics like azithromycin, tetracycline antibiotics, or quinine. All of these have Moderate interactions documented with star of Bethlehem in this product.

Use the medication checker below to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a flower essence product with no established effectiveness in our data. If you take heart medication, water pills, steroids, certain antibiotics, or other drugs on the interaction list, talk to your pharmacist before using it.

It's not recommended in pregnancy or while breastfeeding. Run your exact medications through the checker on this page first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Five-Flower Formula Flower Essence Spray, straight from the product label.

Brand Flower Essence Services
Barcode (UPC) 782932210404
Net contents 1 Fluid Ounce(s); 30 Milliliter(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 296841
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Five-Flower Formula Flower Essence Spray by Flower Essence Services, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Spray(s)
Maximum serving Sizes:
1 Spray(s)
UPC/BARCODE
782932210404
IngredientAmount% DV
Clematis vitalba0 NP--
Impatiens glandulifera0 NP--
Rock Rose0 NP--
Proprietary Essence Blend0 NP--
Cherry Plum0 NP--
Star of Bethlehem0 NP--

Other ingredients: Water, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Dr. Edward Bach's famous formula for stress

Certified Organic by Oregon Tilth Oregon Tilth Certified Organic (OTCO)

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Spray in mouth, repeat as needed.

Formula

Healing herbs

Seals/Symbols

Oregon Tilth Certified Organic (OTCO)

General Statements

Supplement facts: 800-548-0075

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Five-Flower Formula Flower Essence Spray by Flower Essence Services label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Five-Flower Formula Flower Essence Spray label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Five-Flower Formula Flower Essence Spray by Flower Essence Services

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Spray(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Essence Blend

0 NP per serving

Other (inactive) ingredients: Water, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Five-Flower Formula Flower Essence Spray by Flower Essence Services Drug Interactions

Want to check YOUR meds against Five-Flower Formula Flower Essence Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
156Drugs
156 Moderate

Ingredients driving the most interactions

Star of Bethlehem 156

Individual Drug Interactions

The ingredients in Five-Flower Formula Flower Essence Spray interact with 156 drugs. Click any drug to see the details.

1 of the 5 ingredients in Five-Flower Formula Flower Essence Spray interact with drugs. Each result below shows which ingredient is responsible. Star of Bethlehem

Each ingredient & the kinds of drugs it affects

For each ingredient in Five-Flower Formula Flower Essence Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Star of Bethlehem7 drug types · 156 drugs

Corticosteroids

Theoretically, taking star of Bethlehem with prolonged corticosteroid therapy might increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides. Concomitant use of corticosteroids with star of Bethlehem can increase the therapeutic and adverse effects of long-term corticosteroid use due to potassium depletion and electrolyte imbalance.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking star of Bethlehem in combination with digoxin might have additive effects and increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides with effects similar to digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides. Theoretically, concomitant use of potassium-depleting diuretics and star of Bethlehem can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Likelihood Possible Evidence D
Macrolide Antibiotics

Theoretically, taking macrolide antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides. Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.

Likelihood Possible Evidence D
Quinine

Theoretically, taking quinine with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides. Quinine may reduce the clearance of oral digoxin. Theoretically, concomitant use of quinine might reduce the clearance of cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, excessive use of stimulant laxatives with star of Bethlehem might increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides. Excessive use of stimulant laxatives can cause diarrhea, resulting in potassium depletion. This might increase the risk of cardiac glycoside toxicity.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides similar to digitalis. Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.

Likelihood Possible Evidence D
Star of Bethlehem full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Five-Flower Formula Flower Essence Spray, from the product label.

Flower Essence Services

See all Flower Essence Services products
Name
Flower Essence Services
City
Nevada City
State
CA
ZipCode
95959
Phone Number
800-548-0075
Pharmacist Counseling Corner

Five-Flower Formula Flower Essence Spray by Flower Essence Services: Common Questions

Does Five-Flower Formula Flower Essence Spray by Flower Essence Services interact with any medications?
Yes. Based on its ingredients, Five-Flower Formula Flower Essence Spray has a known interaction with 156 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Five-Flower Formula Flower Essence Spray contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
No — the safety data advise against it. Two of the five ingredients, clematis vitalba and star of Bethlehem, are rated likely unsafe in pregnancy. Rock Rose is not recommended because there isn't enough safety information. Talk to your doctor or pharmacist for personalized advice.
What does clematis vitalba (traveler's joy) do in this product?
The facts we have describe the safety risks of the fresh plant (irritation, toxicity, blistering) but don't tell us what its intended role is in this formula. In flower essence form, it's very dilute, so the risk is lower than the raw plant — but caution still applies, especially in pregnancy and breastfeeding.
Can I take this with my heart medication?
It depends which heart medication you take. Star of Bethlehem in this product can interact with digoxin and certain other drugs that affect the heart or electrolytes. Check your exact medication with the tool on this page, or ask your pharmacist before you start.
Does this product have any side effects?
The raw plants can cause serious effects — clematis vitalba can irritate the stomach, diarrhea, and burn skin on contact. Star of Bethlehem can cause heart rhythm problems and headache. Because this is a flower essence (very dilute), the risk is lower, but it's not zero, especially if you take medications that lower potassium.
Is this safe while breastfeeding?
No — clematis vitalba and star of Bethlehem are both rated likely unsafe during breastfeeding. Rock Rose lacks enough safety data to recommend it. Talk to your doctor or pharmacist about what's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Five-Flower Formula Flower Essence Spray label
Go deeper

The Full Monographs Behind Five-Flower Formula Flower Essence Spray’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Traveler's Joy

Traveler's Joy (Clematis vitalba) is a wild climbing vine that is best known as an ornamental hedge plant, not as a proven medicine. The fresh plant is irritating and can be toxic if eaten,...

Read the full Traveler's Joy monograph → Herb & supplement monograph

Rock Rose

Rock Rose usually refers to plants in the Cistus family, taken as a tea or extract and traditionally used for colds, sore throats, and as an antimicrobial; it is also a Bach flower remedy us...

Read the full Rock Rose monograph → Herb & supplement monograph

Star Of Bethlehem

Interacts with 156 drugs

Star of Bethlehem is a small flowering plant best known as one of the ingredients in Bach flower remedies, where it is used for emotional shock and grief. There is no solid scientific eviden...

Read the full Star Of Bethlehem monograph →
Sources

Sources & How We Checked

Five-Flower Formula Flower Essence Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Traveler's Joy 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Traveler's Joy monograph →

Rock Rose 2 references
  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbal and Dietary Supplements — MedlinePlus (U.S. National Library of Medicine) Source

See these in context on the Rock Rose monograph →

Star Of Bethlehem 8 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
  6. Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.
  7. Vogelsang A. Clinical trial of Ornithogalum umbellatum on the human heart; preliminary report. Can Med Assoc J 1955;73:295-6.
  8. Smith JA, Paterson GR. Rhodexin A and rhodexoside in Ornithogalum umbellatum. J Pharm Pharmacol 1967;19:221-5.

See these in context on the Star Of Bethlehem monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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