Garcinia MD Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Garcinia MD against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Garcinia MD is a dietary supplement by Approved Science with 2 active ingredients. Its ingredients are commonly taken for weight loss, appetite suppression, curbing sugar and carb cravings.Based on those ingredients, 760 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Garcinia cambogia Fruit Rind Extract, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Garcinia MD by Approved Science
Ask about any prescription or over-the-counter medication and we check it for interactions with Garcinia MD by Approved Science — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Garcinia MD by Approved Science
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Garcinia MD contains 2 active ingredients: Garcinia cambogia Fruit Rind Extract, which is the source of hydroxycitric acid (HCA), and Potassium. The product also includes cellulose as an inactive filler.
Does it work?
Not established
The evidence for garcinia cambogia in this product hasn't been established in our data for the conditions it's marketed toward — athletic performance, fatty liver disease, high cholesterol, and obesity all show insufficient reliable evidence to rate. Potassium's effectiveness data isn't on file for any specific health claims.
How safe is it?
Well-documented data
Garcinia is generally well tolerated in short-term use, but rare reports of liver injury warrant caution. The most common side effects from garcinia are diarrhea, gastrointestinal discomfort, headache, and nausea.
Serious but rare side effects include liver damage, mania (especially in people with bipolar disorder), pancreatitis, and one documented case of heart inflammation. Potassium from your diet is fine, but supplements can cause dangerously high blood potassium levels in some people, particularly those with kidney disease.
Common side effects from potassium supplements are abdominal pain, nausea, diarrhea, and gas. Don't use garcinia during pregnancy or while breastfeeding — there isn't enough safety data.
For potassium, dietary amounts are appropriate in pregnancy, but use supplements only under medical guidance; the same goes for breastfeeding.
Meds to double-check
Moderate interaction found
Before you take this, double-check any serotonergic drugs (antidepressants, certain pain relievers), blood thinners or antiplatelet drugs, diabetes medications, blood pressure drugs including ACE inhibitors, ARBs, and potassium-sparing diuretics, and any medications that can damage the liver.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
If you take antidepressants, blood thinners, diabetes medications, or blood pressure drugs — especially ACE inhibitors or ARBs — check your medications with the tool below before starting this product. The interaction profile is significant enough that a conversation with your pharmacist beforehand is wise.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Garcinia MD, straight from the product label.
| Brand | Approved Science |
|---|---|
| Barcode (UPC) | X0015Y5U0V |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 21, 2024 |
| DSLD ID | 319761 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Garcinia MD by Approved Science, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Garcinia cambogia Fruit Rind Extract | 1600 mg | -- |
| Potassium | 100 mg | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take two capsules daily, (one in the morning and one in the afternoon), before meals with an 8 oz. glass of water.
Precautions
Caution: Do not exceed recommended dose. Do not use if safety seal is damaged or missing.
Pregnant women or nursing mothers, children under 18, and individuals with a known medical condition, should consult with a physician before taking this or any other dietary supplement.
Pregnant women or nursing mothers, children under 18, and individuals with a known medical condition, should consult with a physician before taking this or any other dietary supplement. Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
Store at room temperature.
Formulation
Manufactured in the USA according to Good Manufacturing Practice (cGMP) and conforms to the tested ingredients grade, strength and purity of industry Quality Standards.
Vegan friendly
Made with GMO free ingredients
Advanced weight management support Premium grade High potency Safe Fast Natural formula Optimal strength GMP Certified
100% vegan friendly
Seals/Symbols
Vegan friendly Made in USA No animal testing GMP Good Manufacturing Practice Quality Product
Formula
Garcinia MD with 95% hydroxycitric acid (HCA)
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Garcinia MD by Approved Science label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Garcinia MD by Approved Science
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Garcinia cambogia Fruit Rind Extract
Interacts with704 drugs
Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...
Garcinia cambogia Fruit Rind Extract monograph & interactionsPotassium
Interacts with62 drugs
Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...
Potassium monograph & interactionsOther (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
Garcinia MD by Approved Science Drug Interactions
HelloPharmacist Interaction Report
Garcinia MD by Approved Science contains two active ingredients, and together they interact with a substantial number of medications.
The most serious concern is with serotonergic drugs (antidepressants, certain pain medications) — garcinia cambogia carries a Moderate severity risk of serotonin syndrome, a potentially dangerous buildup of serotonin in your body. One case report documented this in a patient taking escitalopram alongside garcinia extract.
