Major interaction on record — check this product against your medications before combining. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Natural Advanced Carotenoid Complex Ingredients & Drug Interactions

by Solgar

Natural Advanced Carotenoid Complex label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Advanced Carotenoid Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Natural Advanced Carotenoid Complex is a dietary supplement by Solgar with 4 active ingredients. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 459 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin A, Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Advanced Carotenoid Complex by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Advanced Carotenoid Complex by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Advanced Carotenoid Complex by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains four active ingredients: vitamin A, lutein, zeaxanthin, and a carotenoid blend. These are all fat-soluble plant pigments (carotenoids) that your body uses for vision and eye health.

The remaining ingredients are the softgel capsule itself and inert carriers — gelatin, safflower oil, vegetable glycerin, beeswax, paprika, soy lecithin, titanium dioxide, and vitamin E.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: antioxidant protection.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Vitamin A is effective for vitamin A deficiency and possibly effective for oral leukoplakia (a precancerous mouth condition), aging skin, measles, ulcerative colitis, and a lung condition in premature infants. Lutein is possibly effective for age-related macular degeneration and cataracts, but possibly ineffective for retinitis pigmentosa, a serious eye disease, and for two conditions affecting premature infants.

Zeaxanthin is possibly effective for age-related macular degeneration, but evidence is insufficient to rate it for cognitive decline, Alzheimer's disease, asthma, breast cancer, or premature infant lung disease. We hold no effectiveness data for the carotenoid blend on its own.

The evidence, ingredient by ingredient Vitamin A Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin A is generally well-tolerated at recommended doses, but high doses are toxic because the body stores it in fat and can't easily clear excess. The safety data advises caution with high-dose vitamin A in pregnancy because it can cause birth defects — recommended amounts are fine, but high-dose supplements should be avoided unless a clinician directs otherwise.

Serious side effects at very high doses are rare but can include brain swelling, liver damage, coma, and even death; chronic overuse can cause fatigue, dry or peeling skin, hair loss, and brittle nails. Young children are more vulnerable than adults to toxicity from a single large dose.

Lutein from food and typical supplement doses is considered generally well-tolerated, and doses up to 20 mg daily have not caused adverse effects in trials. Lutein is naturally present in breast milk; safety of higher supplement doses during pregnancy and breastfeeding isn't well studied, so caution is advised.

Zeaxanthin is generally well-tolerated at typical supplement amounts, though its safety in pregnancy and breastfeeding has not been well studied — food sources are fine, but concentrated supplements warrant caution.

Side effects, ingredient by ingredient Vitamin A Lutein Zeaxanthin

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Vitamin A, Zeaxanthin.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 460 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, check with your doctor or pharmacist if you take retinoid medications (prescription vitamin A derivatives), blood thinners like warfarin, tetracycline antibiotics, diabetes medications, or any drugs known to affect your liver. These interactions with vitamin A and zeaxanthin are documented and may affect how those medications work or raise your risk of side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help with age-related eye conditions and vitamin A deficiency, depending on which ingredient you're counting on. If you take any prescription retinoids, blood thinners, tetracycline antibiotics, diabetes drugs, or medications that stress your liver, you'll want to check with your own doctor or pharmacist before starting — the interaction risks are real at higher doses.

Talk it over with them to see if the dose and timing work with your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Advanced Carotenoid Complex, straight from the product label.

Brand Solgar
Barcode (UPC) 033984000353
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Apr 24, 2015
DSLD ID 44384
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Advanced Carotenoid Complex by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
033984000353
IngredientAmount% DV
Calories5 {Calories}--
Vitamin A10000 IU200%
Total Fat0.5 Gram(s)1%
Lutein2 mg--
Zeaxanthin80 mcg--
Carotenoid Blend3 mg--

Other ingredients: Gelatin, Safflower Oil, Vegetable Glycerin, yellow Beeswax, Paprika, Soy Lecithin, Titanium Dioxide, D-Alpha-Tocopherol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Carotenoids are powerful antioxidants. Scientific research documents the ability of plant-based, antioxidant carotenoids to fight free radicals, which can contribute to oxidative stress and the premature aging of cells. That is why it is important to get a good balance of mixed carotenoids every day.

Since 1947

ANTIOXIDANT PROTECTION*

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

(C)2010 Solgar, Inc.

