Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Five-Flower Formula Flower Essence Ingredients & Drug Interactions

by Flower Essence Services

Five-Flower Formula Flower Essence label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Five-Flower Formula Flower Essence against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Five-Flower Formula Flower Essence is a dietary supplement by Flower Essence Services with 5 active ingredients. Its ingredients are commonly taken for skin and joint complaints (traditional/folk use), homeopathic remedy for skin conditions, traditional 'counter-irritant' poultice.Based on those ingredients, 156 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ornithogalum umbellatum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Five-Flower Formula Flower Essence by Flower Essence Services

Ask about any prescription or over-the-counter medication and we check it for interactions with Five-Flower Formula Flower Essence by Flower Essence Services — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Five-Flower Formula Flower Essence by Flower Essence Services

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “infusions (1:6000) of” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This flower essence blend contains five ingredients in highly diluted form (1 to 6,000). The main active components are infusions of clematis vitalba, Prunus cerasifera, Impatiens glandulifera, rock rose (Helianthemum nummularium), and star of Bethlehem (Ornithogalum umbellatum).

The liquid is suspended in water and brandy as inactive carriers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness data for any of the five active ingredients in this formula. That means the evidence supporting their use isn't established in our database.

If you're considering this product for a specific condition, talk with your pharmacist or doctor about what the current research shows.

The evidence, ingredient by ingredient Traveler's Joy Rock Rose Star Of Bethlehem

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Clematis vitalba is the fresh plant that's potentially toxic if eaten and can irritate your stomach badly, causing colic and diarrhea; it can also blister your skin on contact. Star of Bethlehem contains cardiac glycosides — compounds that can seriously affect your heart — and while commercial flower essences are extremely dilute, good safety studies are lacking.

Both of these ingredients should be avoided in pregnancy and while breastfeeding. Rock rose is often tolerated well in food amounts, but human safety data are limited and it's best avoided during pregnancy and lactation too.

Side effects, ingredient by ingredient Traveler's Joy Rock Rose Star Of Bethlehem

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Star Of Bethlehem.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 156 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use heart or blood pressure medications, corticosteroids (like prednisone), diuretics (water pills), macrolide or tetracycline antibiotics, digoxin, quinine, or stimulant laxatives. All carry Moderate interaction risk with star of Bethlehem.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product contains ingredients with real toxicity concerns, especially if you take heart medications, certain antibiotics, or diuretics. Clematis vitalba and star of Bethlehem carry the most serious safety flags.

Before you start, check your exact medications with the tool on this page, and talk to your pharmacist — especially if you're pregnant, breastfeeding, or have heart conditions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Five-Flower Formula Flower Essence, straight from the product label.

Brand Flower Essence Services
Barcode (UPC) 782932220397
Net contents 0.25 fl. Oz.; 7.5 mL
Market status On market
Date entered into DSLD Jan 24, 2014
DSLD ID 29854
Product type Botanical
Supplement form Liquid
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Five-Flower Formula Flower Essence by Flower Essence Services, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0 Not Present
Maximum serving Sizes:
0 Not Present
UPC/BARCODE
782932220397
IngredientAmount% DV
infusions (1:6000) of0 NP--
Clematis vitalba0 NP--
Prunus cerasifera0 NP--
Impatiens glandulifera0 NP--
Helianthemum nummularium0 NP--
Ornithogalum umbellatum0 NP--

Other ingredients: Water, brandy

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

herbal supplement

Seals/Symbols

Healingherbs(R)

DEMETER(R)

Brand IP Statement(s)

Demeter-certified Biodynamic(R)

General Statements

BEST BY 03/2022 120307

Formulation

Certified organic by Stellar Certification Services, Inc.

General

120307

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Five-Flower Formula Flower Essence by Flower Essence Services label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Five-Flower Formula Flower Essence label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Five-Flower Formula Flower Essence by Flower Essence Services

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size0 Not Present Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Infusions (1:6000) of

0 NP per serving

Other (inactive) ingredients: Water, Brandy. These complete the product’s ingredient list but are not active constituents.

Interaction report

Five-Flower Formula Flower Essence by Flower Essence Services Drug Interactions

Want to check YOUR meds against Five-Flower Formula Flower Essence?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
156Drugs
156 Moderate

Ingredients driving the most interactions

Ornithogalum umbellatum 156

Individual Drug Interactions

The ingredients in Five-Flower Formula Flower Essence interact with 156 drugs. Click any drug to see the details.

1 of the 5 ingredients in Five-Flower Formula Flower Essence interact with drugs. Each result below shows which ingredient is responsible. Ornithogalum umbellatum

Each ingredient & the kinds of drugs it affects

For each ingredient in Five-Flower Formula Flower Essence with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ornithogalum umbellatum7 drug types · 156 drugs

Corticosteroids

Theoretically, taking star of Bethlehem with prolonged corticosteroid therapy might increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides. Concomitant use of corticosteroids with star of Bethlehem can increase the therapeutic and adverse effects of long-term corticosteroid use due to potassium depletion and electrolyte imbalance.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking star of Bethlehem in combination with digoxin might have additive effects and increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides with effects similar to digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking diuretics with star of Bethlehem might increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides. Theoretically, concomitant use of potassium-depleting diuretics and star of Bethlehem can increase the risk of cardiac glycoside toxicity due to potassium depletion.

