Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Gut Instinct Ingredients & Drug Interactions

by Reset/360

Gut Instinct label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gut Instinct against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gut Instinct is a dietary supplement by Reset/360 with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus NCFM. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gut Instinct by Reset/360

Ask about any prescription or over-the-counter medication and we check it for interactions with Gut Instinct by Reset/360 — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gut Instinct by Reset/360

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “A 50:50 Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Gut Instinct contains 2 active probiotic ingredients: Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07. These are live, beneficial bacteria meant to support your gut.

The capsule also contains microcrystalline cellulose, magnesium stearate, and silica as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: probiotic support for gastrointestinal and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Common cold, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Constipation, Inflammatory bowel disease (IBD), Lactose intolerance.

Lactobacillus acidophilus has possibly effective evidence for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence is considered possibly ineffective for atopic disease (allergic conditions), and there isn't enough reliable evidence yet to rate it for acute respiratory distress syndrome (ARDS).

The effectiveness of Bifidobacterium lactis Bi-07 is not established in our data.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Since it contains live organisms, there's a small theoretical risk of infection in certain vulnerable patients — most documented cases occurred in people with serious underlying conditions.

Gastrointestinal side effects like bloating, gas, abdominal discomfort, or diarrhea can occur when taking probiotics, though these are uncommon. In pregnancy, Lactobacillus acidophilus is rated possibly safe, though data are limited — talk with your doctor or pharmacist for personalized guidance.

We don't hold safety data for Bifidobacterium lactis Bi-07.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Moderate interaction: separate Gut Instinct from antibiotic drugs by several hours to protect the live bacteria and avoid reducing the probiotic's effectiveness. Check your exact medications with the tool on this page before you start, especially if you're on antibiotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-associated diarrhea, or bacterial vaginosis if you want to try it. The key thing: don't take it at the same time as antibiotics — space them apart.

If you're pregnant, have a weakened immune system, or take any prescription medications, check with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gut Instinct, straight from the product label.

Brand Reset/360
Barcode (UPC) 853387006499
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 249193
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gut Instinct by Reset/360, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
853387006499
IngredientAmount% DV
Lactobacillus acidophilus NCFM0 NP--
Bifidobacterium lactis Bi-070 NP--
A 50:50 Blend0 NP--

Other ingredients: Microcrystalline Cellulose, Capsule, Lactobacillus acidophilus NCFM, Magnesium Stearate, Bifidobacterium lactis Bi-07, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Gut Instinct provides a dairy-free base for a blend of highly viable, pure strains of L. acidophilus NCFM and B. lactis Bi-07 --"friendly" bacteria that have been shown to support a healthy intestinal environment and immune health.

Suggested/Recommended/Usage/Directions

Directions: Take one capsule one to two times daily or as directed by your healthcare practitioner.

Formulation

This product is non-GMO, gluten-free, and vegetarian.

Daily probiotic support for gastrointestinal & immune health

Vegetarian capsule

This product is non-GMO, gluten-free, and vegetarian.

General Statements

Notice: Stability studies indicate that all probiotics should be shipped under temperature control to maintain potency (CFU).

Formulated for Sara Gottfried M.D.

Storage

For best results, store in a cool dry place or keep refrigerated.

Precautions

Tamper evident: Do not use if safety seal is missing or broken.

FDA Statement of Identity

Probiotic Supplement

Brand IP Statement(s)

NCFM and Bi-07 are registered trademarks licensed by DuPont

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gut Instinct by Reset/360 label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gut Instinct label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gut Instinct by Reset/360

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

A 50:50 Blend

0 NP per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule, Lactobacillus acidophilus NCFM, Magnesium Stearate, Bifidobacterium lactis Bi-07, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gut Instinct by Reset/360 Drug Interactions

Want to check YOUR meds against Gut Instinct?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus NCFM 182

Individual Drug Interactions

The ingredients in Gut Instinct interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in Gut Instinct interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus NCFM

Each ingredient & the kinds of drugs it affects

For each ingredient in Gut Instinct with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus NCFM1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus NCFM full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gut Instinct, from the product label.

Reset/360

See all Reset/360 products
Name
Gottfried Institute
Street Address
1480C Moraga Road, #366
City
Moraga
State
CA
ZipCode
94556
Phone Number
866-649-4334
Pharmacist Counseling Corner

Gut Instinct by Reset/360: Common Questions

Does Gut Instinct by Reset/360 interact with any medications?
Yes. Based on its ingredients, Gut Instinct has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gut Instinct contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the same time. Antibiotics kill the live organisms in this product, which defeats the purpose. Ask your doctor or pharmacist how many hours you should wait between taking your antibiotic and this probiotic — spacing them out is usually the answer.
What's the difference between these two bacteria?
Both Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 are beneficial gut bacteria, but they work in slightly different parts of your digestive system and may support different functions. The blend gives you both.
Is this safe in pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, though data are limited. Talk with your doctor or pharmacist for personalized advice — they know your full health picture and can help you decide whether it makes sense for you.
Can it cause gas or bloating?
Yes, probiotics can cause gastrointestinal side effects like gas, bloating, or stomach discomfort, but this is uncommon. If you do experience these, they often settle down as your gut adjusts.
Will this help my IBS?
Lactobacillus acidophilus is considered possibly effective for IBS, which means the evidence suggests it may help — but the research isn't conclusive yet. Your individual results may vary, and it's worth discussing with your doctor whether it's right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gut Instinct label
Go deeper

The Full Monographs Behind Gut Instinct’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Gut Instinct's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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