Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

GF-9 Ingredients & Drug Interactions

by Novex Biotech

GF-9 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GF-9 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

GF-9 is a dietary supplement by Novex Biotech with 6 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 1,127 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Schizonepeta, Powder, L-Arginine Hydrochloride, L-Cysteine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GF-9 by Novex Biotech

Ask about any prescription or over-the-counter medication and we check it for interactions with GF-9 by Novex Biotech — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of GF-9 by Novex Biotech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “GenysFactor Proprietary Blend” is a proprietary blend — the label gives one combined amount (2.90 Gram(s)) without saying how much of each component you get.

GF-9 contains six active ingredients: L-glutamine, L-lysine hydrochloride, L-cysteine, L-arginine hydrochloride, schizonepeta powder, and oxo-proline. These are amino acids and herbal components that the product markets for athletic recovery and performance.

The capsule also contains inactive ingredients—gelatin (the capsule shell), magnesium stearate, stearic acid, rice flour, microcrystalline cellulose, titanium dioxide, and silicon dioxide—which are fillers and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Glutamine) (Natural Medicines).
  • On file: Herpes labialis (cold sores) — rated "Possibly Effective" (Lysine) (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Glutamine) (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Glutamine) (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Glutamine) (Natural Medicines).

The evidence we hold is sparse and mixed. L-glutamine shows it is effective for sickle cell disease, and possibly effective for HIV/AIDS-related wasting and postoperative recovery.

L-lysine is possibly effective for cold sores. For the other ingredients—L-cysteine, L-arginine, oxo-proline, and schizonepeta—the data we have rates them as having insufficient reliable evidence or does not rate them for any condition.

The product as a whole has not been evaluated in our data for athletic performance or muscle recovery.

The evidence, ingredient by ingredient Glutamine Lysine L-cysteine L-arginine Schizonepeta

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is likely safe in pregnancy and lactation, but it's generally well tolerated in healthy adults; people with kidney or liver disease need medical supervision. Reported side effects include belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, headache, and gastrointestinal pain.

L-lysine is generally well tolerated at typical doses; pregnancy supplement safety is not well studied, and breastfeeding safety is unknown—check with your doctor. L-cysteine is likely safe in pregnancy and lactation but is generally well tolerated only in food amounts; high-dose supplement safety is not well studied.

L-arginine is often well tolerated short-term but can lower blood pressure and is not safe for everyone; it should be used only under medical supervision. Side effects can include abdominal pain, bloating, nausea, diarrhea, headache, and flushing.

Schizonepeta should be avoided in pregnancy and while breastfeeding. It's generally used in small amounts in traditional formulas, but high-quality human safety data are limited.

A combination product containing schizonepeta has been associated with nausea, vomiting, dizziness, headache, and dyspepsia, though it's unclear whether schizonepeta alone caused these.

Side effects, ingredient by ingredient Glutamine Lysine L-cysteine L-arginine Schizonepeta

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Lysine, L-arginine, Glutamine, Schizonepeta, L-cysteine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications.
  • For scale: 1,128 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GF-9, double-check these medication types with your pharmacist: blood pressure medications (especially ACE inhibitors and ARBs), blood thinners and antiplatelet drugs, drugs that affect potassium levels, diabetes medications, liver-metabolized medications including some antidepressants and pain relievers, and anticonvulsants. If you take any of these, do not start without talking to your pharmacist first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

GF-9 is a multi-ingredient supplement with significant medication interactions, especially if you take blood pressure or heart medications, blood thinners, diabetes drugs, liver-metabolized medications, or anticonvulsants. The evidence for its marketed uses is limited or absent in the data we hold.

Talk to your pharmacist or doctor before starting this product if you're on any prescription medications, and definitely check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GF-9, straight from the product label.

