Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Flax Seed Oil Ingredients & Drug Interactions

by Higher Nature

Flax Seed Oil label
See full label image
Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flax Seed Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flax Seed Oil is a dietary supplement by Higher Nature with 3 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flax Seed Oil by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with Flax Seed Oil by Higher Nature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Flax Seed Oil by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 3 active ingredients: oleic acid, linoleic acid, and alpha-linolenic acid. Together, these are the fatty acids that make up flax seed oil — the cold-pressed, unrefined seed oil itself is delivered in a capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Plant source omega 3 for health.
  • We looked for evidence on: Coronary heart disease (CHD), Hypercholesterolemia, Hypertension, Stroke, Cardiovascular health, Inflammation.
  • The strongest evidence on file: Oleic Acid is rated "Possibly Effective" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Oleic Acid is rated "Possibly Effective" for Hypercholesterolemia.
  • Also on file: Oleic Acid is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Stroke.

Oleic acid is possibly effective for high cholesterol and heart disease prevention. The evidence comes from diet studies and isn't the same as taking a supplement, so results may vary depending on how much you take and your individual situation.

The evidence, ingredient by ingredient Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid from food sources like olive oil is generally well tolerated. Concentrated supplement doses in pregnancy and breastfeeding haven't been well studied, so there isn't enough data to know whether they're safe at higher levels.

Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications if you take antidiabetes drugs (including insulin and oral medications). Oleic acid may increase their blood-sugar-lowering effect.

We couldn't check linoleic acid or alpha-linolenic acid, so ask your pharmacist about those as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

This flax seed oil product may help with cholesterol and heart health, but it could strengthen the effect of diabetes medications. If you take any diabetes drug, check with your doctor or pharmacist before starting.

If you're pregnant or breastfeeding, there isn't enough safety data for supplement doses — ask your healthcare provider whether it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flax Seed Oil, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013104985
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 245671
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flax Seed Oil by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
180
UPC/BARCODE
5031013104985
IngredientAmount% DV
Linoleic Acid309 mg--
Oleic Acid309 mg--
Alpha-Linolenic Acid987 mg--

Other ingredients: cold-pressed, unrefined Flax (Linum usitatissimum) seed oil, Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free From: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, soya, starch, sugar, wheat, yeast.

Advanced formula Optimal benefit

General Statements

This product has not been tested on animals.

Everyday Essentials

Formula

Plant source omega 3

High in plant source omega 3 Cold pressed flax seed oil providing 50-55% omega 3 With omegas 6 and 9

FDA Statement of Identity

Food Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1-3 capsules 3 times a day.

Precautions

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Storage: Store in a cool, dry place out of reach of children.

Storage

Storage: Store in a cool, dry place out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flax Seed Oil by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flax Seed Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flax Seed Oil by Higher Nature

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Linoleic Acid

309 mg per serving

Oleic Acid

Interacts with
86 drugs
309 mg per serving

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it...

Oleic Acid monograph & interactions

Alpha-Linolenic Acid

987 mg per serving

Other (inactive) ingredients: Cold-pressed, unrefined Flax (Linum usitatissimum) seed oil, Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flax Seed Oil by Higher Nature Drug Interactions

Want to check YOUR meds against Flax Seed Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Oleic Acid 86

Individual Drug Interactions

The ingredients in Flax Seed Oil interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Flax Seed Oil interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Flax Seed Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flax Seed Oil, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature Ltd
Street Address
10 Discovery Way
City
Horam, East Sussex
ZipCode
TN21 0GE
Web Address
highernature.com
Pharmacist Counseling Corner

Flax Seed Oil by Higher Nature: Common Questions

Does Flax Seed Oil by Higher Nature interact with any medications?
Yes. Based on its ingredients, Flax Seed Oil has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flax Seed Oil contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this flax seed oil lower my blood sugar if I take diabetes medication?
Oleic acid in this product may increase how well your diabetes medication works, which could lower your blood sugar more than usual. That's why it's important to check with your doctor or pharmacist before taking it alongside any diabetes drug — they may need to monitor your levels or adjust your dose.
Is flax seed oil safe to take during pregnancy?
Food amounts of oleic acid are fine, but concentrated supplement doses haven't been well studied in pregnancy. There isn't enough data to know whether supplement-level doses are safe. Talk with your doctor or pharmacist about your individual situation before taking this product.
Is flax seed oil safe while breastfeeding?
Food amounts of oleic acid are considered safe, but concentrated supplement doses lack good safety data during lactation. Ask your doctor or pharmacist whether this product is right for you while breastfeeding.
What is oleic acid and why is it in this product?
Oleic acid is one of the main fatty acids naturally found in flax seed oil. It's the component that research suggests may help with cholesterol and heart health.
Does this flax seed oil actually work for cholesterol?
The oleic acid in flax seed oil is possibly effective for high cholesterol and heart disease, based on research. Results depend on how much you take and how your body responds, so individual outcomes vary.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flax Seed Oil is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flax Seed Oil label
Go deeper

The Full Monographs Behind Flax Seed Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Flax Seed Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 1 reference
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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