Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Gut Buddies Supreme Ingredients & Drug Interactions

by Tishcon Corp.

Gut Buddies Supreme label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Buddies Supreme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Buddies Supreme is a dietary supplement by Tishcon Corp. with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are La-14 Lactobacillus acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gut Buddies Supreme by Tishcon Corp.

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Buddies Supreme by Tishcon Corp. — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut Buddies Supreme by Tishcon Corp.

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Bacteria Blend” is a proprietary blend — the label gives one combined amount (60,000,000,000 CFU) without saying how much of each component you get.

Gut Buddies Supreme contains five active bacterial strains. The only one we have detailed information on is La-14 Lactobacillus acidophilus, a probiotic organism that supports gut health.

The other four — Lactobacillus salivarius, Lactobacillus plantarum, Lactobacillus casei, and Bifidobacterium lactis — are also included in the blend but detailed profiles aren't available in our data. The capsule also contains inactive ingredients: microcrystalline cellulose, hypromellose, vegetable magnesium stearate, silicon dioxide, and purified water.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Broad spectrum digestive health probiotic support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Helicobacter pylori — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence is weaker for atopic disease (possibly ineffective), and we don't have enough reliable data to rate it for acute respiratory distress syndrome (ARDS).

Effectiveness for the other four bacterial strains in this blend isn't established in the data we hold.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects — including belly discomfort, pain, indigestion, gas, bloating, diarrhea, vomiting, and burping — can occur when you combine it with other probiotics, but these are uncommon.

Because L. acidophilus is a live organism, there's a theoretical risk of infection in certain patients; cases of bacteremia, sepsis, and abscess have been documented, though most are thought to involve bacteria that naturally live in the body. Check with your doctor before use, especially if you have a compromised immune system or are hospitalized.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before combining Gut Buddies Supreme with antibiotic drugs (Moderate severity). Antibiotics can kill off the live bacteria in this product and reduce its effectiveness.

Additionally, we weren't able to check for interactions with the other four bacterial strains, so run your full medication list through the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Gut Buddies Supreme is a multi-strain probiotic best considered if you have IBS, antibiotic-associated diarrhea, or related conditions where L. acidophilus shows promise. If you take antibiotics, separate them from this supplement by a few hours to protect the live organisms.

Talk to your pharmacist before starting, particularly if you're on any medications or have immune concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Buddies Supreme, straight from the product label.

Brand Tishcon Corp.
Barcode (UPC) 614654942021
Net contents 30 Vege Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2015
DSLD ID 46595
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Buddies Supreme by Tishcon Corp., sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vege Capsule(s)
Maximum serving Sizes:
1 Vege Capsule(s)
Servings per container
30
UPC/BARCODE
614654942021
IngredientAmount% DV
Bacteria Blend60000000000 CFU--
La-14 Lactobacillus acidophilus0 NP--
Ls-33 Lactobacillus salivarius0 NP--
Lp-115 Lactobacillus plantarum0 NP--
Lc-11 Lactobacillus casei0 NP--
Bi-04 Bifidobacterium lactis0 NP--

Other ingredients: low mositure Microcrystalline Cellulose, Hypromellose, Vegetable Magnesium Stearate, Silicon Dioxide, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Guaranteed 60 Billion Viable cfu per Vege-capsule

Broad Spectrum Probiotic

STOP PEELING

The special probiotic cultures in this product ensure viable cfu through the expiration date.

PEEL HERE FOR MORE INFOORMATION

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: Take one (1) Vege-capsule once daily with a meal, as a dietary supplement.

Formulation

Free of egg or egg by-products, fish or fish by-products, shellfish or shellfish by-products, tree nuts, wheat or wheat by-products, peanut or peanut by-products and soybeans and soy by-products.

Precautions

Caution: Before using any dietary supplement, pregnant or lactating women should consult a physician or health professional.

KEEP OUT OF REACH OF CHILDREN.

TAMPER RESISTANT-DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING.

FDA Disclaimer Statement

THE INFORMATION ON THIS LABEL HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT CURE OR PREVENT ANY DISEASE.

Storage

To preserve quality and freshness, keep bottle tightly closed. Store in a cool, dry place. Room temperature stable.

Brand IP Statement(s)

Gut Buddies(R) is a registered trademark of Tishcon Corp.

General

10998C N1111

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Buddies Supreme by Tishcon Corp. label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Buddies Supreme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Buddies Supreme by Tishcon Corp.

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vege Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bacteria Blend

60000000000 CFU per serving
  • › La-14 Lactobacillus acidophilus
  • › Ls-33 Lactobacillus salivarius
  • › Lp-115 Lactobacillus plantarum
  • › Lc-11 Lactobacillus casei
  • › Bi-04 Bifidobacterium lactis

Other (inactive) ingredients: Low mositure Microcrystalline Cellulose, Hypromellose, Vegetable Magnesium Stearate, Silicon Dioxide, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Buddies Supreme by Tishcon Corp. Drug Interactions

Want to check YOUR meds against Gut Buddies Supreme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

La-14 Lactobacillus acidophilus 182

Individual Drug Interactions

The ingredients in Gut Buddies Supreme interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in Gut Buddies Supreme interact with drugs. Each result below shows which ingredient is responsible. La-14 Lactobacillus acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Buddies Supreme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

La-14 Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
La-14 Lactobacillus acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Buddies Supreme, from the product label.

Tishcon Corp.

See all Tishcon Corp. products
Phone Number
1-800-848-8442
Pharmacist Counseling Corner

Gut Buddies Supreme by Tishcon Corp.: Common Questions

Does Gut Buddies Supreme by Tishcon Corp. interact with any medications?
Yes. Based on its ingredients, Gut Buddies Supreme has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Buddies Supreme contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Should I take this at the same time as my antibiotic?
No — separate them by a few hours if you can. Antibiotics can kill the live organisms in this probiotic and make it less effective. Your pharmacist can suggest the best timing for your specific antibiotic.
What does Lactobacillus acidophilus actually do?
It's a beneficial bacterium that supports gut health. The evidence is strongest for irritable bowel syndrome, antibiotic-associated diarrhea, Helicobacter pylori infection, and bacterial vaginosis, where it's rated possibly effective.
Can this cause side effects?
Most people tolerate it well, but some experience mild gastrointestinal symptoms like gas, bloating, or indigestion — these are uncommon. Very rarely, live probiotic bacteria can cause infection in people with weakened immune systems, so check with your doctor if that applies to you.
What are the other bacterial strains in this blend?
The product contains Lactobacillus salivarius, Lactobacillus plantarum, Lactobacillus casei, and Bifidobacterium lactis alongside the L. acidophilus. We don't have detailed effectiveness or interaction data on file for those four strains.
Is there anything else in this capsule besides the probiotics?
Yes — the capsule also contains microcrystalline cellulose, hypromellose, vegetable magnesium stearate, silicon dioxide, and purified water as inactive ingredients.
How do I know if this will work for me?
Lactobacillus acidophilus shows promise for IBS, antibiotic-associated diarrhea, and certain infections, but the evidence is still limited. If you have one of those conditions, talk with your doctor about whether a probiotic trial makes sense for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gut Buddies Supreme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Buddies Supreme label
Go deeper

The Full Monographs Behind Gut Buddies Supreme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Gut Buddies Supreme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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