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Dietary supplement

Gas Ease Enzymes For Beans And Vegetables Ingredients & Drug Interactions

by Nutri-Essence

Gas Ease Enzymes For Beans And Vegetables label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gas Ease Enzymes For Beans And Vegetables against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gas Ease Enzymes For Beans And Vegetables is a dietary supplement by Nutri-Essence with 5 active ingredients.Based on those ingredients, 1,128 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence

Ask about any prescription or over-the-counter medication and we check it for interactions with Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 12 of its 17 active ingredients.
  • “Vegetarian Enzymes” is listed as a grouped ingredient — the label gives one combined amount (236 mg) without saying how much of each component you get.
  • “Carbohydrate-Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Protein-Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This product contains 17 ingredients, most of them digestive enzymes that break down carbohydrates, proteins, fats, and fiber in beans and vegetables. The active enzyme ingredients are amylase, protease, lipase, cellulase, glucoamylase, alpha-galactosidase, xylanase, pectinase, beta-glucanase, phytase, hemicellulase, and diastase.

It also includes caraway seed, peppermint leaf extract, and fennel seed extract for digestive support. The product contains two inactive ingredients: cellulose (plant-based) and water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Maximize digestion of legumes, vegetables, and fiber.
  • We looked for evidence on: Flatulence, Dyspepsia, Irritable bowel syndrome (IBS), Abdominal pain, Nausea and vomiting, Postoperative ileus — and 4 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Caraway is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Peppermint is rated "Possibly Effective" for Chemotherapy-induced nausea and vomiting (CINV), Dyspepsia.

The facts we hold don't establish how well this enzyme blend works for gas or bloating from beans and vegetables. Peppermint leaf is rated Possibly Effective for indigestion (dyspepsia), and Likely Effective for irritable bowel syndrome — so that component has some backing.

Caraway is rated Possibly Effective for dyspepsia. Fennel seed shows Possibly Effective for period pain (dysmenorrhea).

For the individual enzymes, the evidence we hold is insufficient to rate them — we don't have effectiveness data to confirm whether protease, lipase, or phytase, among others, actually reduce gas from these foods.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated but may cause digestive upset or allergic reactions in some people. Lipase is also generally well tolerated in supplement form, though those with serious digestive conditions should use it only with medical guidance.

Peppermint leaf is generally safe in tea and food amounts; the most common side effects from supplemental doses are abdominal pain, heartburn, nausea, and belching. A rare case of anaphylaxis (severe allergic reaction) has been reported.

Caraway is generally safe in food amounts but less studied at supplement doses. Fennel seed is well tolerated as a food but concentrated supplements are less studied; gastrointestinal discomfort and allergic reactions can occur, and rare cases of seizures have been reported.

Phytase carries limited safety data in humans, though occupational exposure to airborne phytase powder has caused allergic asthma and a hypersensitivity lung reaction.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Caraway, Fennel, Peppermint.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,129 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take CYP3A4 substrates (heart, blood pressure, immune-suppressing, or cancer drugs affected by peppermint), diabetes drugs, central nervous system depressants, diuretics, lithium, oral birth control, hormone replacement therapy, blood thinners, ciprofloxacin, or tuberculosis drugs. Peppermint and fennel are the main sources of these interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This enzyme blend is designed to ease gas and bloating from beans and vegetables. It's worth trying if you're looking for digestive support, but you must check your exact medications with the tool on this page before starting — peppermint and fennel in particular interact with a very large number of drugs.

Talk to your pharmacist if you take any heart, blood pressure, diabetes, birth control, blood thinner, or psychiatric medications, or if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 26, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gas Ease Enzymes For Beans And Vegetables, straight from the product label.

Brand Nutri-Essence
Barcode (UPC) 707636020715
Net contents 60 Vegetarian Capsule(s)
Market status Off market
Date entered into DSLD Apr 26, 2012
DSLD ID 7663
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
707636020715
IngredientAmount% DV
Amylase7000 DU--
Protease7800 HUT--
Lipase188 FIP--
Cellulase200 CU--
Glucoamylase12 AGU--
Alpha-Galactosidase600 GALU--
Xylanase1000 XU--
Pectinase6 Endo-PGU--
Beta-Glucanase8.16 BGU--
Phytase1.35 FTU--
Hemicellulase1500 HCU--
Diastase175 DP--
Caraway0 NP--
Vegetarian Enzymes236 mg--
Carbohydrate-Digesting Enzymes0 None--
Protein-Digesting Enzymes0 NP--
Fiber-Digesting Enzymes0 None--
Fat-Digesting Enzymes0 None--
Herbal Digestive Support260 mg--
Peppermint leaf extract0 NP--
Alkaline0 None--
Protease0 None--
Fennel seed extract0 NP--

Other ingredients: Cellulose, Plant, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nutri-Essence(TM) Gas Ease - Enzymes for Beans and Vegetables is a 100% vegetarian supplement providing enzymes derived from plant sources to help maximize the digestion of legumes (beans), cruciferous vegetables and high fiber foods, and a synergistic herbal blend for digestive support. A unique blend of enzymes enhances the release of nutrients from grains, fruits, vegetables and herbs. The herbal blend consists of standardized herbal extracts precisely combined with finely ground herbs. A European commission of 16 physicians has approved these herbs for optimum digestion.*

Suggested/Recommended/Usage/Directions

Directions: One capsule with each meal or snack containing legumes, vegetables or high fiber foods. Take with adequate liquid.