General

SOLGB16108 00B

Formulation

GLUTEN, WHEAT & DAIRY FREE

FREE OF: Gluten, Wheat, Dairy, Yeast, Sugar, Sodium, Artificial Flavor, Sweetener and Preservatives.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement for adults, take one (1) softgel up to two (2) times daily, preferably at mealtimes, or as directed by a healthcare practitioner.

Precautions

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Do not use if outer bottle seal is missing, torn or damaged in any way.

Storage

Store in a cool, dry place.

Formula

This broad-spectrum carotenoid formulation is offered in oil-based softgels to promote optimal absorption and assimilation.*

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Advanced Carotenoid Complex by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Advanced Carotenoid Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Advanced Carotenoid Complex by Solgar

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin A

Interacts with
387 drugs
10000 IU per serving Form: Beta-Carotene

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Lutein

No known
interactions
2 mg per serving Form: Marigold

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
80 mcg per serving Form: Marigold

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Carotenoid Blend

3 mg per serving Form: Alpha-Carotene, Gamma-Carotene

Other (inactive) ingredients: Gelatin, Safflower Oil, Vegetable Glycerin, Yellow Beeswax, Paprika, Soy Lecithin, Titanium Dioxide, D-Alpha-Tocopherol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Advanced Carotenoid Complex by Solgar Drug Interactions

Want to check YOUR meds against Natural Advanced Carotenoid Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
459Drugs
9 Major 450 Moderate

Ingredients driving the most interactions

Vitamin A 387
Zeaxanthin 86

Individual Drug Interactions

The ingredients in Natural Advanced Carotenoid Complex interact with 459 drugs. Click any drug to see the details.

2 of the 4 ingredients in Natural Advanced Carotenoid Complex interact with drugs. Each result below shows which ingredient is responsible. Vitamin A Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Advanced Carotenoid Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Advanced Carotenoid Complex, from the product label.

Solgar

See all Solgar products
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Natural Advanced Carotenoid Complex by Solgar: Common Questions

Does Natural Advanced Carotenoid Complex by Solgar interact with any medications?
Yes. Based on its ingredients, Natural Advanced Carotenoid Complex has a known interaction with 459 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Advanced Carotenoid Complex contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
The vitamin A in this product carries conflicting data — it's rated likely safe at recommended amounts but possibly unsafe at high doses because it can cause birth defects. Lutein and zeaxanthin are rated likely safe, though supplement safety during breastfeeding hasn't been well studied. Talk with your doctor or pharmacist about the specific dose and timing for your situation.
What does each ingredient in here actually do?
Vitamin A supports vision, immune function, and skin health. Lutein and zeaxanthin are pigments that concentrate in the retina (the light-sensing part of your eye) and may protect against age-related damage. All three are carotenoids — compounds your body can't make on its own, so you need them from food or supplements.
Can this really help prevent cataracts or macular degeneration?
Lutein is possibly effective for both; zeaxanthin is possibly effective for macular degeneration but the evidence for cataracts is less clear. Neither is proven to prevent these conditions outright, but they may play a protective role as part of your overall diet and lifestyle.
What happens if I take too much vitamin A from this?
High doses of vitamin A build up in your body over time because you can't excrete the excess. Chronic overuse causes fatigue, dry or peeling skin, hair loss, and brittle nails. In very high doses, it can cause brain swelling, liver damage, and serious neurological symptoms — young children are at higher risk from a single large dose.
Are there any side effects from lutein or zeaxanthin at normal doses?
Lutein at typical supplement doses and up to 20 mg daily has not caused adverse effects in trials. Zeaxanthin is generally well-tolerated at typical supplement amounts. Neither has documented side effects at recommended use.
I'm on a blood thinner — is this safe?
High-dose vitamin A can theoretically increase bleeding risk when combined with blood thinners like warfarin. Check with your doctor or pharmacist about whether this product's dose is safe for you and whether you need any monitoring.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Advanced Carotenoid Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Advanced Carotenoid Complex label
Go deeper

