High Cholesterol Complex Ingredients & Drug Interactions
by TerraVita
What is this page for?
First and foremost: checking High Cholesterol Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
High Cholesterol Complex is a dietary supplement by TerraVita with 2 active ingredients. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 1,022 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggulipid Glycerite Liquid Extract, Artichoke Leaf Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against High Cholesterol Complex by TerraVita
Ask about any prescription or over-the-counter medication and we check it for interactions with High Cholesterol Complex by TerraVita — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of High Cholesterol Complex by TerraVita
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 2 active ingredients in liquid form. The first is artichoke leaf glycerite liquid extract, which comes from the artichoke plant.
The second is guggulipid glycerite liquid extract, derived from the guggul tree resin. Both are delivered in a proprietary blend formula.
The only inactive ingredient listed is glycerin, which is used as a carrier and sweetener in the liquid formulation.
Does it work?
Moderate evidence
Artichoke leaf extract in this product is rated possibly effective for high cholesterol (hyperlipidemia) and digestive upset (dyspepsia). The evidence supporting these uses comes from clinical trials, though the body of research is still modest.
For fatty liver disease (nonalcoholic fatty liver disease, or NAFLD), the evidence isn't established enough to rate. We hold no effectiveness data for guggulipid in our monographs.
How safe is it?
Well-documented data
Artichoke extract is generally well tolerated when used short-term as a supplement, though product quality and dosing can vary. The most common side effects are mild: abdominal pain, diarrhea, gas, increased hunger, and nausea.
Allergic reactions are rare but possible — people sensitive to ragweed, daisies, chrysanthemums, marigolds, or other plants in the Asteraceae family are at higher risk. Severe anaphylaxis to artichoke has been reported in people sensitive to inulin, a compound in artichoke.
Artichoke is not recommended during pregnancy or breastfeeding because there isn't enough safety information.
Meds to double-check
Moderate interaction found
Before you start, check any blood pressure-lowering medications, diabetes drugs, and medications processed by your liver (especially those using CYP2C19 or CYP2B6 pathways) — artichoke may increase their effect or blood levels. If you take any of these, discuss the product with your pharmacist first.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may help with high cholesterol or digestive issues, but you need to check it against your blood pressure and diabetes medications first — artichoke can add to their effects. If you're pregnant, nursing, or allergic to ragweed and related plants, talk with your pharmacist or doctor before starting.
Run your exact medications through the checker below.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about High Cholesterol Complex, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for High Cholesterol Complex by TerraVita, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 0.13 mL | -- |
| Artichoke Leaf Glycerite Liquid Extract | 0 NP | -- |
| Guggulipid Glycerite Liquid Extract | 0 NP | -- |
Other ingredients: Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2018 TerraVita Distributed by ZooScape LLC, All Rights Reserved.
Formula
Glycerite liquid extract (1:5)
Formulation
Alcohol free
No flavor
Suggested/Recommended/Usage/Directions
Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.
Precautions
Keep away from children.
Do not use if safety seal around cap is broken or missing.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
High Cholesterol Complex by TerraVita label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in High Cholesterol Complex by TerraVita
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.
High Cholesterol Complex by TerraVita Drug Interactions
HelloPharmacist Interaction Report
TerraVita's High Cholesterol Complex contains artichoke leaf extract, which has documented interactions with several medication types.
The most serious concern is with blood pressure-lowering drugs (antihypertensives) — artichoke may add to their effect and lower your blood pressure further than intended, a Moderate severity interaction. This risk is supported by clinical evidence showing artichoke can reduce blood pressure on its own.
Read the full breakdown — every affected drug type, severity by severity
Artichoke also interacts with diabetes medications (antidiabetes drugs) at Moderate severity — it may increase the risk of low blood sugar (hypoglycemia) because artichoke itself can reduce blood glucose. Additionally, artichoke may raise levels of drugs broken down by two liver enzymes, CYP2C19 and CYP2B6 substrates, also Moderate severity.
These interactions haven't been seen in humans yet, but lab work shows the potential exists.
