Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

High Test Ingredients & Drug Interactions

by BioXgenic

High Test label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking High Test against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

High Test is a dietary supplement by BioXgenic with 5 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 1,320 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against High Test by BioXgenic

Ask about any prescription or over-the-counter medication and we check it for interactions with High Test by BioXgenic — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of High Test by BioXgenic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 14 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (2,015 mg) without saying how much of each component you get.
  • “Hormone Releasing X Complex” is a proprietary blend — the label gives one combined amount (525 mg) without saying how much of each component you get.
  • “Natural Factors X Complex” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

High Test contains 14 ingredients, including a proprietary blend. The active components are zinc, an amino acid blend (L-tyrosine, L-glutamine, L-arginine, L-lysine, and L-ornithine), oat extract, black pepper extract (BioPerine), GABA, and plant extracts including saw palmetto, tribulus terrestris, Eurycoma longifolia, beta-sitosterol, and fenugreek (Testofen).

The inactive ingredients are gelatin, stearic acid, magnesium stearate, microcrystalline cellulose, titanium dioxide, silica, and FD&C Blue #1.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: testosterone support and prostate health.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Benign prostatic hyperplasia (BPH), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), erectile function, male fertility — and 1 related terms.
  • The strongest evidence on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Ornithine is rated "Possibly Effective" for Athletic performance.
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.

Evidence for this product's active ingredients is mixed. Zinc is effective for zinc deficiency and likely effective for Wilson disease; it's possibly effective for acne and age-related macular degeneration.

Oats are likely effective for high cholesterol and heart health. L-tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory.

L-glutamine is effective for sickle cell disease and possibly effective for recovery after surgery and critical illness. L-lysine is possibly effective for cold sores.

Tribulus terrestris and fenugreek are each possibly effective for sexual function. For the other ingredients—black pepper, L-arginine, GABA, L-ornithine, Eurycoma longifolia, and saw palmetto—we hold insufficient evidence, or the data shows possibly ineffective or insufficient reliable evidence to establish benefit.

Because this is a combination product, we cannot predict how these ingredients perform together.

The evidence, ingredient by ingredient Zinc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 13 of the 14 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 14 of 14.
  • General safety write-ups exist for 14 of 14.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zinc is generally well tolerated below 40 mg daily, though higher doses can cause copper deficiency. Common side effects are nausea, diarrhea, metallic taste, and abdominal cramps.

Black pepper is generally well tolerated as a food spice; concentrated supplements should be used cautiously. L-tyrosine is generally well tolerated in healthy adults; common side effects include fatigue, headache, nausea, and heartburn.

L-glutamine is generally well tolerated, though high doses (10–30 grams daily) may cause nausea, vomiting, constipation, or gastrointestinal pain. Oats are well tolerated; increased fiber can cause bloating and flatulence initially.

L-arginine is generally well tolerated short-term but can lower blood pressure; side effects include abdominal pain, bloating, nausea, diarrhea, and headache. GABA is generally well tolerated short-term; common side effects are drowsiness, nausea, and muscle weakness.

Saw palmetto is well tolerated; rare cardiac side effects have been reported. Tribulus terrestris and fenugreek are generally well tolerated short-term, though rare cases of liver and kidney injury, and allergic reactions (fenugreek), have been reported.

Side effects, ingredient by ingredient Zinc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 12 of the 14 matched ingredients can interact with medications — Tribulus, Lysine, Gamma-aminobutyric Acid (gaba), Fenugreek, Black Pepper, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 1,321 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking High Test, check with your doctor or pharmacist if you take antibiotics (quinolones, tetracyclines, or cephalexin), blood thinners or antiplatelet drugs, blood pressure medications, diabetes medications or insulin, seizure medications (phenytoin or anticonvulsants), thyroid hormones, contraceptives or estrogen, potassium-sparing diuretics, lithium, or HIV medications (ritonavir, integrase inhibitors, or nevirapine). These are the drug types with documented moderate interactions; other medications may also interact.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

High Test is a combination product designed to support performance and testosterone. If you take medications for blood pressure, diabetes, seizures, blood clotting, or thyroid or hormone conditions, or if you take any antibiotic or HIV medication, you need to check your exact drugs against the interaction tool below before starting this product.

Talk with your doctor or pharmacist about whether it's appropriate for you and whether any dosing adjustments are needed for your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 14 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about High Test, straight from the product label.

Brand BioXgenic
Barcode (UPC) 699439000325
Net contents 45 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 277318
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for High Test by BioXgenic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
15
UPC/BARCODE
699439000325
IngredientAmount% DV
Proprietary Blend2015 mg--
Zinc30 mg273%
BioPerine0 NP--
L-Tyrosine0 NP--
L-Glutamine0 NP--
Avena sativa extract0 NP--
L-Arginine0 NP--
L-Lysine0 NP--
Gamma-Aminobutyric Acid0 NP--
L-Ornithine0 NP--
Beta-Sitosterol0 NP--
Eurycoma longifolia extract0 NP--
Saw Palmetto Berry Extract0 NP--
Hormone Releasing X Complex525 mg--
Natural Factors X Complex500 mg--
Tribulus terrestris0 NP--
Prostate Safety X Complex390 mg--
Testosterone Boosting X Complex600 mg--
Testofen0 NP--

Other ingredients: Gelatin, Stearic Acid, Magnesium Stearate, Microcrystalline Cellulose, Titanium Dioxide, Silica, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Our advanced formula offers a unique three-pronged testosterone boosting formula with a fourth prong that supports the prostate.

