Major interaction on record — check this product against your medications before combining. Based on 7 of 9 ingredients. Check your meds →
Dietary supplement

GI Repair Powder Ingredients & Drug Interactions

by Vital Nutrients

GI Repair Powder label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GI Repair Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

GI Repair Powder is a dietary supplement by Vital Nutrients with 9 active ingredients. Its ingredients are commonly taken for tooth decay prevention, dry mouth, sugar substitute.Based on those ingredients, 2,092 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Slippery Elm, Powder, Aloe Vera leaf inner fillet extract, N-Acetyl Glucosamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against GI Repair Powder by Vital Nutrients

Ask about any prescription or over-the-counter medication and we check it for interactions with GI Repair Powder by Vital Nutrients — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of GI Repair Powder by Vital Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (5.11 Gram(s)) without saying how much of each component you get.

GI Repair Powder contains 9 ingredients, including a proprietary blend. The active components are Xylitol (a sugar alcohol used in some dental products), Rutin (a plant compound), Zinc, N-Acetyl Glucosamine (a compound derived from shellfish), L-Glutamine (an amino acid), Slippery Elm Powder (inner bark), and Aloe Vera leaf inner fillet extract.

We could not check Methylsulfonylmethane and Colostrum from our available data. The product contains no inactive fillers or other listed ingredients beyond the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support for gastrointestinal health and repair.
  • We looked for evidence on: Constipation, Diarrhea, Crohn disease, Cystic fibrosis, Chemotherapy-induced diarrhea, Antiretroviral-associated diarrhea — and 4 related terms.
  • The strongest evidence on file: Aloe is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Crohn disease, Radiation-induced diarrhea.
  • Also on file: Zinc is rated "Possibly Ineffective" for Cystic fibrosis.

Evidence varies widely by ingredient. Xylitol is likely effective for dental caries and possibly effective for ear infections (otitis media).

Zinc is effective for zinc deficiency and likely effective for Wilson disease. N-Acetyl Glucosamine is likely effective for osteoarthritis.

Aloe Vera gel is possibly effective for acne, burns, and several other conditions. Glutamine is effective for sickle cell disease and possibly effective for recovery after surgery or critical illness.

For most other claimed uses—including Rutin for inflammatory bowel disease, Slippery Elm for constipation or diarrhea, and several others—the evidence in our data is insufficient to rate.

The evidence, ingredient by ingredient Xylitol Rutin Glucosamine Glutamine Slippery Elm Aloe Zinc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Xylitol is generally well tolerated in food amounts but can cause digestive upset (diarrhea, bloating, flatulence) at high doses of 30–40 grams and is extremely toxic to dogs. Zinc is well tolerated below 40 mg daily; higher doses may cause nausea, metallic taste, or abdominal discomfort, and long-term high-dose use raises concern for copper deficiency.

N-Acetyl Glucosamine is generally well tolerated orally but carries rare risk of allergic reactions including anaphylaxis; some cases of asthma flare-ups have been reported. Aloe Vera gel applied topically is well tolerated, but oral aloe latex can cause cramping and diarrhea and should be avoided in pregnancy and breastfeeding.

Rutin safety data for supplement doses are limited; it may cause headache, flushing, or rash in some people and is not recommended during breastfeeding. Glutamine is generally well tolerated in healthy adults but should be used only under medical supervision if you have kidney or liver disease.

Slippery Elm is generally well tolerated short-term but has limited long-term safety data; safety during pregnancy and breastfeeding is not well established.

Side effects, ingredient by ingredient Xylitol Rutin Glucosamine Glutamine Slippery Elm Aloe Zinc

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Rutin, Aloe, Glucosamine, Glutamine, Slippery Elm, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications.
  • For scale: 2,093 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take any of these: blood thinners or antiplatelet drugs (warfarin, aspirin), heart medications (digoxin), antibiotics (especially quinolone, tetracycline, or cephalexin types), penicillamine, HIV medications (ritonavir, integrase inhibitors like dolutegravir, or bictegravir-based combinations), chemotherapy drugs (cisplatin or topoisomerase II inhibitors), diabetes medications, anticonvulsant (seizure) drugs, diuretics, or stimulant laxatives. Slippery Elm may slow absorption of any oral medication, so spacing doses with other drugs may be necessary.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

GI Repair Powder is a multi-ingredient supplement with broad potential interactions, especially if you take blood thinners, heart medications, antibiotics, diabetes drugs, anticonvulsants, or HIV medications. Before you start it, run your exact prescriptions through the medication checker on this page and talk it over with your doctor or pharmacist.

If you're pregnant or breastfeeding, check with your healthcare provider first—safety data for several ingredients in this combination are limited or advise against use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GI Repair Powder, straight from the product label.

Brand Vital Nutrients
Barcode (UPC) 693465447116
Net contents 206 Gram(s); 7.26 Ounce(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 304989
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GI Repair Powder by Vital Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.58 Gram(s)
Maximum serving Sizes:
5.15 Gram(s)
Servings per container
40
UPC/BARCODE
693465447116
IngredientAmount% DV
Proprietary Blend5.11 Gram(s)--
Xylitol0 NP--
Rutin0 NP--
Methylsulfonylmethane0 NP--
Zinc5.5 mg50%
N-Acetyl Glucosamine0 NP--
L-Glutamine, Powder0 NP--
Slippery Elm, Powder0 NP--
Aloe Vera leaf inner fillet extract0 NP--
Colostrum0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store sealed in a cool dry place

Precautions

Keep out of reach of children

Use only if safety seal is intact

Warning: If pregnant, consult your physician before taking.