Storage

Store tightly closed in a cool, dry place.

Precautions

Use only if tamper-evident seal is unbroken.

Keep out of reach of children.

Formulation

Contains no wheat, yeast, corn proteins or animal products. No sweeteners, salt or artificial colors or flavors.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, mitigate, cure or prevent any disease.

FDA Statement of Identity

Enzyme Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gas Ease Enzymes For Beans And Vegetables label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vegetarian Enzymes

236 mg per serving
  • › Carbohydrate-Digesting Enzymes
  • › Protein-Digesting Enzymes
  • › Fiber-Digesting Enzymes
  • › Fat-Digesting Enzymes
  • › Herbal Digestive Support

Other (inactive) ingredients: Cellulose, Plant, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence Drug Interactions

Want to check YOUR meds against Gas Ease Enzymes For Beans And Vegetables?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,128Drugs
1,086 Moderate 42 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Gas Ease Enzymes For Beans And Vegetables interact with 1,128 drugs. Click any drug to see the details.

0 of the 5 ingredients in Gas Ease Enzymes For Beans And Vegetables interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Gas Ease Enzymes For Beans And Vegetables with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Gas Ease Enzymes For Beans And Vegetables, from the product label.

Nutri-Essence

See all Nutri-Essence products
Name
enzymes, inc.
City
Kansas City
State
MO
ZipCode
64153
Phone Number
800-647-6377
Pharmacist Counseling Corner

Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence: Common Questions

Does Gas Ease Enzymes For Beans And Vegetables by Nutri-Essence interact with any medications?
Yes. Based on its ingredients, Gas Ease Enzymes For Beans And Vegetables has a known interaction with 1,128 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gas Ease Enzymes For Beans And Vegetables contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with gas from beans?
This product is designed for that purpose and contains multiple enzymes to break down carbohydrates, proteins, and fiber. Peppermint and caraway in the blend are both rated possibly or likely effective for indigestion, though we don't have specific trial data proving the whole formula reduces bean-related gas.
Is peppermint in this product safe?
Peppermint leaf is generally well tolerated in the doses found in supplements. Most common side effects are mild — abdominal pain, heartburn, nausea, or belching. A rare case of severe allergic reaction has been reported. The main safety concern is interactions with medications your liver breaks down.
Can I take this if I'm on birth control?
The fennel seed in this product may theoretically weaken birth control pills because some of its compounds mimic estrogen. While this hasn't been proven in humans, if you're on hormonal contraception, mention this product to your pharmacist before starting it.
What does caraway do in this formula?
Caraway is included for digestive support — it's rated possibly effective for indigestion. However, animal research suggests it can lower blood sugar and act as a mild sedative, which is why it interacts with diabetes drugs and sedating medications.
Is it safe during pregnancy?
Peppermint leaf is rated likely safe, but caraway is rated possibly unsafe in medicinal amounts during pregnancy. Fennel and some enzymes lack enough safety data. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
What are the inactive ingredients?
This product contains only two inactive ingredients: plant-based cellulose and water — there are no other fillers or binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gas Ease Enzymes For Beans And Vegetables is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gas Ease Enzymes For Beans And Vegetables label
Sources

Sources & How We Checked

Gas Ease Enzymes For Beans And Vegetables's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 80 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Caraway 11 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  3. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  4. Herb Info Canada. Caraway website. www.herb.plant.org/caraway.htm (Accessed 11 September 2000).
  5. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  6. Eddouks M, Lemhardri A, Michel JB. Caraway and caper: potential anti-hyperglycaemic plants in diabetic rats. J Ethnopharmacol 2004;94:143-8. PubMed
  7. Sachin BS, Monica P, Sharma SC, et al. Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability. Hum Exp Toxicol. 2009;28(4):175-84. PubMed
  8. Lahlou, S., Tahraoui, A., Israili, Z., and Lyoussi, B. Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol. 4-4-2007;110(3):458-463. PubMed
  9. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  10. Modu S, Gohla K Umar IA. The hypoglycaemic and hypocholrsterolaemic properties of black caraway (Carum carvi L.) oil in alloxan diabetic rats. Biokemistri (Nigeria) 1997;7:91-97.
  11. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed

See these in context on the Caraway monograph →

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
  27. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115. DOI
  28. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  29. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  30. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  31. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375. PubMed
  32. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
  33. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed
  34. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1). PubMed
  35. Begas E, Tsioutsiouliti A, Kouvaras E, et al. Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers. Food Chem Toxicol 2017;100:80-9 PubMed
  36. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci 2016;61(2):560-71. PubMed
  37. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8. PubMed
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Fennel 17 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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