Increases testosterone naturally Promotes lean body mass & strength Libido & energy enhancer Supports prostate health

Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule three (3) times a day. For maximum effectiveness, this product should be used daily.

Precautions

Caution: For men only.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under the age of 18, have a medical condition or hormone-related cancer.

Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under the age of 18, have a medical condition or hormone-related cancer.

Use only as directed. Do not exceed recommended daily intake. Discontinue use two weeks prior to surgery.

Keep out of the reach of children.

Formula

Caution: For men only.

Contains a clinically proven testosterone booster Testofen

Storage

Store tightly closed in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Please visit BioXgenic.com to read the Testofen clinical study.

Brand IP Statement(s)

BioXgenic Naturally supporting sexual health

BioPerine is a trademark of Sabinsa Corporation Testofen and Fenuside are trademarks of Gencor Pacific, Inc.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

High Test by BioXgenic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

High Test label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in High Test by BioXgenic

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

2015 mg per serving
  • › Hormone Releasing X Complex
  • › Natural Factors X Complex
  • › Prostate Safety X Complex
  • › Testosterone Boosting X Complex

Zinc

Interacts with
67 drugs
30 mg per serving Form: Zinc Oxide

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Other (inactive) ingredients: Gelatin, Stearic Acid, Magnesium Stearate, Microcrystalline Cellulose, Titanium Dioxide, Silica, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

High Test by BioXgenic Drug Interactions

Want to check YOUR meds against High Test?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,320Drugs
1,201 Moderate 119 Minor

Ingredients driving the most interactions

Zinc 67

Individual Drug Interactions

The ingredients in High Test interact with 1,320 drugs. Click any drug to see the details.

1 of the 5 ingredients in High Test interact with drugs. Each result below shows which ingredient is responsible. Zinc

Each ingredient & the kinds of drugs it affects

For each ingredient in High Test with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for High Test, from the product label.

BioXgenic

See all BioXgenic products
Name
BioXgenic LLC
City
Pompano Beach
State
FL
ZipCode
33069
Phone Number
954-725-5502
Web Address
BioXgenic.com
Pharmacist Counseling Corner

High Test by BioXgenic: Common Questions

Does High Test by BioXgenic interact with any medications?
Yes. Based on its ingredients, High Test has a known interaction with 1,320 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
High Test contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take High Test if I'm on blood pressure medication?
Several ingredients—L-arginine, tribulus, and potentially black pepper—can lower blood pressure. Taking them with blood pressure medications could increase the risk of dangerously low blood pressure. Talk with your doctor before adding this product to your regimen.
Will this interact with my diabetes medication or insulin?
Yes. Oats, L-arginine, tribulus, and fenugreek can all lower blood sugar. Combined with diabetes medication or insulin, they may increase the risk of low blood sugar (hypoglycemia). Your doctor may need to adjust your medication dose if you use this product.
Is High Test safe to take while pregnant?
Zinc is likely safe in pregnancy, and L-glutamine is likely safe. However, fenugreek, tribulus, Eurycoma longifolia, beta-sitosterol, and saw palmetto should be avoided or are likely unsafe in pregnancy because of hormonal effects or insufficient safety data. Talk with your doctor or pharmacist before using this product if you are pregnant.
What's zinc in this product for?
Zinc supports immune function and is effective for zinc deficiency. It's also possibly effective for acne and age-related eye health. However, if you take certain antibiotics or HIV medications, zinc can interfere with how your body absorbs them.
Does this product have side effects?
The most common side effects from individual ingredients are nausea, diarrhea, abdominal discomfort, headache, bloating, and a metallic taste. Most are mild and dose-related. Rare serious side effects—such as liver or kidney injury with tribulus—have been reported in individual cases.
Can I take this if I'm on an antibiotic?
It depends on which antibiotic. Zinc can significantly reduce how your body absorbs quinolones, tetracyclines, and cephalexin by 27–40%, making them less effective. You would need to take zinc and your antibiotic several hours apart. Ask your pharmacist or doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

High Test label
Go deeper

The Full Monographs Behind High Test’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph →
Sources

Sources & How We Checked

High Test's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 304 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  9. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
  10. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
  11. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
  12. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  13. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
  14. Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
  15. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
  16. Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
  17. Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
  18. Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
  19. Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
  20. Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
  21. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  22. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
  23. Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
  24. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
  25. Turner RB. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Clin Infect Dis 2001;33:1865-70. PubMed
  26. Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Am J Med 2001;111:103-8. PubMed
  27. Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM 2003;96:35-43. DOI
  28. Leitzmann MF, Stampfer MJ, Wu K, et al. Zinc supplement use and risk of prostate cancer. J Natl Cancer Inst 2003;95:1004-7.. PubMed
  29. Jafek BW, