French Maritime Pine Bark Extract 400 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking French Maritime Pine Bark Extract 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
French Maritime Pine Bark Extract 400 mg is a dietary supplement by Signature Supplements with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are French Maritime Pine Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against French Maritime Pine Bark Extract 400 mg by Signature Supplements
Ask about any prescription or over-the-counter medication and we check it for interactions with French Maritime Pine Bark Extract 400 mg by Signature Supplements — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of French Maritime Pine Bark Extract 400 mg by Signature Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: French Maritime Pine Bark Extract, 400 mg per capsule. The extract also includes two inactive ingredients — cellulose and diatomaceous earth — which help form and stabilize the capsule.
Does it work?
Moderate evidence
French Maritime Pine Bark Extract is possibly effective for osteoarthritis and chronic venous insufficiency (a condition where veins struggle to pump blood back to the heart, causing leg swelling and discomfort). The evidence for other uses is less established.
For high cholesterol (hyperlipidemia), the data we hold rates it as possibly ineffective, and for asthma it's possibly effective — but the strength of evidence varies.
How safe is it?
Well-documented data
Maritime pine bark extract is generally well tolerated in studies, though long-term safety data is limited. The most common side effects are gastrointestinal upset, dizziness, and vertigo.
Headache and a single report of chest pain have been noted in trials, though it's unclear whether these were directly caused by the extract. Because there isn't enough safety data, it's best avoided during pregnancy and while breastfeeding — talk with your pharmacist or doctor if you're in either situation and considering this supplement.
Meds to double-check
Moderate interaction found
Check with your pharmacist before using this if you take blood thinners or antiplatelet drugs (like warfarin or aspirin), diabetes medications, or immunosuppressants. These are documented Moderate interactions — your pharmacist can review your specific drugs and may suggest monitoring or dose adjustments.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
French Maritime Pine Bark Extract may be worth trying if you have osteoarthritis or chronic venous insufficiency and your doctor approves. If you take blood thinners, diabetes medications, or immunosuppressants, you must check with your pharmacist first — this extract could affect how they work.
Dizziness and stomach upset are possible, so start low and see how you respond.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about French Maritime Pine Bark Extract 400 mg, straight from the product label.
| Brand | Signature Supplements |
|---|---|
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 338925 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for French Maritime Pine Bark Extract 400 mg by Signature Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| French Maritime Pine Bark Extract | 400 mg | -- |
Other ingredients: Cellulose, Diatomaceous Earth
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Contains no: Chemical Fillers or Binders, Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.
We have assayed & fully guarantee the quality & potency of this product From a GMP Facility
FDA Statement of Identity
Dietary Supplement
Formula
Potent Antioxidant
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) capsule daily, preferably with meals.
Precautions
As a reminder, discuss the supplements and medications you take with your health care providers.
Keep out of reach of children.
Storage
Store in a dry place and avoid excessive heat.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
French Maritime Pine Bark Extract 400 mg by Signature Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in French Maritime Pine Bark Extract 400 mg by Signature Supplements
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
French Maritime Pine Bark Extract
Interacts with327 drugs
Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...
French Maritime Pine Bark Extract monograph & interactionsOther (inactive) ingredients: Cellulose, Diatomaceous Earth. These complete the product’s ingredient list but are not active constituents.
French Maritime Pine Bark Extract 400 mg by Signature Supplements Drug Interactions
HelloPharmacist Interaction Report
French Maritime Pine Bark Extract by Signature Supplements has Moderate interactions documented with three categories of medications.
The most serious concern is with blood thinners and antiplatelet drugs (anticoagulants/antiplatelets). Maritime pine bark extract can theoretically increase bleeding risk because it may slow blood clotting.
The clinical significance isn't entirely clear, but if you take warfarin, aspirin, clopidogrel, or similar agents, this is worth checking.
Read the full breakdown — every affected drug type, severity by severity
It also interacts Moderately with diabetes medications and immunosuppressants. For diabetes drugs, maritime pine bark extract might lower your blood sugar further — one study showed this effect in patients already on diabetes treatment.
For immunosuppressants (used after organ transplant or for certain autoimmune conditions), the extract's immune-stimulating activity could theoretically reduce how well these drugs work, though this hasn't been seen in humans yet.
Before you start, check your exact medications with the search tool on this page. Altogether, these interactions span 322 individual medications.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against French Maritime Pine Bark Extract 400 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in French Maritime Pine Bark Extract 400 mg interact with 327 drugs. Click any drug to see the details.
1 of the 1 ingredient in French Maritime Pine Bark Extract 400 mg interact with drugs. Each result below shows which ingredient is responsible. French Maritime Pine Bark Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with French Maritime Pine Bark Extract 400 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Anisindione interactionEach ingredient & the kinds of drugs it affects
For each ingredient in French Maritime Pine Bark Extract 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
French Maritime Pine Bark Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for French Maritime Pine Bark Extract 400 mg, from the product label.
Signature Supplements
See all Signature Supplements products- Name
- Signature Supplements
- Street Address
- P.O. Box 1112
- City
- San Clemente
- State
- CA
- Web Address
- yoursignaturesupplements.com
French Maritime Pine Bark Extract 400 mg by Signature Supplements: Common Questions
Does French Maritime Pine Bark Extract 400 mg by Signature Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is maritime pine bark extract and what is it supposed to do?
Can I take this if I'm pregnant or breastfeeding?
What side effects should I watch for?
How long until it works?
Is this the same as Pycnogenol?
What are the inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if French Maritime Pine Bark Extract 400 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind French Maritime Pine Bark Extract 400 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
French Maritime Pine Bark Extract 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC