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Dietary supplement

gPLC Glycine Propionyl L-Carnitine Ingredients & Drug Interactions

by Solgar

gPLC Glycine Propionyl L-Carnitine label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking gPLC Glycine Propionyl L-Carnitine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

gPLC Glycine Propionyl L-Carnitine is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Propionyl L-Carnitine, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against gPLC Glycine Propionyl L-Carnitine by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with gPLC Glycine Propionyl L-Carnitine by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of gPLC Glycine Propionyl L-Carnitine by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “GlycoCarn Glycine Propionyl L-Carnitine HCl” is listed as a grouped ingredient — the label gives one combined amount (925 mg) without saying how much of each component you get.

This product contains two active ingredients. Glycine is an amino acid; the product lists it as possibly effective for schizophrenia, though evidence for other uses — ADHD, benign prostatic hyperplasia, cystic fibrosis, and a rare enzyme deficiency — is insufficient.

Propionyl-L-carnitine is a compound derived from the amino acid carnitine and is listed as possibly effective for heart-related conditions including congestive heart failure, angina, and cardiovascular disease, as well as ulcerative colitis. The tablet also contains inactive ingredients (microcrystalline cellulose, vegetable cellulose, silica, vegetable magnesium stearate, and vegetable glycerin) that serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Angina — rated "Possibly Effective" (Propionyl-l-carnitine) (Natural Medicines).
  • On file: Cardiovascular disease (CVD) — rated "Possibly Effective" (Propionyl-l-carnitine) (Natural Medicines).
  • On file: Congestive heart failure (CHF) — rated "Possibly Effective" (Propionyl-l-carnitine) (Natural Medicines).
  • On file: Ulcerative colitis — rated "Possibly Effective" (Propionyl-l-carnitine) (Natural Medicines).
  • On file: Intermittent claudication — rated "Possibly Effective" (Propionyl-l-carnitine) (Natural Medicines).

Glycine is rated possibly effective for schizophrenia. For ADHD, benign prostatic hyperplasia, cystic fibrosis, and a rare enzyme deficiency called 3-phosphoglycerate dehydrogenase deficiency, the evidence we hold is insufficient to rate it either way.

Propionyl-L-carnitine is rated possibly effective for congestive heart failure, angina, cardiovascular disease, and ulcerative colitis. These ratings mean there's some evidence these uses may work, but more research would help confirm it.

The evidence, ingredient by ingredient Glycine Propionyl-l-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rarely, it's caused mild sedation, and GI symptoms like soft stools, nausea, vomiting, and upper stomach discomfort — all of which resolve quickly if you stop taking it.

Other reported symptoms (irritability, insomnia, fatigue, memory problems, headache, and dry mouth) have been noted, but whether they're actually caused by glycine isn't clear. Propionyl-L-carnitine is well tolerated short-term.

The most common side effects are diarrhea, stomach pain, nausea, and vomiting. A metabolite can cause a fishy odor in urine, breath, and sweat.

In clinical trials, bronchitis and back pain occurred more often with propionyl-L-carnitine than placebo. Propionyl-L-carnitine is best avoided in pregnancy; breastfeeding safety data are insufficient, so caution is advised while nursing.

Glycine safety data during pregnancy and breastfeeding are insufficient — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Glycine Propionyl-l-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Propionyl-l-carnitine, Glycine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use blood thinners (anticoagulants) like warfarin or acenocoumarol, clozapine (an antipsychotic), or thyroid hormone replacement — all have documented Moderate interactions with ingredients here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with certain heart conditions and ulcerative colitis, though evidence is still developing. If you take clozapine, warfarin, acenocoumarol, or thyroid hormone, this product isn't a fit without checking with your pharmacist or doctor first.

Even if you don't take those medications, search your complete medication list on this page before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about gPLC Glycine Propionyl L-Carnitine, straight from the product label.

Brand Solgar
Barcode (UPC) 033984013735
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214377
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for gPLC Glycine Propionyl L-Carnitine by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
033984013735
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Glycine210 mg--
Propionyl L-Carnitine600 mg--
GlycoCarn Glycine Propionyl L-Carnitine HCl925 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's Glycine Propionyl L-Carnitine Tablets are free of corn, yeast, wheat, soy and dairy products and are formulated without the use of artificial preservatives, flavors or colors.

Suitable for vetetarians

Sugar, salt and starch free

Storage

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Precautions

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Do not use if outer bottle seal is missing, torn or damaged in any way.

Formula

Solgar's KOF-K certification #K-1250

Brand IP Statement(s)

GlycoCarn is a registered trademark of Sigma-Tau Industries, S.p.A. and patented under U.S. patent # 6,703,042 B1.

General Statements

For more information, call toll-free 1-877-SOLGAR 4 www.solgar.com Solgar since 1947

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

K Parve (Kosher)

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) tablet daily with water, between meals, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

gPLC Glycine Propionyl L-Carnitine by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

gPLC Glycine Propionyl L-Carnitine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in gPLC Glycine Propionyl L-Carnitine by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

GlycoCarn Glycine Propionyl L-Carnitine HCl

925 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

gPLC Glycine Propionyl L-Carnitine by Solgar Drug Interactions

Want to check YOUR meds against gPLC Glycine Propionyl L-Carnitine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Moderate

Ingredients driving the most interactions

Propionyl L-Carnitine 19
Glycine 1

Individual Drug Interactions

The ingredients in gPLC Glycine Propionyl L-Carnitine interact with 20 drugs. Click any drug to see the details.

