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Dietary supplement

Full Spectrum Sarsaparilla Root 450 mg Ingredients & Drug Interactions

by Swanson

Full Spectrum Sarsaparilla Root 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Full Spectrum Sarsaparilla Root 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Full Spectrum Sarsaparilla Root 450 mg is a dietary supplement by Swanson with 1 active ingredient. Its ingredients are commonly taken for skin conditions like psoriasis, joint pain and arthritis, general tonic or 'blood purifier'.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sarsaparilla. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Full Spectrum Sarsaparilla Root 450 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with Full Spectrum Sarsaparilla Root 450 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Full Spectrum Sarsaparilla Root 450 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: sarsaparilla root, 450 mg per capsule. It's a traditional botanical used in herbal medicine, though clinical evidence for its effects remains limited.

The capsule itself is made with gelatin, microcrystalline cellulose (a binder), magnesium stearate (a flow agent), and silica—all inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Sarsaparilla's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: kidney urinary tract and skin health.
  • We looked for evidence on: Psoriasis, urinary tract health, kidney health.
  • The closest evidence on file: Sarsaparilla is rated "Insufficient Reliable Evidence To Rate" for Psoriasis (Natural Medicines).

The evidence we hold on sarsaparilla for cancer, psoriasis, and rheumatoid arthritis (RA)—three conditions people sometimes consider it for—shows insufficient reliable evidence to rate how well it works. That means studies haven't established its benefit for these uses.

If you're thinking about this product for a specific health concern, talk it over with your doctor or pharmacist to understand what the science actually supports.

The evidence, ingredient by ingredient Sarsaparilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sarsaparilla is likely low-risk at food amounts, but human safety data for supplement doses are limited—we don't have robust real-world safety information yet. One occupational concern is that breathing in sarsaparilla root dust can trigger rhinitis and asthma symptoms, though that's not relevant to swallowing capsules.

The safety data advises against use during pregnancy and while breastfeeding due to insufficient information. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Sarsaparilla

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Sarsaparilla.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you're on lithium (for mood disorders) or digoxin/Lanoxin (a heart medication)—both are Moderate-severity interactions involving sarsaparilla's diuretic action. Your doctor or pharmacist can advise whether the timing or dose needs adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Sarsaparilla Root from Swanson is a single-ingredient botanical supplement with two notable medication interactions—both with heart-related or mood-disorder drugs. The effectiveness evidence for common uses is not yet established.

If you take lithium, digoxin, or any other heart medication, check your full medication list with your doctor or pharmacist before starting, because diuretics can affect how these drugs work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Full Spectrum Sarsaparilla Root 450 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614114040
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 308569
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Full Spectrum Sarsaparilla Root 450 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
087614114040
IngredientAmount% DV
Sarsaparilla900 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Traditionally used for kidney, urinary tract and skin health General tonic for overall health Full Spectrum whole root formula

Kidney and urinary tract health

Brand IP Statement(s)

Science-backed quality since 1969

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take two capsules per day with water.

Precautions

Warning: For adults only. Keep out of reach of children.

Consult your healthcare provider before using this or any product if you are pregnant or nursing, taking any medication or have a medical condition.

Do not use if seal is broken.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Herbal Supplement

Formula

Full Spectrum Sarsaparilla Root 450 mg per capsule

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Full Spectrum Sarsaparilla Root 450 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Full Spectrum Sarsaparilla Root 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Full Spectrum Sarsaparilla Root 450 mg by Swanson

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Sarsaparilla

Interacts with
2 drugs
900 mg per serving

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited...

Sarsaparilla monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Full Spectrum Sarsaparilla Root 450 mg by Swanson Drug Interactions

Want to check YOUR meds against Full Spectrum Sarsaparilla Root 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Sarsaparilla 2

Individual Drug Interactions

The ingredients in Full Spectrum Sarsaparilla Root 450 mg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Full Spectrum Sarsaparilla Root 450 mg interact with drugs. Each result below shows which ingredient is responsible. Sarsaparilla

Each ingredient & the kinds of drugs it affects

For each ingredient in Full Spectrum Sarsaparilla Root 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sarsaparilla2 drug types · 2 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of sarsaparilla with digoxin might increase the risk of cardiac toxicity.
Sarsaparilla is thought to have diuretic properties, which could potentially cause potassium loss. Overuse or misuse of sarsaparilla with cardiac glycoside therapy might increase the risk of cardiac toxicity due to potassium loss.

Likelihood Possible Evidence D
Lithium

Theoretically, sarsaparilla might increase the effects and adverse effects of lithium.
Sarsaparilla is thought to have diuretic properties. Due to these effects, sarsaparilla might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Sarsaparilla full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Full Spectrum Sarsaparilla Root 450 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

Full Spectrum Sarsaparilla Root 450 mg by Swanson: Common Questions

Does Full Spectrum Sarsaparilla Root 450 mg by Swanson interact with any medications?
Yes. Based on its ingredients, Full Spectrum Sarsaparilla Root 450 mg has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Full Spectrum Sarsaparilla Root 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take sarsaparilla if I'm pregnant or breastfeeding?
The safety data advise against it. There isn't enough information to know whether it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
What does sarsaparilla actually do?
It's a traditional herbal root used for various health concerns—cancer, psoriasis, and rheumatoid arthritis among them—but the evidence we have shows insufficient reliable data to rate how well it works for any of these. If you're considering it for a specific reason, ask your doctor what the science says.
Is sarsaparilla safe as a supplement?
It's thought to be low-risk at food amounts, but human safety data for supplement doses are limited. We don't have a lot of real-world safety information yet. If you have existing health conditions or take medications, check with your pharmacist first.
What are the inactive ingredients in this product?
The capsule contains gelatin, microcrystalline cellulose, magnesium stearate, and silica—all standard binders and flow agents that help the capsule hold together and flow through manufacturing.
Will sarsaparilla interact with my heart medication?
If you take digoxin (Lanoxin), yes—it's a documented Moderate interaction. Sarsaparilla's diuretic effect can lower potassium, which may increase heart-related toxicity risk with that drug. Check with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Full Spectrum Sarsaparilla Root 450 mg label
Go deeper

The Full Monographs Behind Full Spectrum Sarsaparilla Root 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sarsaparilla

Interacts with 2 drugs

Sarsaparilla is a traditional root used in teas, tonics, and old-fashioned root beer flavoring. Modern evidence for its health claims is very limited and comes mostly from lab studies, so it...

Read the full Sarsaparilla monograph →
Sources

Sources & How We Checked

Full Spectrum Sarsaparilla Root 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sarsaparilla 3 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Vandenplas O, Depelchin S, Toussaint G, et al. Occupational asthma caused by sarsaparilla root dust. J Allergy Clin Immunol 1996;97:1416-8. PubMed

See these in context on the Sarsaparilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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