Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Hemp Seed Oil Ingredients & Drug Interactions

by Nature's Craft

Hemp Seed Oil label
See full label image
Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hemp Seed Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hemp Seed Oil is a dietary supplement by Nature's Craft with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 1,020 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hemp Seed Oil by Nature's Craft

Ask about any prescription or over-the-counter medication and we check it for interactions with Hemp Seed Oil by Nature's Craft — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hemp Seed Oil by Nature's Craft

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Hemp Seed Oil” is listed as a grouped ingredient — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This product contains 5 active ingredients: stearic acid, oleic acid, palmitic acid, alpha-linolenic acid, and linoleic acid — all naturally occurring fatty acids from hemp seed oil. The product also contains inactive ingredients (cellulose, orange oil, and silicon dioxide) as capsule material and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Oleic Acid's overall clinical evidence instead.

Moderate

Some clinical evidence supports Oleic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Possibly Effective" (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

Oleic acid, one of the active ingredients in this product, is possibly effective for high cholesterol and coronary heart disease based on the evidence we hold. The other active ingredients — stearic acid, palmitic acid, alpha-linolenic acid, and linoleic acid — don't have effectiveness ratings in our data.

The evidence, ingredient by ingredient Hemp Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic acid is generally recognized as safe when consumed in normal amounts from foods like olive oil. However, concentrated supplement doses haven't been well studied, so there isn't enough data to know whether supplement-level amounts are safe during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing. No serious adverse effects were reported in the data we hold.

Side effects, ingredient by ingredient Hemp Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drugs (blood sugar medications), check with your doctor or pharmacist before starting this product — oleic acid may increase how well these medications work, potentially lowering your blood sugar more than intended.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you're looking to support cholesterol or heart health and you don't take antidiabetes medications, this product may be worth considering. If you take any blood sugar medication, check with your doctor or pharmacist first — oleic acid in this product could intensify its effects.

Either way, it's worth a quick conversation with your healthcare provider to make sure it fits your personal situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hemp Seed Oil, straight from the product label.

Brand Nature's Craft
Net contents 60 Liquid Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296668
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hemp Seed Oil by Nature's Craft, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Liquid Capsule(s)
Maximum serving Sizes:
2 Liquid Capsule(s)
Servings per container
30
IngredientAmount% DV
Total Fat1 Gram(s)2%
Calories10 Calorie(s)--
Stearic Acid0 NP--
Calories from Fat10 Calories--
Oleic Acid0 NP--
Palmitic Acid0 NP--
Alpha-Linolenic Acid0 NP--
Linoleic Acid0 NP--
Hemp Seed Oil1000 mg--

Other ingredients: Cellulose, Orange Oil, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 2 liquid capsules daily preferably with meals or as directed by a healthcare professional.

Precautions

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Caution: do not exceed recommended dose.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

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New look same craft

Please recycle.

Formulation

Vegan formula

Heart support

Non GMO

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in the USA with global ingredients Sourced from a GMP certified facility Made in an FDA inspected facility 3rd party lab verified

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hemp Seed Oil by Nature's Craft label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hemp Seed Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hemp Seed Oil by Nature's Craft

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Liquid Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Hemp Seed Oil

Interacts with
940 drugs
1000 mg per serving

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...

Hemp Seed Oil monograph & interactions
  • › Stearic Acid
  • › Oleic Acid
  • › Palmitic Acid
  • › Alpha-Linolenic Acid
  • › Linoleic Acid

Other (inactive) ingredients: Cellulose, Orange Oil, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hemp Seed Oil by Nature's Craft Drug Interactions

Want to check YOUR meds against Hemp Seed Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,020Drugs
127 Moderate 893 Minor

Ingredients driving the most interactions

Hemp Seed Oil 940

Individual Drug Interactions

The ingredients in Hemp Seed Oil interact with 1,020 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hemp Seed Oil interact with drugs. Each result below shows which ingredient is responsible. Hemp Seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Hemp Seed Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Seed Oil6 drug types · 940 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hemp Seed Oil, from the product label.

Nature's Craft

See all Nature's Craft products
Name
Nature's Craft
City
Pomona
State
NY
ZipCode
10970
Phone Number
408-599-3841
Web Address
shopnaturescraft.com
Pharmacist Counseling Corner

Hemp Seed Oil by Nature's Craft: Common Questions

Does Hemp Seed Oil by Nature's Craft interact with any medications?
Yes. Based on its ingredients, Hemp Seed Oil has a known interaction with 1,020 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hemp Seed Oil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product really help with cholesterol?
Oleic acid, one of the active ingredients, is possibly effective for high cholesterol and coronary heart disease based on the evidence we hold. That said, it's not a guarantee for everyone, so talk with your doctor about whether it makes sense as part of your overall plan.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety data on supplement-level doses of oleic acid during pregnancy or breastfeeding — food amounts are fine, but concentrated supplements haven't been well studied. Talk with your doctor or pharmacist for personalized advice before taking this product.
What are all these fatty acids for?
Stearic acid, oleic acid, palmitic acid, alpha-linolenic acid, and linoleic acid are all naturally occurring fats from hemp seed oil. Oleic acid is the one with documented effectiveness for cholesterol and heart health; the others don't have established roles in our data.
Will this interfere with my blood pressure medication?
We don't have documented interactions between this product and blood pressure medications in our data. That doesn't mean none exist — if you take blood pressure drugs, check your full medication list with your doctor or pharmacist before starting this product.
Are there any fillers or other junk in it?
The inactive ingredients are cellulose, orange oil, and silicon dioxide — used as capsule material and for flavor. These are standard capsule components, not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hemp Seed Oil is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hemp Seed Oil label
Go deeper

The Full Monographs Behind Hemp Seed Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 940 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph → Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Hemp Seed Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 1 reference
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed

See these in context on the Oleic Acid monograph →

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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