2 of the 2 ingredients in gPLC Glycine Propionyl L-Carnitine interact with drugs. Each result below shows which ingredient is responsible. Propionyl L-Carnitine Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in gPLC Glycine Propionyl L-Carnitine with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Propionyl L-Carnitine3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, propionyl-L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine, the parent compound of propionyl-L-carnitine, might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation when L-carnitine was taken with acenocoumarol. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product. It is unclear if such an interaction would also occur with propionyl-L-carnitine.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism. It is unclear if such an interaction would occur with propionyl-L-carnitine.

Likelihood Possible Evidence B
Warfarin (Coumadin)

Theoretically, propionyl-L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine, the parent compound of propionyl-L-carnitine, might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with propionyl-L-carnitine and warfarin.

Likelihood Possible Evidence D
Propionyl L-Carnitine full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for gPLC Glycine Propionyl L-Carnitine, from the product label.

Solgar

See all Solgar products
Name
Solgar Vitamin and Herb
Street Address
500 Willow Tree Road
City
Leonia
State
N.J.
ZipCode
07605
Phone Number
1-877-765-4234
Web Address
www.solgar.com
Pharmacist Counseling Corner

gPLC Glycine Propionyl L-Carnitine by Solgar: Common Questions

Does gPLC Glycine Propionyl L-Carnitine by Solgar interact with any medications?
Yes. Based on its ingredients, gPLC Glycine Propionyl L-Carnitine has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
gPLC Glycine Propionyl L-Carnitine contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take during pregnancy?
Propionyl-L-carnitine is best avoided in pregnancy because safety hasn't been established. Glycine safety data during pregnancy are also insufficient. Talk with your doctor or pharmacist about whether this product is right for you.
Is it safe while breastfeeding?
Propionyl-L-carnitine should be avoided while breastfeeding due to insufficient safety data. Glycine also lacks enough reliable safety information during breastfeeding, so caution is advised. Discuss with your healthcare provider before using.
What are the most common side effects?
The most common side effects come from propionyl-L-carnitine and include diarrhea, stomach pain, nausea, and vomiting. One metabolite can cause a fishy odor in urine, breath, and sweat. Most side effects are mild, but tell your pharmacist if they don't resolve.
Will this help my heart condition?
Propionyl-L-carnitine is rated possibly effective for congestive heart failure, angina, and cardiovascular disease — meaning there's some evidence it may help, but more research is needed. Talk with your doctor about whether it fits your specific situation.
Does the product contain any fillers?
Yes. The inactive ingredients include microcrystalline cellulose, vegetable cellulose, silica, vegetable magnesium stearate, and vegetable glycerin, which serve as binders and fillers.
Is glycine the same as glycine supplements sold separately?
This product contains glycine as one of two active ingredients, paired with propionyl-L-carnitine. The amount and form here may differ from standalone glycine supplements — check the label or ask your pharmacist about the dose in this formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

gPLC Glycine Propionyl L-Carnitine label
Go deeper

The Full Monographs Behind gPLC Glycine Propionyl L-Carnitine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Propionyl-l-carnitine

Interacts with 19 drugs

Propionyl-l-carnitine is a form of the amino acid derivative carnitine that the body uses to help turn fat into energy, and it is studied mostly for circulation problems like peripheral arte...

Read the full Propionyl-l-carnitine monograph →
Sources

Sources & How We Checked

gPLC Glycine Propionyl L-Carnitine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Propionyl-l-carnitine 12 references
  1. Cherchi A, Lai C, Onnis E, et al. Propionyl carnitine in stable effort angina. Cardiovasc Drugs Ther 1990;4:481-6. PubMed
  2. Bartels GL, Remme WJ, den Hartog FR, et al. Additional anti-ischemic effects of long-term L-propionylcarnitine in anginal patients treated with conventional antianginal therapy. Cardiovasc Drugs Ther 1995;9:749-53.
  3. Caponnetto S, Canale C, Masperone MA, et al. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. Eur Heart J 1994;15:1267-73. PubMed
  4. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  5. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  6. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  7. Gentile V, Vicini P, Prigiotti G, et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. Curr Med Res Opin 2004;20:1377-84. PubMed
  8. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  9. Brass EP, Koster D, Hiatt WR, Amato A. A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication. Vasc Med 2013;18:3-12.
  10. Hiatt WR, Creager MA, Amato A, Brass EP. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. J Cardiopulm Rehabil Prev 2011;31:125-32. PubMed
  11. Jacobs PL, Goldstein ER, Blackburn W, et al. Glycine propionyl-L-carnitine produces enhanced anaerobic work capacity with reduced lactate accumulation in resistance trained males. J Int Soc Sports Nutr 2009;6:9. PubMed
  12. Jacobs PL, Goldstein ER. Long-term glycine propionyl-l-carnitine supplementation and paradoxical effects on repeated anaerobic sprint performance. J Int Soc Sports Nutr 2010;7:35.

See these in context on the Propionyl-l-carnitine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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