We could not check the second active ingredient, Guggulipid Glycerite Liquid Extract, because we hold no interaction data for it. Altogether, these interactions span 360 individual medications.
Use the medication checker on this page to see if any of your prescriptions are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against High Cholesterol Complex?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in High Cholesterol Complex interact with 1,022 drugs. Click any drug to see the details.
2 of the 2 ingredients in High Cholesterol Complex interact with drugs. Each result below shows which ingredient is responsible. Guggulipid Glycerite Liquid Extract Artichoke Leaf Glycerite Liquid Extract
Acetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
How Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interactionAcetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
How Acetaminophen, Dextromethorphan, Pseudoephedrine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Hydrocodone interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Ibuprofen interactionAcetaminophen, OrphenadrineOrfenagesic
How Acetaminophen, Orphenadrine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractCytochrome P450 2b6 (cyp2b6) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
Read the full Artichoke Leaf Glycerite Liquid Extract + Acetaminophen, Orphenadrine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggulipid Glycerite Liquid Extract + Acetylsalicylic Acid interactionAdagrasibKrazati
How Adagrasib interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Adagrasib interactionAerosphere Budesonide, Formoterol Fumarate, GlycopyrrolateBreztri
How Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf Glycerite Liquid Extract + Aerosphere Budesonide, Formoterol Fumarate, Glycopyrrolate interactionAgomelatineValdoxan
How Agomelatine interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
Read the full Artichoke Leaf Glycerite Liquid Extract + Agomelatine interactionAlbiglutideTanzeum
How Albiglutide interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Albiglutide interactionAlfentanilAlfenta
How Alfentanil interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Alfentanil interactionAlfuzosinUroxatral
How Alfuzosin interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Alfuzosin interactionAliskirenTekturna
How Aliskiren interacts with High Cholesterol Complex — through 2 ingredients. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Aliskiren interactionArtichoke Leaf Glycerite Liquid ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Aliskiren interactionAlmotriptanAlmogran, Axert
How Almotriptan interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Almotriptan interactionAlogliptinNesina
How Alogliptin interacts with High Cholesterol Complex — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Alogliptin interactionGuggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with High Cholesterol Complex — through 2 ingredients. Tap an ingredient for the detail:
Artichoke Leaf Glycerite Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Artichoke Leaf Glycerite Liquid Extract + Alogliptin, Pioglitazone interactionGuggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Alogliptin, Pioglitazone interactionAlpelisibPiqray
How Alpelisib interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Alpelisib interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with High Cholesterol Complex — through 1 ingredient. Tap an ingredient for the detail:
Guggulipid Glycerite Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggulipid Glycerite Liquid Extract + Alprazolam interactionEach ingredient & the kinds of drugs it affects
For each ingredient in High Cholesterol Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Guggulipid Glycerite Liquid Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.
Contraceptive Drugs
Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.
Diltiazem (Cardizem, Others)
Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.
Estrogens
Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.
Propranolol (Inderal)
Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.
Rosuvastatin (Crestor)
Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.
Tamoxifen (Nolvadex)
Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Thyroid Hormone
Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.
Artichoke Leaf Glycerite Liquid Extract
Antidiabetes Drugs
Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.
Antihypertensive Drugs
Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.
Brand information
Manufacturer and brand details for High Cholesterol Complex, from the product label.
TerraVita
See all TerraVita products- Name
- ZooScape LLC
- Phone Number
- 844-449-0444
- Web Address
- www.ZooScape.com
High Cholesterol Complex by TerraVita: Common Questions
Does High Cholesterol Complex by TerraVita interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is artichoke leaf extract supposed to do?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects?
Can I use this if I'm allergic to ragweed?
What's in this liquid besides the active ingredients?
Does this product have any interactions we know about for sure?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if High Cholesterol Complex is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind High Cholesterol Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Artichoke
Interacts with 363 drugsArtichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...
Read the full Artichoke monograph → Herb & supplement monographGuggul
Interacts with 757 drugsGuggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...
Read the full Guggul monograph →Sources & How We Checked
High Cholesterol Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Artichoke 16 references
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
- Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
- Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
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