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Dietary supplement

Gluten Arrest Ingredients & Drug Interactions

by Promend

Gluten Arrest label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gluten Arrest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gluten Arrest is a dietary supplement by Promend with 1 active ingredient.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gluten Arrest by Promend

Ask about any prescription or over-the-counter medication and we check it for interactions with Gluten Arrest by Promend — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gluten Arrest by Promend

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “SEB Gluten Relief” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “DPP-IV” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Gluten Arrest contains eight active ingredients, most of them enzymes that help break down food. Lipase breaks down fats, papain and bromelain digest proteins, lactase breaks down milk sugar, cellulase digests plant fiber, alpha galactosidase reduces complex sugars, protease further breaks down proteins, and amylase digests starches.

The product also includes a proprietary blend and two additional formulations (SEB Gluten Relief and DPP-IV) whose exact composition isn't disclosed separately, so we can't detail their roles. The capsule also contains inactive ingredients — microcrystalline cellulose, magnesium stearate, maltodextrin, and hypromellose — which are fillers, binders, and the capsule shell itself.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: gluten digestion and digestive balance support.
  • We looked for evidence on: Celiac disease, Dyspepsia, Lactose intolerance, wheat sensitivity, gluten sensitivity.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia, Celiac disease.

The evidence we hold is limited. Lactase is effective for lactose intolerance — if you can't digest milk sugar, this enzyme does the job.

For the other active ingredients, the data shows insufficient reliable evidence to rate their effectiveness for digestive complaints like indigestion or inflammatory bowel disease. We don't have effectiveness ratings on file for protease, and the proprietary blends' individual components aren't broken out, so we can't assess their specific claims.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase, papain, bromelain, lactase, and protease are generally well tolerated short-term at appropriate doses, though allergic reactions can occur in sensitive people — especially to papain and bromelain, which may trigger itching, hives, or rarely respiratory symptoms with airborne exposure. High doses of papain can cause severe stomach irritation or esophageal perforation, and bromelain may cause diarrhea, gas, or stomach upset.

For pregnancy: concentrated papain and unripe papaya products should be avoided. Bromelain is best avoided — safety data is too limited.

Lactase is likely safe. Lipase, protease, and the others don't have enough data, so talk with your doctor before regular use in pregnancy.

For breastfeeding, papain and protease lack reliable safety data and aren't recommended without medical advice. Lactase has limited data but acts only in the gut; ask your doctor or pharmacist first.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Gluten Arrest, check with your doctor or pharmacist if you take warfarin or other anticoagulants (blood thinners). Also check if you take antiplatelet drugs like aspirin or clopidogrel — bromelain may increase bleeding risk.

If you take tetracycline antibiotics, confirm there's no issue, as bromelain may raise their levels. If you take a nonsteroidal anti-inflammatory like naproxen, talk it over too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gluten Arrest is a multi-enzyme digestive aid, most useful if you're deficient in one of these enzymes — especially lactase if you have trouble digesting milk. If you take warfarin, any blood thinner or antiplatelet drug, or tetracycline antibiotics, you need to check with your doctor or pharmacist before taking it.

The product is generally well tolerated but can trigger allergic reactions in sensitive people, and its effectiveness for general digestive complaints isn't well established in the data we hold.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gluten Arrest, straight from the product label.

Brand Promend
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 259730
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gluten Arrest by Promend, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lipase0 NP--
Papain0 NP--
Bromelain0 NP--
Lactase0 NP--
Cellulase0 NP--
Proprietary Enzyme Blend300 mg--
Alpha Galactosidase0 NP--
Protease0 NP--
SEB Gluten Relief0 NP--
DPP-IV0 NP--
Amylase0 NP--

Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Maltodextrin, Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Helps you enjoy your favorite foods!

Formulation

Gluten digestion support

Helps digest wheat & other grains Promotes digestive balance Defends against hidden gluten Breaks down gluten proteins Supports a gluten sensitive diet

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Proprietary DPP-IV Enzymes 30 fast acting capsules

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule with each meal or as directed by a health care professional.

Precautions

Produced in a facility that also processes soy, fish, shellfish, milk, peanuts, tree nuts, wheat, eggs.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gluten Arrest by Promend label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gluten Arrest label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gluten Arrest by Promend

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Proprietary Enzyme Blend

300 mg per serving
  • › SEB Gluten Relief

Other (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Maltodextrin, Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gluten Arrest by Promend Drug Interactions

Want to check YOUR meds against Gluten Arrest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

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141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Gluten Arrest interact with 141 drugs. Click any drug to see the details.

0 of the 1 ingredient in Gluten Arrest interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Gluten Arrest with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Gluten Arrest, from the product label.

Promend

See all Promend products
Name
Windmill Health Products
Pharmacist Counseling Corner

Gluten Arrest by Promend: Common Questions

Does Gluten Arrest by Promend interact with any medications?
Yes. Based on its ingredients, Gluten Arrest has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gluten Arrest contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I have gluten sensitivity?
We don't have effectiveness data on file showing whether Gluten Arrest works for gluten sensitivity or celiac disease. The enzymes are designed to aid general digestion, but whether they're specifically helpful for gluten reactions isn't established in our data. Talk with your doctor or dietitian about whether this product fits your situation.
Can I take this if I'm pregnant?
It depends on which ingredient you're most concerned about. Papain and bromelain should be avoided — safety data is too limited or suggests risk. Lactase is likely safe. For lipase, protease, and the others, there isn't enough reliable data to know either way. Check with your doctor before regular use in pregnancy.
What's papain, and why does it interact with warfarin?
Papain is an enzyme from papaya that digests proteins. It's thought to increase how much warfarin your body absorbs or how long it stays active, which can make your blood too thin and raise your bleeding risk. One patient's blood thinner level jumped dangerously after taking papain, so this isn't theoretical.
Can I breastfeed while taking this?
Papain and protease don't have enough safety data during breastfeeding and aren't recommended without medical advice. Lactase has limited data but acts only in the gut, so ask your doctor or pharmacist. For the other ingredients, we either have limited data or none on file.
What are the most common side effects?
The most common are digestive complaints like diarrhea, gas, stomach upset, or headache. Allergic reactions (itching, hives, watery eyes, sneezing) can happen in people sensitive to papain or bromelain, and rarely, occupational inhalation has triggered asthma or throat symptoms.
Is this safe for long-term use?
Short-term use at appropriate doses is generally well tolerated, but we don't have enough data on long-term safety. If you're thinking of taking it regularly, talk with your doctor or pharmacist first, especially if you have a serious digestive condition.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gluten Arrest is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gluten Arrest label
Sources

Sources & How We Checked

Gluten Arrest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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