Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Forskolin Ingredients & Drug Interactions

by Natures Craft

Forskolin label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Forskolin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Forskolin is a dietary supplement by Natures Craft with 2 active ingredients. Its ingredients are commonly taken for weight management, asthma and breathing, high blood pressure.Based on those ingredients, 917 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Coleus forskohlii Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Forskolin by Natures Craft

Ask about any prescription or over-the-counter medication and we check it for interactions with Forskolin by Natures Craft — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Forskolin by Natures Craft

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.

The active ingredients are Coleus forskohlii root extract and forskolin, a constituent of coleus. The label lists two active ingredients, and both entries are linked to the same coleus monograph in our data.

The label also lists inactive ingredients: cellulose, microcrystalline cellulose, magnesium stearate, and silicon dioxide. These are fillers, binders, and similar non-active materials.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Coleus product and its label doesn't state a use — see Coleus's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Our data does not establish that coleus or forskolin works for any condition. Ratings for angina, asthma, cancer, congestive heart failure, atopic dermatitis (eczema), and dry eye are all listed as insufficient reliable evidence to rate.

In other words, the evidence for these uses isn't established in the data we hold, so no benefit should be assumed.

The evidence, ingredient by ingredient Coleus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coleus is generally well tolerated across the routes studied, though it is not well studied for long-term use. Its safety notes advise caution because it may lower blood pressure, so it should be used with care and professional guidance.

The most common side effects are gastrointestinal, including constipation, diarrhea, nausea, and vomiting. In a clinical trial, loose stools and more frequent bowel movements were reported by a small number of participants.

Inhaled forskolin can irritate the throat and airways and cause cough.

Side effects, ingredient by ingredient Coleus

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 918 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Nitrates and calcium channel blockers carry the most serious documented interaction rating, Major, so check these first. Antihypertensive drugs, anticoagulant and antiplatelet drugs, warfarin, and medicines handled by CYP2C9 and CYP3A4 are rated Moderate.

Confirm any of these with your own doctor or pharmacist before combining them with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may be of interest to adults looking into coleus-based supplements who have no relevant medication conflicts. If you take heart medicines, blood pressure medicines, blood thinners, or warfarin, or you have blood pressure concerns, be careful and talk it over with your own doctor or pharmacist before starting.

Pregnancy and breastfeeding need a personal conversation with your healthcare provider too.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Forskolin, straight from the product label.

Brand Natures Craft
Barcode (UPC) X001QLOZTZ
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321683
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Forskolin by Natures Craft, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
60
UPC/BARCODE
X001QLOZTZ
IngredientAmount% DV
Coleus forskohlii Root Extract0 NP--
Forskolin250 mg--

Other ingredients: Cellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: as a dietary supplement take one (1) capsule (on an empty stomach) with a full glass of water 30-60 minutes before a meal, twice daily.

Precautions

Caution: if you are pregnant, nursing taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any reactions occur. Do not use if safety seal is damaged or missing.

Warning: Keep out of the reach of children.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or mitigate any disease.

General Statements

Nature at its finest

Please recycle.

Formula

Coleus forskohlii with standardized 20%

Formulation

Boosts metabolism Helps increase weight loss Reduces high blood pressure

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP Good Manufacturing Practice Great quality Proudly made in USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Forskolin by Natures Craft label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Forskolin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Forskolin by Natures Craft

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Coleus forskohlii Root Extract

Interacts with
917 drugs
0 NP per serving Form: Forskolin

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Coleus forskohlii Root Extract monograph & interactions

Forskolin

Interacts with
917 drugs
250 mg per serving

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Forskolin monograph & interactions

Other (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Forskolin by Natures Craft Drug Interactions

Want to check YOUR meds against Forskolin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
917Drugs
29 Major 888 Moderate

Ingredients driving the most interactions

Coleus forskohlii Root Extract 917

Individual Drug Interactions

The ingredients in Forskolin interact with 917 drugs. Click any drug to see the details.

1 of the 2 ingredients in Forskolin interact with drugs. Each result below shows which ingredient is responsible. Coleus forskohlii Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Forskolin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coleus forskohlii Root Extract7 drug types · 917 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Coleus forskohlii Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Forskolin, from the product label.

Natures Craft

See all Natures Craft products
Name
Nature's Design
City
Monsey
State
NY
ZipCode
10952
Phone Number
408-599-3841
Web Address
shopnaturesdesign.com
Pharmacist Counseling Corner

Forskolin by Natures Craft: Common Questions

Does Forskolin by Natures Craft interact with any medications?
Yes. Based on its ingredients, Forskolin has a known interaction with 917 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Forskolin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Forskolin safe to take during pregnancy?
Our pregnancy rating for coleus is possibly unsafe, and the safety data advises against using it during pregnancy. Please talk with your own doctor or pharmacist about your situation.
Does forskolin help with eczema or dry eye?
The evidence isn't established in the data we hold. Both eczema (atopic dermatitis) and dry eye are rated insufficient reliable evidence to rate.
What side effects can coleus cause?
The most common are digestive effects such as constipation, diarrhea, nausea, and vomiting. Inhaled forskolin can irritate the throat and airways.
Can forskolin lower blood pressure?
Animal research suggests forskolin may lower blood pressure, and the safety notes advise caution for this reason. Talk with your own doctor about blood pressure before starting.
Is Forskolin safe while breastfeeding?
Our safety notes advise avoiding it while breastfeeding, but the formal lactation rating for this product is blank in our data. Please discuss breastfeeding with your own doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Forskolin label
Go deeper

The Full Monographs Behind Forskolin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coleus

Interacts with 917 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph →
Sources

Sources & How We Checked

Forskolin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coleus 16 references
  1. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
  2. Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
  3. Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed
  4. Christenson JT, Thulesius O, Nazzal MM. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995;24:56-61.
  5. Agarwal KC, Zielinski BA, Maitra RS. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Thromb Haemost 1989;61:106-10. DOI
  6. Agarwal KC, Parks RE. Forskolin: a potential antimetastatic agent. Int J Cancer 1983;32:801-4. PubMed
  7. Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol 2000;73(1-2):53-60. PubMed
  8. Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
  9. Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed
  10. van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed
  11. Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
  12. Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
  13. Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
  14. Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
  15. Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.
  16. Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients. 2019;11(4). pii: E866. PubMed

See these in context on the Coleus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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