Hemp Seed Oil Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Hemp Seed Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Hemp Seed Oil is a dietary supplement by Nature's Craft with 1 active ingredient. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 1,020 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Hemp Seed Oil by Nature's Craft
Ask about any prescription or over-the-counter medication and we check it for interactions with Hemp Seed Oil by Nature's Craft — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Hemp Seed Oil by Nature's Craft
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 5 active ingredients: stearic acid, oleic acid, palmitic acid, alpha-linolenic acid, and linoleic acid — all naturally occurring fatty acids from hemp seed oil. The product also contains inactive ingredients (cellulose, orange oil, and silicon dioxide) as capsule material and flavoring.
Does it work?
Moderate evidence
Oleic acid, one of the active ingredients in this product, is possibly effective for high cholesterol and coronary heart disease based on the evidence we hold. The other active ingredients — stearic acid, palmitic acid, alpha-linolenic acid, and linoleic acid — don't have effectiveness ratings in our data.
How safe is it?
Some data gaps
Oleic acid is generally recognized as safe when consumed in normal amounts from foods like olive oil. However, concentrated supplement doses haven't been well studied, so there isn't enough data to know whether supplement-level amounts are safe during pregnancy or while breastfeeding.
Talk with your doctor or pharmacist before taking this product if you're pregnant or nursing. No serious adverse effects were reported in the data we hold.
Meds to double-check
Moderate interaction found
If you take any antidiabetes drugs (blood sugar medications), check with your doctor or pharmacist before starting this product — oleic acid may increase how well these medications work, potentially lowering your blood sugar more than intended.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.
If you're looking to support cholesterol or heart health and you don't take antidiabetes medications, this product may be worth considering. If you take any blood sugar medication, check with your doctor or pharmacist first — oleic acid in this product could intensify its effects.
Either way, it's worth a quick conversation with your healthcare provider to make sure it fits your personal situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Hemp Seed Oil, straight from the product label.
| Brand | Nature's Craft |
|---|---|
| Net contents | 60 Liquid Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 296668 |
| Product type | Fat/fatty Acid |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Hemp Seed Oil by Nature's Craft, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Total Fat | 1 Gram(s) | 2% |
| Calories | 10 Calorie(s) | -- |
| Stearic Acid | 0 NP | -- |
| Calories from Fat | 10 Calories | -- |
| Oleic Acid | 0 NP | -- |
| Palmitic Acid | 0 NP | -- |
| Alpha-Linolenic Acid | 0 NP | -- |
| Linoleic Acid | 0 NP | -- |
| Hemp Seed Oil | 1000 mg | -- |
Other ingredients: Cellulose, Orange Oil, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: 2 liquid capsules daily preferably with meals or as directed by a healthcare professional.
Precautions
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.
Keep out of the reach of children.
Do not use if safety seal is damaged or missing.
Caution: do not exceed recommended dose.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
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Formulation
Vegan formula
Heart support
Non GMO
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Made in the USA with global ingredients Sourced from a GMP certified facility Made in an FDA inspected facility 3rd party lab verified
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Hemp Seed Oil by Nature's Craft label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Hemp Seed Oil by Nature's Craft
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Liquid Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Hemp Seed Oil
Interacts with940 drugs
Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for...
Hemp Seed Oil monograph & interactions- › Stearic Acid
- › Oleic Acid
- › Palmitic Acid
- › Alpha-Linolenic Acid
- › Linoleic Acid
Other (inactive) ingredients: Cellulose, Orange Oil, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Hemp Seed Oil by Nature's Craft Drug Interactions
HelloPharmacist Interaction Report
Hemp Seed Oil by Nature's Craft contains oleic acid, which has documented interactions with medications.
The most serious concern is with antidiabetes drugs (blood sugar medications) — oleic acid may increase their effects, potentially lowering your blood sugar more than intended.
Read the full breakdown — every affected drug type, severity by severity
The interaction with antidiabetes drugs is rated Moderate severity. Research in people with type 2 diabetes shows that a diet high in oleic acid from olive oil lowered fasting blood glucose compared to a diet high in linoleic acid from sunflower oil.
This means if you're already taking a medication to control blood sugar, adding this supplement could push your levels lower.
We could not check the interactions of stearic acid, palmitic acid, alpha-linolenic acid, or linoleic acid — we don't hold data for them. If you take any antidiabetes medication, run your full list of prescriptions through the interaction checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Hemp Seed Oil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Hemp Seed Oil interact with 1,020 drugs. Click any drug to see the details.
1 of the 1 ingredient in Hemp Seed Oil interact with drugs. Each result below shows which ingredient is responsible. Hemp Seed Oil
ErtugliflozinSteglatro
How Ertugliflozin interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Ertugliflozin, Metformin Hydrochloride interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Seed Oil + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Seed Oil + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Seed Oil + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
Read the full Hemp Seed Oil + Ethinyl Estradiol, Levonogestrel interactionEtonogestrel, Ethinyl EstradiolNuvaRing
How Etonogestrel, Ethinyl Estradiol interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Hemp Seed OilCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Hemp Seed Oil + Etonogestrel, Ethinyl Estradiol interactionExenatideBydureon, Byetta
How Exenatide interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Hemp Seed Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Hemp Seed Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Hemp Seed Oil
Estrogens
Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.
Ace Inhibitors (Aceis)
Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Anticoagulant/Antiplatelet Drugs
Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.
Antihypertensive Drugs
Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Brand information
Manufacturer and brand details for Hemp Seed Oil, from the product label.
Nature's Craft
See all Nature's Craft products- Name
- Nature's Craft
- City
- Pomona
- State
- NY
- ZipCode
- 10970
- Phone Number
- 408-599-3841
- Web Address
- shopnaturescraft.com
Hemp Seed Oil by Nature's Craft: Common Questions
Does Hemp Seed Oil by Nature's Craft interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product really help with cholesterol?
Is it safe to take while pregnant or breastfeeding?
What are all these fatty acids for?
Will this interfere with my blood pressure medication?
Are there any fillers or other junk in it?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Hemp Seed Oil is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Hemp Seed Oil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Hemp
Interacts with 940 drugsHemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...
Read the full Hemp monograph → Herb & supplement monographOleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph →Sources & How We Checked
Hemp Seed Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
- Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
- Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
- Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
- Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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