Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Gut Buddies Ingredients & Drug Interactions

by Tishcon Corp.

Gut Buddies label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Buddies against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Buddies is a dietary supplement by Tishcon Corp. with 3 active ingredients. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum, Lactobacillus helveticus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gut Buddies by Tishcon Corp.

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Buddies by Tishcon Corp. — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut Buddies by Tishcon Corp.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Blend” is a proprietary blend — the label gives one combined amount (2,000,000,000 CFU) without saying how much of each component you get.

Gut Buddies contains three active probiotic ingredients: Bifidobacterium longum and Lactobacillus helveticus (both live bacteria meant to support your digestive health) and Lactobacillus rhamnosis. The product also contains several inactive ingredients — the capsule material (hypromellose), fillers, and stabilizers like ascorbic acid and silicon dioxide — but the active components are the three bacterial strains.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive health and regularity support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Diarrhea, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Ulcerative colitis, Irritable bowel syndrome (IBS), and more.

The evidence for these probiotics isn't established in the data we hold. Bifidobacterium longum and Lactobacillus helveticus have both been studied for conditions like antibiotic-associated diarrhea, allergic rhinitis, and cognitive function, but the research so far shows insufficient reliable evidence to rate them for any of those uses.

That doesn't mean they don't work — it means we don't yet have solid proof they do. Talk with your doctor about whether this product makes sense for what you're hoping to treat.

The evidence, ingredient by ingredient Bifidobacterium Longum Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy people, but caution is advised if you're seriously ill or have a weakened immune system — check with your doctor first. Rare side effects reported include abdominal discomfort, flatulence, constipation, and one case of a dry cough.

There have been very rare cases of the bacteria themselves causing serious infections (bacteremia or sepsis) in critically ill infants and compromised patients, so this product isn't appropriate for everyone. Limited safety data exist for breastfeeding, so talk with your doctor if you're nursing.

Side effects, ingredient by ingredient Bifidobacterium Longum Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Longum, Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main medication type to double-check is antibiotic drugs — they may reduce how well these probiotics work, so you'll want to separate the timing. Use the medication checker below to review your exact prescriptions before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gut Buddies is a three-strain probiotic designed to support digestive health. It's generally well tolerated in healthy people, but if you're on antibiotics, you'll need to space out when you take it.

If you're seriously ill, immunocompromised, or pregnant/breastfeeding, check with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Buddies, straight from the product label.

Brand Tishcon Corp.
Barcode (UPC) 614654347079
Net contents 90 Vege Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2015
DSLD ID 46383
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Buddies by Tishcon Corp., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vege Capsule(s)
Maximum serving Sizes:
1 Vege Capsule(s)
Servings per container
90
UPC/BARCODE
614654347079
IngredientAmount% DV
Blend2000000000 CFU--
Bifidobacterium longum0 NP--
Lactobacillus rhamnosis0 NP--
Lactobacillus helveticus0 NP--

Other ingredients: Hypromellose, Maltodextrin, Vegetable Lipids, Magnesium Stearate, Silicon Dioxide, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

KEEP OUT OF THE REACH OF CHILDREN.

If you are pregnant or nursing a baby, seek the advice of a health professional before using this product.

TAMPER EVIDENT - DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING.

Contains soy.

Storage

Room temperature stable. Does not require refrigeration.

Keep bottle tightly closed. Store in a cool, dry place between 15(0)-30(0)C (59(0)-86(0)F).

Brand IP Statement(s)

ME: Microencapsulated by the Probiocap(R) Process. Probiocap(R) is a registered trademark of Institut Rosell. Gut Buddies(R) and Probiotics For The New Millenium(R) are registered trademarks of Tishcon Corp.

Probiotics For The New Millennium(R)

Guaranteed Two Billion Viable Gut Buddies(R) per Vege-capsule

Microencapsulation ensures bacterial survival until they reach the intestine. The proprietary technology "Probiocap(R)" protects the bacteria from stomach acids.

General Statements

Made in the U.S.A.

Seals/Symbols

TECHNOLOGY INSTITUTE ROSELL probiocap(R)

FDA Statement of Identity

Dietary Supplement

Formula

Contains soy.

Formulation

Free of: milk and milk by-products, egg and egg by-products, fish and fish by-products, shellfish and shellfish by-products, tree nuts, wheat and wheat by-products, peanuts and peanut by-products.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) vege-capsule daily with a meal, as a dietary supplement

FDA Disclaimer Statement

THE INFORMATION ON THIS LABEL HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

General

11296C R0215

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Buddies by Tishcon Corp. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Buddies label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Buddies by Tishcon Corp.

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vege Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Blend

2000000000 CFU per serving

Other (inactive) ingredients: Hypromellose, Maltodextrin, Vegetable Lipids, Magnesium Stearate, Silicon Dioxide, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Buddies by Tishcon Corp. Drug Interactions

Want to check YOUR meds against Gut Buddies?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum 182
Lactobacillus helveticus 182

Individual Drug Interactions

The ingredients in Gut Buddies interact with 182 drugs. Click any drug to see the details.

2 of the 3 ingredients in Gut Buddies interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum Lactobacillus helveticus

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Buddies with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Lactobacillus helveticus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus helveticus with antibiotic drugs might decrease the effectiveness of L. helveticus.
Lactobacillus helveticus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. helveticus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus helveticus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Buddies, from the product label.

Tishcon Corp.

See all Tishcon Corp. products
Phone Number
1-800-848-8442
Pharmacist Counseling Corner

Gut Buddies by Tishcon Corp.: Common Questions

Does Gut Buddies by Tishcon Corp. interact with any medications?
Yes. Based on its ingredients, Gut Buddies has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Buddies contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Gut Buddies while I'm on an antibiotic?
You can take both, but not at the same time. Antibiotics kill the live bacteria in this product, so they'll be less effective if taken together. Ask your pharmacist how far apart to space them — usually a few hours is enough.
Is this safe if I'm pregnant or breastfeeding?
Bifidobacterium longum is rated Possibly Safe in pregnancy and lactation. For Lactobacillus helveticus, we don't have safety data on file for pregnancy or breastfeeding, and Lactobacillus rhamnosis data isn't available to us. Talk with your doctor or pharmacist for personalized advice based on your situation.
What are the side effects?
Most people tolerate it well. Rare side effects include abdominal discomfort, flatulence, constipation, and in very rare cases, a dry cough. If you're seriously ill or have a weak immune system, there's a small risk of infection from the bacteria themselves, so talk with your doctor first.
Do these probiotics actually work?
The research we have doesn't yet show they're effective for the conditions they've been studied for — like antibiotic-associated diarrhea or hay fever. That doesn't mean they won't help you, just that we don't have solid proof yet. Ask your doctor if it's worth trying.
Should I avoid this if I'm immune-compromised?
Yes, talk with your doctor first. While serious infections are very rare, people who are seriously ill or have weakened immune systems are at higher risk and need medical guidance before using a live probiotic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gut Buddies is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Buddies label
Go deeper

The Full Monographs Behind Gut Buddies’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Gut Buddies's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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