Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Probiotic Pearls Women's Ingredients & Drug Interactions

by Nature's Way

Probiotic Pearls Women's label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Pearls Women's against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Pearls Women's is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are HOWARU Lactobacillus acidophilus NCFM. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Pearls Women's by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Pearls Women's by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Pearls Women's by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (17 mg) without saying how much of each component you get.

This product contains three active probiotic strains: Lactobacillus rhamnosus LR-32, Lactobacillus plantarum LP-115, and HOWARU Lactobacillus acidophilus NCFM. Probiotics are beneficial live bacteria meant to support digestive and vaginal health.

The softgels also contain inactive ingredients—palm oil, fish gelatin, glycerin, soy lecithin, and pectin—that help deliver and protect the active probiotics.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: vaginal and urinary health support.
  • We looked for evidence on: Bacterial vaginosis, Urinary tract infections (UTIs), Vaginal candidiasis, vulvovaginal health, pelvic health.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs), Vaginal candidiasis.

Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence for acute respiratory distress syndrome isn't strong enough to rate, and it appears possibly ineffective for atopic disease (allergic conditions).

We don't have effectiveness ratings on file for the other two probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Minor gastrointestinal side effects like gas, bloating, abdominal pain, and diarrhea can occur when taking it with other probiotics, but these are uncommon.

Rarely, the live bacteria can cause serious infections in people with weakened immune systems; most documented cases involved bacteria that likely came from elsewhere in the body. Since data are limited, check with your doctor before starting this supplement, especially if you have a compromised immune system or serious illness.

Pregnancy safety is rated as possibly safe, but we don't have enough information on lactation, so talk with your healthcare provider if you're breastfeeding.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main concern—they can kill the live organisms in this probiotic, making it less effective. Time them apart from this supplement, and talk with your pharmacist about the best way to space them.

Since we couldn't check the other two probiotic strains in our data, use the medication checker below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Probiotic Pearls Women's is meant for people looking to support digestive and vaginal health with live beneficial bacteria. If you're on antibiotics, you'll need to separate the timing—ask your pharmacist for the best schedule.

Before you start, run your medications through our checker and confirm with your own doctor or pharmacist that it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Pearls Women's, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948082803
Net contents 10 Softgel(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 270534
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Pearls Women's by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
10
UPC/BARCODE
763948082803
IngredientAmount% DV
Proprietary Probiotic Blend17 mg--
Lactobacillus rhamnosus LR-320 NP--
Lactobacillus plantarum LP-1150 NP--
HOWARU Lactobacillus acidophilus NCFM0 NP--

Other ingredients: Palm Oil, Fish Gelatin, Glycerin, Soy Lecithin, Pectin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Probiotic Pearls are safety sealed in a tamper-evident foil pouch. Do not use if foil or plastic is punctured.

Contains fish (tilapia) and soy

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before using Probiotics Pearls.

Storage

Store at room temperature. Avoid excessive heat and direct sunlight.

Formulation

These products contain no yeast-derived ingredients or dairy.

Woman’s Whole Body Clean triple-action internal cleansing system is a way to keep your digestion in balance. This two-step program combines the dynamic powder of premium oils and goldenseal extract with a unique fiber blend and probiotics to support your body’s digestive balance.

Triple-action internal cleansing system The power of three! 2. Probiotic Pearls Women’s promotes digestive balance and colon health while you cleanse.

Provides probiotics for digestive balance

Suggested/Recommended/Usage/Directions

Day 6-10: Restore & revitalize! Two Probiotic Pearls Women’s probiotic softgels provide superior strains to support vaginal and urinary health. Five Fiber Fusion Daily capsules daily provide a good source of fiber. Note: After completing this cleanse program, you can continue to live comfortably by regularly taking Probiotic Pearls Women’s at a maintenance dose of 1 softgel daily. Probiotic Pearls Women’s is sold in a 30-count size, at fine natural food retailers nationwide.

Recommendation: Days 6-10 only: Take 1 softgel in the morning and 1 at night. May be taken with or without food. Do not chew or crush.

Brand IP Statement(s)

Copyright 2021 Nature’s Way Brands, LLC

Nature’s Way since 1969

HOWARU is a registered trademark of DuPont. HOWARU Probiotic quality you can feel

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Simple 10-day cleanse

Distributed by Nature’s Way Brands, LLC

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Pearls Women's by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Pearls Women's label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Pearls Women's by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container10 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

17 mg per serving

Other (inactive) ingredients: Palm Oil, Fish Gelatin, Glycerin, Soy Lecithin, Pectin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Pearls Women's by Nature's Way Drug Interactions

Want to check YOUR meds against Probiotic Pearls Women's?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

HOWARU Lactobacillus acidophilus NCFM 182

Individual Drug Interactions

The ingredients in Probiotic Pearls Women's interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Probiotic Pearls Women's interact with drugs. Each result below shows which ingredient is responsible. HOWARU Lactobacillus acidophilus NCFM

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Pearls Women's with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

HOWARU Lactobacillus acidophilus NCFM1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
HOWARU Lactobacillus acidophilus NCFM full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Pearls Women's, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
Pharmacist Counseling Corner

Probiotic Pearls Women's by Nature's Way: Common Questions

Does Probiotic Pearls Women's by Nature's Way interact with any medications?
Yes. Based on its ingredients, Probiotic Pearls Women's has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Pearls Women's contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Antibiotics can kill the live bacteria in this probiotic, so it may not work as well. You'll want to separate them—take the antibiotic and the probiotic at different times of day. Ask your pharmacist for the best timing for your specific antibiotic.
Does Lactobacillus acidophilus really help with IBS or yeast infections?
The evidence says it's possibly effective for irritable bowel syndrome and bacterial vaginosis. That means some research supports it, but we don't have rock-solid proof yet. Results vary from person to person.
What are the side effects?
Most people tolerate it well. Gas, bloating, and stomach discomfort can happen, especially when combined with other probiotics, but these are uncommon. Serious infections are very rare and mainly occur in people with weakened immune systems.
Is it safe to take while pregnant?
Lactobacillus acidophilus is rated as possibly safe in pregnancy, but we don't have enough safety data to be certain. Talk with your doctor about whether it's right for you during pregnancy.
What's in the capsule besides the probiotics?
The softgel contains palm oil, fish gelatin, glycerin, soy lecithin, and pectin—these are inactive ingredients that protect and deliver the live bacteria. If you have allergies to any of these, check the label.
Will this help if I have atopic disease or eczema?
The research suggests Lactobacillus acidophilus is possibly ineffective for atopic disease, so it may not be the right choice for allergic conditions like eczema.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Pearls Women's is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Pearls Women's label
Go deeper

The Full Monographs Behind Probiotic Pearls Women's’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic Pearls Women's's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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