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Dietary supplement

High Potency Sublingual Vitamin B 12 2500 mcg Ingredients & Drug Interactions

by Member's Mark

High Potency Sublingual Vitamin B 12 2500 mcg label
See full label image
Lozenge Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Potency Sublingual Vitamin B 12 2500 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

High Potency Sublingual Vitamin B 12 2500 mcg is a dietary supplement by Member's Mark with 1 active ingredient. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 20 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark

Ask about any prescription or over-the-counter medication and we check it for interactions with High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin B12 at 2,500 micrograms per lozenge. It's a sublingual form, meaning you dissolve it under your tongue for absorption.

The inactive ingredients include mannitol, crospovidone, beet, natural flavor, vegetable magnesium stearate, and sucralose.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Heart, nerve health and energy metabolism.
  • We looked for evidence on: Cardiovascular disease (CVD), Fatigue, Hyperhomocysteinemia, Peripheral neuropathy, Vitamin B12 deficiency, Homocysteine reduction — and 2 related terms.
  • The strongest evidence on file: Vitamin B12 is rated "Effective" for Vitamin B12 deficiency (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Chemotherapy-induced peripheral neuropathy, Fatigue, Peripheral neuropathy.

Vitamin B12 in this product is rated effective for treating Imerslund-Grasbeck disease (a rare genetic condition affecting B12 absorption) and vitamin B12 deficiency itself. It's likely effective for cyanide poisoning.

The data also shows it may be helpful for canker sores and postherpetic neuralgia (nerve pain after shingles), though the evidence for those uses is less established.

The evidence, ingredient by ingredient Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very well tolerated when taken by mouth. Your body removes excess B12 in your urine, so there's no established upper limit for how much is safe.

It's considered safe during pregnancy and breastfeeding at normal recommended amounts—talk with your provider about what's right for you. Allergic reactions are rare but possible and can include rash, itching, or hives; in very rare cases, people with a cobalt allergy have reported skin reactions to oral B12.

Side effects, ingredient by ingredient Vitamin B12

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B12.
  • The most serious interaction on file is rated Minor.
  • For scale: 20 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take metformin (a diabetes medication), check with your doctor or pharmacist before starting this B12 supplement—metformin can interfere with B12 absorption and lower your levels. No other interactions are documented for the ingredients we hold data on, but use the medication checker to confirm your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This high-dose sublingual B12 is a straightforward supplement for treating or preventing B12 deficiency. If you take metformin for diabetes, you and your doctor should discuss whether this supplement makes sense for you, since the medication can lower your B12 over time.

Run your exact medications through the checker on this page, then confirm with your own doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Potency Sublingual Vitamin B 12 2500 mcg, straight from the product label.

Brand Member's Mark
Barcode (UPC) 60538831465
Net contents 2 Bottle(s); 400 Microlozenge(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 13678
Product type Vitamin
Supplement form Lozenge
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Microlozenge(s)
Maximum serving Sizes:
1 Microlozenge(s)
UPC/BARCODE
60538831465
IngredientAmount% DV
Vitamin B122500 mcg--

Other ingredients: Mannitol, Crospovidone, Beet, Natural flavor, Vegetable Magnesium Stearate, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) microlozenge daily. Place microlozenge under tongue for 30 seconds before swallowing.

General Statements

Made in USA.

TWIN PACK

Advantages: - Heart and Nerve Health. - - Supports Energy Metabolism. - High Potency Sublingual Vitamin. - Twin Pack (2 Bottles of 200). - Delicious Natural Cherry Flavor.

Vitamin B-12 prevents megaloblastic anemia by helping to from red blood cells. Vitamin B-12 helps to maintain normal levels of homocysteine which is important for heart and circulatory health. Play an important role in the nervous system and proper function of all body, brain and nerve cells.

Indications:

Heart and Nerve Health

Supports Energy Metabolism Delicious Natural Cherry Flavor

Actual Size

200 MICROLOZENGES

Precautions

Warnings: Keep out of reach of children.

For your protection, do not use if imprinted seal under cap is broken or missing.

Storage

Store in a cool, dry place with lid tightly closed.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

Contains Soy.

Member's Mark - Vitamin B-12 2500 mcg, High Potency, Sublingual B12, 400 Microlozenges

HIGH POTENCY Sublingual Vitamin B 12 2500 mcg

Seals/Symbols

M(R)

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See for yourself

High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Potency Sublingual Vitamin B 12 2500 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Microlozenge(s) Dosage formLozenge Amounts shown are per serving.

Vitamin B12

Interacts with
20 drugs
2500 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Other (inactive) ingredients: Mannitol, Crospovidone, Beet, Natural flavor, Vegetable Magnesium Stearate, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark Drug Interactions

Want to check YOUR meds against High Potency Sublingual Vitamin B 12 2500 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
20Drugs
20 Minor

Ingredients driving the most interactions

Vitamin B12 20

Individual Drug Interactions

The ingredients in High Potency Sublingual Vitamin B 12 2500 mcg interact with 20 drugs. Click any drug to see the details.

1 of the 1 ingredient in High Potency Sublingual Vitamin B 12 2500 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in High Potency Sublingual Vitamin B 12 2500 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Potency Sublingual Vitamin B 12 2500 mcg, from the product label.

Member's Mark

Name
SAM'S West, Inc.
City
Bentonville
State
AR
ZipCode
72716
Pharmacist Counseling Corner

High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark: Common Questions

Does High Potency Sublingual Vitamin B 12 2500 mcg by Member's Mark interact with any medications?
Yes. Based on its ingredients, High Potency Sublingual Vitamin B 12 2500 mcg has a known interaction with 20 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Potency Sublingual Vitamin B 12 2500 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I'm taking metformin?
Metformin can lower your B12 levels over time by interfering with absorption, so if you take it regularly, you may genuinely benefit from supplementing B12. That said, talk it over with your doctor or pharmacist first—they can decide if this dose and form are right for you and whether you need monitoring.
Is it safe to take B12 while I'm pregnant or breastfeeding?
Yes—B12 is considered likely safe at normal recommended amounts during both pregnancy and breastfeeding, and it's actually important at those times. Follow your provider's guidance on the right dose for your situation.
Can too much B12 hurt me?
No. Your body removes excess B12 in your urine, so there's no established upper limit for safety. You're unlikely to overdose on B12 from oral supplements.
What is B12 actually for?
B12 is essential for making red blood cells, protecting your nerves, and supporting energy and brain function. If you don't get enough, you can develop a deficiency that causes fatigue, weakness, and nerve problems.
Can this cause side effects?
When taken by mouth, B12 is generally well tolerated with very few side effects. Allergic reactions are rare but can include rash, itching, or hives; people with a cobalt allergy are at higher risk.
Why is it sublingual instead of a regular pill?
The sublingual form dissolves under your tongue and bypasses some of the digestive system, which may improve absorption—especially helpful if you have absorption problems or take metformin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Potency Sublingual Vitamin B 12 2500 mcg label
Go deeper

The Full Monographs Behind High Potency Sublingual Vitamin B 12 2500 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

High Potency Sublingual Vitamin B 12 2500 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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