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Dietary supplement

Forskohlii 385 mg Ingredients & Drug Interactions

by Solaray

Forskohlii 385 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Forskohlii 385 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Forskohlii 385 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for weight management, asthma and breathing, high blood pressure.Based on those ingredients, 915 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Forskohlii Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Forskohlii 385 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Forskohlii 385 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Forskohlii 385 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Forskohlii Root Extract” is listed as a grouped ingredient — the label gives one combined amount (385 mg) without saying how much of each component you get.

This product contains one active ingredient: forskolin (385 mg per capsule), a compound extracted from Coleus forskohlii root. Forskolin is thought to work in the body by triggering a chain of cellular effects, though the evidence for its effectiveness in treating specific conditions is not yet established in our data.

The capsule also contains inactive ingredients—cellulose, rice flour, rice bran extract, and silica—which are fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Coleus product and its label doesn't state a use — see Coleus's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold does not establish that forskohlii is effective for any of the conditions listed on the label, including angina, asthma, cancer, congestive heart failure, eczema, or dry eye. All six of these conditions show insufficient reliable evidence to rate.

If you're considering this product for a specific health concern, talk with your doctor or pharmacist about what the research actually shows and whether it's right for your situation.

The evidence, ingredient by ingredient Coleus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oral coleus is generally well tolerated, but it does carry some risks. The most common side effects are gastrointestinal: diarrhea, constipation, nausea, and vomiting.

One clinical trial reported loose stools in 1 out of 15 patients, and other data suggests about a 10% rate of digestive upset overall, mostly diarrhea. Forskolin can also lower blood pressure, so use with caution and professional guidance, especially long-term.

The safety data advises against use during pregnancy and breastfeeding because not enough is known about potential risks to the baby. If you are pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Coleus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 916 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Solaray Forskohlii, double-check these medication types with your pharmacist or on the interaction tool below: nitrates and calcium channel blockers (heart/chest pain medications—these are Major interactions), antihypertensive drugs (blood pressure medications), blood thinners and antiplatelet drugs (like warfarin or aspirin), and any drugs your liver breaks down via CYP2C9 or CYP3A4 enzymes (a very large group including many common medications).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Forskohlii may be worth considering if you've discussed it with your pharmacist and ruled out interactions with your medications. If you take any heart medications, blood pressure drugs, blood thinners, or medications broken down by your liver, you need to check this product against your exact prescription list first.

Digestive upset is common, and the evidence for its claimed uses is not yet solid. Your pharmacist can help you decide whether it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Forskohlii 385 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280399080
Net contents 60 VegCap(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 339089
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Forskohlii 385 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
60
UPC/BARCODE
076280399080
IngredientAmount% DV
Forskolin3.85 mg--
Forskohlii Root Extract385 mg--

Other ingredients: Cellulose, Rice Flour, Rice Bran Extract, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A Brighter Way 1973

General Statements

Vital Extracts

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR bottles

Formula

1% Forskolin

Discussion: Forskohlii (Coleus forskohlii), a member of the mint family, grows on the sun-exposed, dry slopes of India. It is used in traditional Ayurvedic practices. Forskolin is a diterpene compound found in Coleus forskohlii. Forskolin has been the subject of several research studies since 1981. This product is guaranteed to contain 1% forskolin.

Formulation

Herbal Support

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified

Precautions

Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.

Keep out of reach of children.

Directions: Use only as directed.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 1 VegCap daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Forskohlii 385 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Forskohlii 385 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Forskohlii 385 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Forskohlii Root Extract

Interacts with
915 drugs
385 mg per serving Form: Coleus forskohlii Root Extract

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Forskohlii Root Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Rice Flour, Rice Bran Extract, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Forskohlii 385 mg by Solaray Drug Interactions

Want to check YOUR meds against Forskohlii 385 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
915Drugs
29 Major 886 Moderate

Ingredients driving the most interactions

Forskohlii Root Extract 915

Individual Drug Interactions

The ingredients in Forskohlii 385 mg interact with 915 drugs. Click any drug to see the details.

1 of the 1 ingredient in Forskohlii 385 mg interact with drugs. Each result below shows which ingredient is responsible. Forskohlii Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Forskohlii 385 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Forskohlii Root Extract7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Forskohlii Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Forskohlii 385 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

Forskohlii 385 mg by Solaray: Common Questions

Does Forskohlii 385 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Forskohlii 385 mg has a known interaction with 915 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Forskohlii 385 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects if I take this?
The most common side effects are digestive: diarrhea, constipation, nausea, and vomiting. Diarrhea and loose stools appear most often. One clinical trial saw loose stools in 1 out of 15 people taking the extract, and other data suggests roughly a 10% rate of digestive upset overall.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy, and there isn't enough data to know whether it's safe while breastfeeding. Talk with your doctor or pharmacist before considering this product if you're pregnant, planning to become pregnant, or nursing.
Does forskohlii actually work for the conditions on the label?
The evidence we hold shows insufficient reliable data to establish that it works for angina, asthma, cancer, congestive heart failure, eczema, or dry eye. If you're considering it for one of these conditions, ask your doctor or pharmacist what the research really supports.
Can this lower my blood pressure?
Yes, animal research shows that forskolin, the active ingredient, may lower blood pressure. If you already take blood pressure medications or have low blood pressure, use this product only under professional guidance and have your blood pressure monitored.
Is this safe to use long-term?
Coleus is generally well tolerated when taken by mouth, but it's not well studied for long-term use. Use with care and talk with your pharmacist or doctor before taking it over an extended period.
What exactly is in this capsule besides the active ingredient?
The capsule contains cellulose, rice flour, rice bran extract, and silica—these are inactive ingredients that serve as fillers and binders to hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Forskohlii 385 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Forskohlii 385 mg label
Go deeper

The Full Monographs Behind Forskohlii 385 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph →
Sources

Sources & How We Checked

Forskohlii 385 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coleus 16 references
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
  3. Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed
  4. Christenson JT, Thulesius O, Nazzal MM. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995;24:56-61.
  5. Agarwal KC, Zielinski BA, Maitra RS. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Thromb Haemost 1989;61:106-10. DOI
  6. Agarwal KC, Parks RE. Forskolin: a potential antimetastatic agent. Int J Cancer 1983;32:801-4. PubMed
  7. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol 2000;73(1-2):53-60. PubMed
  8. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
  9. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed
  10. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed
  11. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
  12. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
  13. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
  14. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
  15. Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.
  16. Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients. 2019;11(4). pii: E866. PubMed

See these in context on the Coleus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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