Read the full breakdown — every affected drug type, severity by severity
Garcinia also raises Moderate concerns with blood thinners and antiplatelet drugs (like warfarin and aspirin), as its active compound may increase bleeding risk. It can theoretically increase the effect of diabetes medications and raise low blood sugar (hypoglycemia) risk.
Additionally, garcinia has been linked to rare liver damage, so combining it with other drugs that stress the liver warrants caution.
Potassium in this product interacts with blood pressure medications: ACE inhibitors, ARBs, and potassium-sparing diuretics all carry a Moderate risk of dangerously high potassium levels (hyperkalemia) when combined with supplements. Altogether, these interactions span 743 individual medications.
Before you start, use the medication checker below to confirm your exact prescriptions and supplements aren't on that list.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Garcinia MD?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Garcinia MD interact with 760 drugs. Click any drug to see the details.
2 of the 2 ingredients in Garcinia MD interact with drugs. Each result below shows which ingredient is responsible. Garcinia cambogia Fruit Rind Extract Potassium
Acetaminophen, MethocarbamolRobaxacet
How Acetaminophen, Methocarbamol interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Methocarbamol interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Orphenadrine interactionAcetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
How Acetaminophen, Oxycodone interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Oxycodone interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetohexamideDymelor
How Acetohexamide interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Acetylsalicylic Acid interactionAdagrasibKrazati
How Adagrasib interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Adagrasib interactionAlbiglutideTanzeum
How Albiglutide interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia Cambogia Fruit Rind Extract + Albiglutide interactionAldesleukinProleukin
How Aldesleukin interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Aldesleukin interactionAlectinib HydrochlorideAlecensa
How Alectinib Hydrochloride interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Alectinib Hydrochloride interactionAllopurinolCaplenal, Cosuric, Rimapurinol, Zyloprim, Zyloric
How Allopurinol interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Allopurinol interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Fruit Rind Extract + Almotriptan interactionAlogliptinNesina
How Alogliptin interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia Cambogia Fruit Rind Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia Cambogia Fruit Rind Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Garcinia Cambogia Fruit Rind Extract + Alogliptin, Pioglitazone interactionAlosetronLotronex
How Alosetron interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractSerotonergic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Garcinia Cambogia Fruit Rind Extract + Alosetron interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Garcinia Cambogia Fruit Rind Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
Garcinia Cambogia Fruit Rind ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Garcinia Cambogia Fruit Rind Extract + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Garcinia MD — through 1 ingredient. Tap an ingredient for the detail:
PotassiumPotassium-sparing Diuretics Moderate
Interaction Summary
Concomitant use increases the risk of hyperkalemia.
Read the full Potassium + Amiloride interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Garcinia MD with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Garcinia cambogia Fruit Rind Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.
Antidiabetes Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.
Hepatotoxic Drugs
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.
Serotonergic Drugs
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Potassium
Ace Inhibitors (Aceis)
Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Angiotensin Receptor Blockers (Arbs)
Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.
Potassium-Sparing Diuretics
Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.
Brand information
Manufacturer and brand details for Garcinia MD, from the product label.
Approved Science
See all Approved Science products- Name
- Approved Science
- City
- New York
- State
- NY
- ZipCode
- 10003
- Phone Number
- 888-307-4790
- Web Address
- www.approvedscience.com
Garcinia MD by Approved Science: Common Questions
Does Garcinia MD by Approved Science interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on an antidepressant?
What are the most common side effects?
Is garcinia safe for weight loss?
Can I take this while breastfeeding?
Why is potassium in a weight-loss supplement?
Can I take this if I have kidney disease?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Garcinia MD is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Garcinia MD’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Garcinia
Interacts with 704 drugsGarcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...
Read the full Garcinia monograph → Herb & supplement monographPotassium
Interacts with 62 drugsPotassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...
Read the full Potassium monograph →Sources & How We Checked
Garcinia MD's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 56 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garcinia 44 references
- Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
- Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
- Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
- Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
- Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
- Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism 2004;53(1):66-72. PubMed
- Asghar M, Monjok E, Kouamou G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 2007;304(1-2):93-99. PubMed
- Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol 2005;288(6):G1144-G1149. PubMed
- Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition 2004;20(10):911-915. PubMed
- Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. PubMed
- Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91.
- Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94.
- Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. PubMed
- Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008 Dec 7;14(45):6999-7004. PubMed
- Sharma T, Wong L, Tsai N, Wong RD. Hydroxycut(®) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature. Hawaii Med J. 2010 Aug;69(8):188-90.