Brand Novex Biotech
Barcode (UPC) 856528001711
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 308346
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GF-9 by Novex Biotech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
856528001711
IngredientAmount% DV
L-Glutamine0 NP--
L-Lysine Hydrochloride0 NP--
L-Cysteine0 NP--
L-Arginine Hydrochloride0 NP--
GenysFactor Proprietary Blend2.9 Gram(s)--
Oxo-Proline0 NP--
Schizonepeta, Powder0 NP--

Other ingredients: Gelatin, Magnesium Stearate, Stearic Acid, Rice Flour, Microcrystalline Cellulose, Titanium Dioxide, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Adults take 4 capsules with water on an empty stomach, either in the morning 2 hours before breakfast, or 2 hours after dinner prior to bedtime. Do not eat or drink anything besides water two hours before or after taking GF-9. Do not exceed capsules in any 24-hour period. Individual results will vary.

Storage

This box was designed in an oversized manner to prevent pilferage.

Store at controlled room temperature: 15 degrees to 30 degrees C / 59 degrees to 86 degrees F

Precautions

Do not eat or drink anything besides water two hours before or after taking GF-9. Do not exceed capsules in any 24-hour period. Individual results will vary. Product resale allowed only through authorized representatives. International distribution is not authorized without prior written approval. Warning: Do not exceed suggested daily serving. Do not use if inner safety seal under the cap is broken or missing. Use only as directed.

Consult your physician before use if you are pregnant, nursing, taking medication, or if you have a medical condition.

Not for use in individuals under the age of 18 years. Keep out of reach of children.

Brand IP Statement(s)

Copyright 2022 All Rights Reserved

GF-9 is protected by U.S. Patent Numbers 8,551,542; 8,715,752; 8,722,114; 8,734,864; 8,747,921; 8,747,922; 8,765,195; 8,808,763; 8,808,764; 8,815,311; 9,066,953; 9,198,889; 9,238,023; 9,339,490; and Canadian Patent Number 2840809.

General Statements

Questions? 1-800-898-5153

Power your potential

Our products are built on a foundation of science and formulated to help power your potential. We partner with some of the most renowned research scientists to provide results-driven formulas with clinically studied ingredients. If you're looking to improve your drive and perform at your peak. Novex Biotech is your solution. Rigorous science Clinically validated ingredients Innovative formulations

The capsule shown is actual size.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Satisfaction guarantee: Try GF-9 risk-free with our money-back guarantee. For details, visit novexbiotech.com. Boosts natural human growth hormone levels up to 682%. HGH is associated with: Increased lean muscle Improved energy Reduced body fat Improved sleep HGH Booster Innovation Research

GF-9 stimulated natural high 682% increase in HGH serum (blood) levels In a crossover, placebo-controlled-double blind, randomized clinical trial, subject's serum (blood) HGH levels increased by a mean 682% just 2 hours after a single serving of GF-9. HGH is associated with: Physical performance Recovery & improved sleep Reduced body fat Muscle mass Libido Energy Endurance Immune support

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GF-9 by Novex Biotech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GF-9 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GF-9 by Novex Biotech

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

GenysFactor Proprietary Blend

2.9 Gram(s) per serving

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Stearic Acid, Rice Flour, Microcrystalline Cellulose, Titanium Dioxide, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

GF-9 by Novex Biotech Drug Interactions

Want to check YOUR meds against GF-9?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,127Drugs
1,123 Moderate 4 Minor

Ingredients driving the most interactions

Schizonepeta, Powder 797
L-Arginine Hydrochloride 403
L-Cysteine 86
L-Glutamine 50
L-Lysine Hydrochloride 1

Individual Drug Interactions

The ingredients in GF-9 interact with 1,127 drugs. Click any drug to see the details.