Likelihood Possible Evidence D
Macrolide Antibiotics

Theoretically, taking macrolide antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides. Macrolide antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of macrolide antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.

Likelihood Possible Evidence D
Quinine

Theoretically, taking quinine with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides. Quinine may reduce the clearance of oral digoxin. Theoretically, concomitant use of quinine might reduce the clearance of cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, excessive use of stimulant laxatives with star of Bethlehem might increase the risk of toxicity.
Star of Bethlehem contains cardiac glycosides. Excessive use of stimulant laxatives can cause diarrhea, resulting in potassium depletion. This might increase the risk of cardiac glycoside toxicity.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with star of Bethlehem might increase the risk of cardiac glycoside toxicity.
Star of Bethlehem contains cardiac glycosides similar to digitalis. Tetracycline antibiotics appear to increase the gastrointestinal absorption of oral digoxin. Theoretically, concomitant use of tetracycline antibiotics might increase the absorption of the cardiac glycosides found in star of Bethlehem and increase the risk of adverse effects.

Likelihood Possible Evidence D
Ornithogalum umbellatum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Five-Flower Formula Flower Essence, from the product label.

Flower Essence Services

See all Flower Essence Services products
Phone Number
800-548-0075
Pharmacist Counseling Corner

Five-Flower Formula Flower Essence by Flower Essence Services: Common Questions

Does Five-Flower Formula Flower Essence by Flower Essence Services interact with any medications?
Yes. Based on its ingredients, Five-Flower Formula Flower Essence has a known interaction with 156 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Five-Flower Formula Flower Essence contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The product contains clematis vitalba and star of Bethlehem, both rated likely unsafe in pregnancy and lactation because of potential toxicity and missing safety data. Rock rose also lacks enough safety information for pregnancy and breastfeeding. Talk with your doctor or pharmacist before using it in either situation.
What does clematis vitalba do in this formula?
We don't have effectiveness data for clematis vitalba in our database. What we do know is that the fresh plant is irritating and potentially toxic if eaten, can cause severe stomach upset and diarrhea, and can blister your skin.
Is this safe to take with digoxin or other heart medications?
No — star of Bethlehem in this formula contains cardiac glycosides that can work together with digoxin and corticosteroids to raise toxicity risk. Check your exact medications with the tool on this page and talk to your pharmacist.
What side effects can happen from star of Bethlehem?
Star of Bethlehem contains toxic compounds that can cause cardiac arrhythmias (irregular heartbeats), headache, confusion, and visual disturbances. Serious effects like arrhythmia and even death are rare but possible if taken in significant amounts.
Why does the label say 1:6000 dilution?
The flower essences are highly diluted — one part plant material to 6,000 parts liquid. While this extreme dilution is standard for flower essences, the safety data on these specific ingredients is still limited.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Five-Flower Formula Flower Essence is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Five-Flower Formula Flower Essence label
Go deeper

The Full Monographs Behind Five-Flower Formula Flower Essence’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Traveler's Joy

Traveler's Joy (Clematis vitalba) is a wild climbing vine that is best known as an ornamental hedge plant, not as a proven medicine. The fresh plant is irritating and can be toxic if eaten,...

Read the full Traveler's Joy monograph → Herb & supplement monograph

Rock Rose

Rock Rose usually refers to plants in the Cistus family, taken as a tea or extract and traditionally used for colds, sore throats, and as an antimicrobial; it is also a Bach flower remedy us...

Read the full Rock Rose monograph → Herb & supplement monograph

Star Of Bethlehem

Interacts with 156 drugs

Star of Bethlehem is a small flowering plant best known as one of the ingredients in Bach flower remedies, where it is used for emotional shock and grief. There is no solid scientific eviden...

Read the full Star Of Bethlehem monograph →
Sources

Sources & How We Checked

Five-Flower Formula Flower Essence's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Traveler's Joy 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Traveler's Joy monograph →

Rock Rose 2 references
  1. Herbs at a Glance — NIH National Center for Complementary and Integrative Health (NCCIH) Source
  2. Herbal and Dietary Supplements — MedlinePlus (U.S. National Library of Medicine) Source

See these in context on the Rock Rose monograph →

Star Of Bethlehem 8 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  5. Waud RA. The action of Ornithogalum umbellatum on the heart. J Pharmacol Exp Ther 1954;111:147-51. DOI
  6. Vogelsang A. Ornithogalum umbellatum in the treatment of congestive heart failure: progress report. J Am Geriatr Soc 1961;9:1096-9.
  7. Vogelsang A. Clinical trial of Ornithogalum umbellatum on the human heart; preliminary report. Can Med Assoc J 1955;73:295-6.
  8. Smith JA, Paterson GR. Rhodexin A and rhodexoside in Ornithogalum umbellatum. J Pharm Pharmacol 1967;19:221-5.

See these in context on the Star Of Bethlehem monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team