Inner seal may lift off when cap is removed. Seal integrity is maintained until cap is removed.

Contains: Lobster, crab, and/or shrimp Contains: milk

Suggested/Recommended/Usage/Directions

Recommendations: 1/2 to 1 rounded teaspoon 2-3 times daily, or as directed by your healthcare practitioner.

Formulation

Excludes coatings, binders, gluten (wheat, rye, barley), soy protein, egg protein, sugar. Verified by independent testing

Raw materials and finished products are independently tested by U.S. labs.

General Statements

Learn more at vitalnutrients.net

Formula

OptiMSM

Brand IP Statement(s)

OptiMSM is a registered trademark of Bergstrom Nutrition.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GI Repair Powder by Vital Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GI Repair Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GI Repair Powder by Vital Nutrients

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.58 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

5.11 Gram(s) per serving

Zinc

Interacts with
67 drugs
5.5 mg per serving Form: Zinc Carnosine

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions
Interaction report

GI Repair Powder by Vital Nutrients Drug Interactions

Want to check YOUR meds against GI Repair Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,092Drugs
3 Major 2,082 Moderate 7 Minor

Ingredients driving the most interactions

Slippery Elm, Powder 2,022
Aloe Vera leaf inner fillet extract 461
N-Acetyl Glucosamine 170
Rutin 86
Zinc 67

Individual Drug Interactions

The ingredients in GI Repair Powder interact with 2,092 drugs. Click any drug to see the details.

6 of the 9 ingredients in GI Repair Powder interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm, Powder Aloe Vera leaf inner fillet extract N-Acetyl Glucosamine Rutin Zinc L-Glutamine, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in GI Repair Powder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm, Powder1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm, Powder full monograph & interactions

Aloe Vera leaf inner fillet extract7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe Vera leaf inner fillet extract full monograph & interactions

N-Acetyl Glucosamine4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
N-Acetyl Glucosamine full monograph & interactions

Rutin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

L-Glutamine, Powder1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GI Repair Powder, from the product label.

Vital Nutrients

See all Vital Nutrients products
Name
Vital Nutrients
Street Address
34 Kenneth Dooley Drive
City
Middletown
State
CT
ZipCode
06457
Pharmacist Counseling Corner

GI Repair Powder by Vital Nutrients: Common Questions

Does GI Repair Powder by Vital Nutrients interact with any medications?
Yes. Based on its ingredients, GI Repair Powder has a known interaction with 2,092 medications, including 3 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GI Repair Powder contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product contain any ingredients I might be allergic to?
N-Acetyl Glucosamine is derived from shellfish, so if you have a shellfish allergy, check with your pharmacist first. Glucosamine products have also been linked to rare allergic reactions including anaphylaxis in sensitive individuals. Slippery Elm pollen can trigger reactions in people with pollen allergies.
Can I take this if I'm pregnant or breastfeeding?
Safety data vary by ingredient. Glutamine is likely safe in pregnancy, but N-Acetyl Glucosamine and Aloe Vera are not recommended—Aloe may stimulate the uterus and acts as a strong laxative. Rutin safety in pregnancy is not established, and it should be avoided while breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or nursing.
Will this help my digestive problems?
The ingredients are intended to support GI health, but evidence for most of them in treating specific digestive complaints—constipation, diarrhea, or inflammatory bowel disease—is insufficient in our data. Glutamine is possibly effective for recovery after critical illness, and some ingredients like Slippery Elm have a history of traditional use for gut comfort, but we can't confirm effectiveness for your particular condition.
What side effects might I experience?
The most common are gastrointestinal: bloating, constipation, diarrhea, nausea, and cramping—especially from Xylitol at high doses or from Aloe. Zinc may cause a metallic taste. Rutin may cause headache or skin flushing. Most people tolerate the product well at recommended doses, but if you experience persistent GI upset, stop and talk to your pharmacist.
Is this safe for dogs?
No. Xylitol, one of the ingredients in this powder, is highly toxic to dogs and can cause serious illness or death. Keep this product away from pets.
Does Zinc in this product affect how antibiotics work?
Yes—Zinc can reduce absorption and lower blood levels of several antibiotic types, including quinolones, tetracyclines, and cephalexin. If you're taking an antibiotic, ask your pharmacist about spacing the doses at least 2–6 hours apart, depending on the antibiotic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GI Repair Powder label
Go deeper

The Full Monographs Behind GI Repair Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Xylitol

Xylitol is a sugar alcohol used as a low-calorie sweetener that has the best-supported benefit for reducing cavities, especially in chewing gum or lozenges. It is generally safe for people i...

Read the full Xylitol monograph → Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph →
Sources

Sources & How We Checked

GI Repair Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 210 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Xylitol 7 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Weissman JD, Fernandez F, Hwang PH. Xylitol nasal irrigation in the management of chronic rhinosinusitis: a pilot study. Laryngoscope 2011;121:2468-72. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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