- Rashid NN, Grant J. Hydroxycut hepatotoxicity. Med J Aust. 2010 Feb 1;192(3):173-4. PubMed
- Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis. 2007 Oct;39(10):953-5. PubMed
- Corey R, Werner KT, Singer A, Moss A, Smith M, Noelting J, Rakela J. Acute liver failure associated with Garcinia cambogia use. Ann Hepatol. 2016 Jan-Feb;15(1):123-6. PubMed
- Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. PubMed
- García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. PubMed
- Dehoney S, Wellein M. Rhabdomyolysis associated with the nutritional supplement Hydroxycut. Am J Health Syst Pharm. 2009;66(2):142-8. PubMed
- Fong TL, Klontz KC, Canas-Coto A, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol. 2010;105(7):1561-6. PubMed
- Hendrickson BP, Shaikh N, Occhiogrosso M, Penzner JB. Mania Induced by Garcinia cambogia: A Case Series. Prim Care Companion CNS Disord. 2016;18(2).
- Kaswala D, Shah S, Patel N, Raisoni S, Swaminathan S. Hydroxycut-induced Liver Toxicity. Ann Med Health Sci Res. 2014; 4(1):143-5. PubMed
- Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol. 2009;15(14):1786-7. PubMed
- Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Dangerous dietary supplements: Garcinia cambogia -associated hepatic failure requiring transplantation. World J Gastroenterol. 2016;22(45):10071-10076.
- Narasimha A, Shetty PH, Nanjundaswamy MH, Viswanath B, Bada Math S. Hydroxycut - Dietary supplements for weight loss: Can they induce mania? Aust N Z J Psychiatry. 2013;47(12):1205-6. PubMed
- Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci. 2009;54(2):406-8. PubMed
- Stohs SJ, Preuss HG, Ohia SE, et al. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid. World J Gastroenterol. 2009;15(32):4087-9. PubMed
- Gavril A, Ribnikar M, Smid L, Luzar B, Stabuc B. Fat burner-induced acute liver injury: case series of four patients. Nutrition. 2018;47:110-114. doi: 10.1016/j.nut.2017.10.002. PubMed
- Bystrak T, Cervera-Hernandez ME, Reddy N, King Z, Bratberg J. Garcinia cambogia, diabetic ketoacidosis, and pancreatitis. R I Med J (2013). 2017 Oct 2;100(10):48-50. NO DOI
- Smith RJ, Bertilone C, Robertson AG. Fulminant liver failure and transplantation after use of dietary supplements. Med J Aust. 2016;204(1):30-2. PubMed
- Nguyen DC, Timmer TK, Davison BC, McGrane IR. Possible Garcinia cambogia-induced mania with psychosis: a case report. J Pharm Pract 2019;32(1):99-102. doi: 10.1177/0897190017734728.
- Yousaf MN, Chaudhary FS, Hodanazari SM, Sittambalam CD. Hepatotoxicity associated with Garcinia cambogia: a case report. World J Hepatol 2019;11(11):735-42.
- Mas Ordeig A, Bordón García N. Hepatotoxicity caused by Garcinia cambogia. Gastroenterol Hepatol 2020;43(3):134-5. DOI
- Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: case report. Eur J Ophthalmol 2019:1120672119872364. PubMed
- Ferreira V, Mathieu A, Soucy G, Giard JM, Erard-Poinsot D. Acute severe liver injury related to long-term Garcinia cambogia intake. ACG Case Rep J. 2020;7(8):e00429. PubMed
- Iqbal U, Anwar H, Siddiqui HU, Mehmood A. Acute Pancreatitis Secondary to Use of Appetite Suppressant: Garcinia cambogia. Cureus. 2019;11(5):e4676. PubMed
- Grigos A, Benmoussa J, Sandhu J, Chaucer B, Clarke M, SH Patel. Acute pancreatitis secondary to Garcinia cambogia; the unknown cost of herbal supplements. JOP. J Pancreas (Online) 2016; 17(3):316-317.
- Sidhu RLS, Labana S, Khehra L. Garcinia cambogia: a link between the "miracle" weight loss pill and acute pancreatitis. Am J Gastroenterol. 2016. 111:S560-S561. DOI
- Vuppalanchi R, Bonkovsky HL, Ahmad J, et al. Garcinia cambogia, Either Alone or in Combination With Green Tea, Causes Moderate to Severe Liver Injury. Clin Gastroenterol Hepatol 2021. PubMed
- Calaquian LL, Yau I. Garcinia cambogia-A Supplement-Related Liver Injury. Cureus 2022;14(2):e22225. PubMed
Potassium 12 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
- Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
- Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
- Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
- Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
- Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
- Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
- Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
- Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
- Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC