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Dietary supplement

Gynostemma Extract 250 mg Veg Capsules Ingredients & Drug Interactions

by BulkSupplements.com

Gynostemma Extract 250 mg Veg Capsules label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gynostemma Extract 250 mg Veg Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gynostemma Extract 250 mg Veg Capsules is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for fatigue and stress (adaptogen), blood sugar support, high blood pressure.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gynostemma Leaf, Stem Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Gynostemma Leaf, Stem Extract (jiaogulan), a traditional herbal extract with a long history in Asian medicine. Each capsule provides 250 mg of it.

The capsule shell is made from hypromellose, a plant-based material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Jiaogulan's overall clinical evidence instead.

Moderate

Some clinical evidence supports Jiaogulan for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).

Jiaogulan is rated possibly effective for type 2 diabetes based on clinical research showing it can lower blood glucose levels. For athletic performance, cancer, heart disease, fatty liver disease, and respiratory infections, the evidence we hold is insufficient to establish whether it works.

If you're interested in this supplement for one of those other uses, talk to your doctor or pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient Jiaogulan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Jiaogulan appears generally well tolerated when used as a tea or supplement for up to about four months. The most common side effects are diarrhea and nausea; some people also report dry mouth, dizziness, or trouble sleeping.

Long-term safety beyond a few months hasn't been well studied. Do not use this supplement during pregnancy — safety data advises against it because the effects on a developing baby are unknown.

Avoid it while breastfeeding as well, since there isn't enough information to know whether it's safe for a nursing infant. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering any supplement.

Side effects, ingredient by ingredient Jiaogulan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Jiaogulan.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), immunosuppressants, or diabetes medications. Jiaogulan may increase bleeding risk, interfere with immune-suppressing therapy, or lower blood sugar unpredictably when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Gynostemma might be worth considering if you have type 2 diabetes and want to explore plant-based options — but only after checking with your doctor. Be especially cautious if you take blood thinners, immunosuppressants, or diabetes medications; those interactions are real.

Long-term use hasn't been studied much, so this works best as a short-term option. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gynostemma Extract 250 mg Veg Capsules, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X003L0JSMD
Net contents 180 Veg Capsule(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 312904
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
1 Veg Capsule(s)
Servings per container
180
UPC/BARCODE
X003L0JSMD
IngredientAmount% DV
Gynostemma Leaf, Stem Extract250 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Gynostemma Extract 250 mg per serving

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 capsule once daily, or as directed by a physician.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Storage

Store in a dry, cool place

General Statements

New Scan me

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gynostemma Extract 250 mg Veg Capsules label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Gynostemma Leaf, Stem Extract

Interacts with
327 drugs
250 mg per serving Form: Gynostemma pentaphyllum Leaf Extract, Gynostemma pentaphyllum Stem Extract

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and...

Gynostemma Leaf, Stem Extract monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Gynostemma Extract 250 mg Veg Capsules?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Gynostemma Leaf, Stem Extract 327

Individual Drug Interactions

The ingredients in Gynostemma Extract 250 mg Veg Capsules interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Gynostemma Extract 250 mg Veg Capsules interact with drugs. Each result below shows which ingredient is responsible. Gynostemma Leaf, Stem Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Gynostemma Extract 250 mg Veg Capsules with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gynostemma Leaf, Stem Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, jiaogulan might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research suggests that jiaogulan has antiplatelet effects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, jiaogulan might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that jiaogulan can lower blood glucose levels.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.
Clinical and animal studies suggest that jiaogulan can stimulate the immune system.

Likelihood Possible Evidence D
Gynostemma Leaf, Stem Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gynostemma Extract 250 mg Veg Capsules, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com: Common Questions

Does Gynostemma Extract 250 mg Veg Capsules by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Gynostemma Extract 250 mg Veg Capsules has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gynostemma Extract 250 mg Veg Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is jiaogulan?
Jiaogulan is a plant extract traditionally used in herbal medicine. In this product, you're getting the leaf and stem extract at 250 mg per capsule.
Does it really help with blood sugar?
Clinical research shows jiaogulan can lower blood glucose levels, so it's rated possibly effective for diabetes. That said, if you have diabetes and take medication, you'll need to talk with your doctor or pharmacist before adding it — the blood sugar–lowering effect could combine with your medication and drop your blood sugar too low.
What are the most common side effects?
Diarrhea and nausea are the main ones reported. Some people also experience dry mouth, dizziness, or insomnia. These seem mild, but stop use and call your pharmacist if they bother you or don't ease up.
Can I take this if I'm pregnant or breastfeeding?
No — safety data advises against use in pregnancy because effects on a developing baby are unknown. The same applies to breastfeeding. If you're pregnant, nursing, or planning to become pregnant, talk to your doctor or pharmacist before taking any supplement.
Is it safe to use long-term?
Short-term use — up to about four months — appears well tolerated. Long-term safety beyond that hasn't been well studied, so this supplement works best as a temporary option, not a lifelong daily habit.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gynostemma Extract 250 mg Veg Capsules is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gynostemma Extract 250 mg Veg Capsules label
Go deeper

The Full Monographs Behind Gynostemma Extract 250 mg Veg Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Jiaogulan

Interacts with 327 drugs

Jiaogulan is a climbing vine used in traditional Chinese medicine as an adaptogen and for heart, blood sugar, and cholesterol support. Early human and animal studies are promising for some u...

Read the full Jiaogulan monograph →
Sources

Sources & How We Checked

Gynostemma Extract 250 mg Veg Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Jiaogulan 8 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80.
  3. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
  4. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383.
  5. Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. PubMed
  6. Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313.
  7. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7.
  8. Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021.

See these in context on the Jiaogulan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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