5 of the 6 ingredients in GF-9 interact with drugs. Each result below shows which ingredient is responsible. Schizonepeta, Powder L-Arginine Hydrochloride L-Cysteine L-Glutamine L-Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in GF-9 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Schizonepeta, Powder4 drug types · 797 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 1A2. Theoretically, schizonepeta might increase the effects and side effects of CYP1A2 substrates.
Some substrates of CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2D6. Theoretically, schizonepeta might increase the effects and side effects of CYP2D6 substrates.
Some substrates of CYP2D6 include amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), and others.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, inhibits cytochrome P450 (CYP) 2E1. Theoretically, schizonepeta might increase the effects and side effects of CYP2E1 substrates.
Some substrates of CYP2E1 include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane).

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4. Theoretically, schizonepeta might decrease the effects of CYP3A4 substrates.
Some substrates of CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and numerous others.

Likelihood Possible Evidence D
Schizonepeta, Powder full monograph & interactions

L-Arginine Hydrochloride9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine Hydrochloride full monograph & interactions

L-Cysteine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that L-cysteine can have hypoglycemic effects.

Likelihood Possible Evidence D
L-Cysteine full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GF-9, from the product label.

Novex Biotech

See all Novex Biotech products
Name
Novex Biotech, LLC
City
Salt Lake City
State
UT
ZipCode
84116
Phone Number
1-800-898-5153
Web Address
www.NovexBiotech.com
Pharmacist Counseling Corner

GF-9 by Novex Biotech: Common Questions

Does GF-9 by Novex Biotech interact with any medications?
Yes. Based on its ingredients, GF-9 has a known interaction with 1,127 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GF-9 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is GF-9 safe to take if I'm pregnant?
L-glutamine and L-cysteine are rated likely safe in pregnancy. However, L-lysine supplement safety in pregnancy is not well studied, and schizonepeta should be avoided. Since this product contains an ingredient not recommended in pregnancy and others that are unstudied at supplement doses, talk with your doctor before taking it.
Can I take GF-9 while breastfeeding?
L-glutamine and L-cysteine are rated likely safe while breastfeeding. L-lysine safety while breastfeeding is unknown, and schizonepeta should be avoided. Because of these mixed ratings and the presence of schizonepeta, check with your doctor or pharmacist before starting.
What are the most common side effects of GF-9?
L-glutamine most commonly causes belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting. L-lysine can cause abdominal pain, diarrhea, and stomach upset. L-arginine may cause abdominal pain, bloating, nausea, diarrhea, headache, and flushing. Schizonepeta in combination products has been associated with nausea, dizziness, and headache, though it's not clear if schizonepeta alone is responsible.
Does GF-9 actually work for muscle growth or athletic performance?
The data we hold does not rate GF-9 or most of its ingredients for muscle growth or athletic performance. L-glutamine shows evidence for sickle cell disease and possibly for recovery from surgery or trauma, and L-lysine is possibly effective for cold sores—but we don't have evidence for the product's marketed athletic uses.
Is GF-9 safe for someone with diabetes?
L-cysteine and L-arginine both theoretically may lower blood sugar. If you take diabetes medication, combining GF-9 with it might increase your risk of low blood sugar. Do not take this product without talking to your doctor or pharmacist first.
What is oxo-proline in this product?
Oxo-proline is listed as one of the six active ingredients, but we hold no safety or interaction data for it. We cannot tell you what it does or whether it's safe. Ask your pharmacist if they have information about this ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GF-9 label
Go deeper

The Full Monographs Behind GF-9’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

L-cysteine

Interacts with 86 drugs

L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione. Most people get enough from food, and supplements are usually well tolerated, bu...

Read the full L-cysteine monograph → Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

Schizonepeta

Interacts with 797 drugs

Schizonepeta is a mint-family herb long used in traditional Chinese medicine, usually as part of combination formulas for colds, fevers, and itchy skin conditions. Modern human evidence is v...

Read the full Schizonepeta monograph →
Sources

Sources & How We Checked

GF-9's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 90 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
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L-cysteine 2 references
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L-arginine 66 references
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Schizonepeta 4 references
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