The Full Monographs Behind Natural Advanced Carotenoid Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Natural Advanced Carotenoid Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin A 31 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Griffiths JK. The vitamin A paradox. J Pediatr 2000;137:604-7.. PubMed
  3. Hardman JG, Limbird LL, Molinoff PB, eds. Goodman and Gillman's The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill, 1996.
  4. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  5. FDA Talk Paper. Vitamin A and birth defects (T95-56). Food and Drug Administration, U.S. Department of Health and Human Services, Rockville, MD. October 6, 1995.
  6. Russell RM. The vitamin A spectrum: from deficiency to toxicity. Am J Clin Nutr 2000;71:878-84. PubMed
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Feskanich D, Singh V, Willett WC, Colditz GA. Vitamin A intake and hip fractures among postmenopausal women. JAMA 2002;287:47-54. PubMed
  9. Melhus H, Michaelsson K, Kindmark A, et al. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann Intern Med 1998;129:770-8. PubMed
  10. Michaelsson K, Lithell H, Vessby B, Melhus H. Serum retinol levels and the risk of fracture. N Engl J Med 2003;348:287-94.. PubMed
  11. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. DOI
  12. Meyskens FL Jr, Graham V, Chvapil M, et al. A phase I trial of beta-all-trans-retinoic acid delivered via a collagen sponge and a cervical cap for mild or moderate intraepithelial cervical neoplasia. J Natl Cancer Inst 1983;71:921-5..
  13. Hathcock JN, Hattan DG, Jenkins MY, et al. Evaluation of vitamin A toxicity. Am J Clin Nutr 1990;52:183-202.. PubMed
  14. Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. Br Med J 1981;282:19-20.. PubMed
  15. Pearson MG, Littlewood SM, Bowden AN. Tetracycline and benign intracranial hypertension (letter). Br Med J 1981;282:568-9.. PubMed
  16. Azais-Braesco V, Pascal G. Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 2000;71:1325S-33S. PubMed
  17. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  18. Grotto, I., Mimouni, M., Gdalevich, M., and Mimouni, D. Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis. J Pediatr 2003;142(3):297-304. PubMed
  19. Mahalanabis, D., Lahiri, M., Paul, D., Gupta, S., Gupta, A., Wahed, M. A., and Khaled, M. A. Randomized, double-blind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute l
  20. Long, K. Z., Montoya, Y., Hertzmark, E., Santos, J. I., and Rosado, J. L. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mex
  21. Fritz, H., Kennedy, D., Fergusson, D., Fernandes, R., Doucette, S., Cooley, K., Seely, A., Sagar, S., Wong, R., and Seely, D. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS.One. 2011;6(6):e21107. PubMed
  22. Mayo-Wilson, E., Imdad, A., Herzer, K., Yakoob, M. Y., and Bhutta, Z. A. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094. PubMed
  23. Mazumder S, Taneja S, Bhatia K, Yoshida S, Kaur J, Dube B, Toteja GS, Bahl R, Fontaine O, Martines J, Bhandari N; Neovita India Study Group. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovit
  24. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102(6):556-8. PubMed
  25. Darlow BA, Graham PJ, Rojas-Reyes MX. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants. Cochrane Database Syst Rev. 2016;(8):CD000501. PubMed
  26. Haider BA, Sharma R, Bhutta ZA. Neonatal vitamin A supplementation for the prevention of mortality and morbidity in term neonates in low and middle income countries. Cochrane Database Syst Rev. 2017;2:CD006980. PubMed
  27. Mohammad YM, Raslan IR, Al-Hussain FA. Idiopathic Intracranial Hypertension Induced by Topical Application of Vitamin A. J Neuroophthalmol. 2016;36(4):412-3. PubMed
  28. Masnadi Shirazi K, Nikniaz Z, Masnadi Shirazi A, Rohani M. Vitamin A supplementation decreases disease activity index in patients with ulcerative colitis: A randomized controlled clinical trial. Complement Ther Med. 2018 Dec;41:215-219. PubMed
  29. Ding Y, Hu P, Yang Y, et al. Impact of maternal daily oral low-dose vitamin A supplementation on the mother-infant pair: a randomised placebo-controlled trial in China. Nutrients 2021;13(7):2370. PubMed
  30. Knapik JJ, Hoedebecke SS. Vitamin A and bone fractures: systematic review and meta-analysis. J Spec Oper Med 2021;21(2):100-7. PubMed
  31. Imdad A, Mayo-Wilson E, Haykal MR, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age. Cochrane Database Syst Rev 2022;3(3):CD008524. PubMed

See these in context on the Vitamin A monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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