Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Gynostemma 500 mg Ingredients & Drug Interactions

by Ron Teeguarden's Dragon Herbs

Gynostemma 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gynostemma 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gynostemma 500 mg is a dietary supplement by Ron Teeguarden's Dragon Herbs with 1 active ingredient. Its ingredients are commonly taken for fatigue and stress (adaptogen), blood sugar support, high blood pressure.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gynostemma pentaphyllum Leaf Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Gynostemma pentaphyllum leaf extract (jiaogulan), a traditional herbal ingredient supplied in powdered form at 500 mg per capsule. The remaining ingredients are inactive plant-based materials—pullulan polysaccharide (derived from plant fermentation), rice powder, bamboo extract powder, and rice extract blend—that serve as the capsule matrix and filler.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: adaptogenic herb for stress and wellness.
  • We looked for evidence on: Stress, fatigue, immune function, general resilience.
  • The closest evidence on file: Jiaogulan is rated "Insufficient Reliable Evidence To Rate" for Stress (Natural Medicines).

Jiaogulan is possibly effective for diabetes based on clinical research showing it can lower blood glucose levels. For athletic performance, cancer, cardiovascular disease, nonalcoholic fatty liver disease, and respiratory tract infections, the evidence in our data is insufficient to rate its effectiveness—we simply don't have enough reliable study data to make a claim either way.

The evidence, ingredient by ingredient Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jiaogulan is generally well tolerated in short-term use (up to 4 months), though long-term safety hasn't been well studied. The most common side effects reported are diarrhea and nausea; dry mouth, dizziness, and insomnia have also been noted.

Because safety hasn't been established in pregnancy, the data advises against use during pregnancy. Similarly, there isn't enough safety information to recommend it while breastfeeding—talk with your doctor or pharmacist about whether it's right for you in either situation.

Side effects, ingredient by ingredient Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Jiaogulan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your own doctor or pharmacist if you're on any blood thinners or antiplatelet drugs (like warfarin or aspirin)—jiaogulan may increase bleeding risk. Also confirm if you take immunosuppressive medications or diabetes drugs, since jiaogulan might interfere with how well they work or raise your low blood sugar risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Jiaogulan may be worth considering if you're looking for support with blood sugar management and you don't take blood thinners, immunosuppressive drugs, or diabetes medications. If you do take any of those, you'll want to check with your own doctor or pharmacist first.

Pregnant and breastfeeding people should avoid it until safety is better established. It's generally well tolerated for short-term use, but long-term effects aren't clear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gynostemma 500 mg, straight from the product label.

Brand Ron Teeguarden's Dragon Herbs
Barcode (UPC) 679372005342
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 279151
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
33
UPC/BARCODE
679372005342
IngredientAmount% DV
Gynostemma pentaphyllum Leaf Extract, Powder1500 mg--

Other ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Gynostemma is often referred to as "Ginseng at Tea Price" because it contains over 100 saponins (Gypenosides) that are very similar to Ginseng saponins (Ginseng's active ingredients). Gynostemma is a quintessential adaptogenic herb. Prolonged consumption of Gynostemma strengthens the adaptive capacity of the person at every level of their life. Gynostemma has a double-direction regulating effect/activity in many areas.

Gynostemma 500 mg per capsule

Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.

Seals/Symbols

Di Tao Certified Authentic Source

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 3 capsules, 2 times per day or as directed by a health care professional.

Formulation

Pullulan caps - 100% natural, water-soluble polysaccharide produced through a fermentation process; vegetable origin; non-GMO; no starch, preservatives or chemical modifications; gluten free.

Precautions

Keep out of the reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gynostemma 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container33 Amounts shown are per serving.

Gynostemma pentaphyllum Leaf Extract, Powder

Interacts with
327 drugs
1500 mg per serving

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Gynostemma pentaphyllum Leaf Extract, Powder monograph & interactions

Other (inactive) ingredients: Pullulan Polysaccharide, Rice, Powder, Bamboo Extract, Powder, Rice extract Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs Drug Interactions

Want to check YOUR meds against Gynostemma 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Gynostemma pentaphyllum Leaf Extract, Powder 327

Individual Drug Interactions

The ingredients in Gynostemma 500 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gynostemma 500 mg interact with drugs. Each result below shows which ingredient is responsible. Gynostemma pentaphyllum Leaf Extract, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Gynostemma 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gynostemma pentaphyllum Leaf Extract, Powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Gynostemma pentaphyllum Leaf Extract, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gynostemma 500 mg, from the product label.

Ron Teeguarden's Dragon Herbs

See all Ron Teeguarden's Dragon Herbs products
Name
Ron Teeguarden's Dragon Herbs
Street Address
P.O. Box 361459
City
Los Angeles
State
CA
ZipCode
90036
Phone Number
(888) 558-6642
Web Address
www.dragonherbs.com
Pharmacist Counseling Corner

Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs: Common Questions

Does Gynostemma 500 mg by Ron Teeguarden's Dragon Herbs interact with any medications?
Yes. Based on its ingredients, Gynostemma 500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gynostemma 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Safety data advises against jiaogulan during pregnancy because effects on the developing baby haven't been established. There's also not enough safety information for breastfeeding. Talk with your doctor or pharmacist about your options.
What are the side effects?
Diarrhea and nausea are the most commonly reported. Dry mouth, dizziness, and insomnia have also been noted. These happened in people using jiaogulan for up to 4 months; long-term effects aren't well studied.
Is jiaogulan proven to help with diabetes?
Clinical research shows it's possibly effective for diabetes—studies demonstrate it can lower blood glucose levels. However, that's not a substitute for prescription diabetes medication. Talk with your doctor about how it fits into your overall plan.
Does it help with athletic performance or other conditions?
The evidence we have isn't strong enough to rate jiaogulan for athletic performance, cancer, heart disease, fatty liver disease, or respiratory infections. There's simply not enough reliable research data to say whether it works for those.
How long is it safe to take this?
Jiaogulan appears well tolerated for up to 4 months, but long-term safety over months or years hasn't been well studied. If you're thinking of using it long-term, talk with your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gynostemma 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gynostemma 500 mg label
Go deeper

The Full Monographs Behind Gynostemma 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

Gynostemma 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Jiaogulan 8 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

See these in context on the Jiaogulan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team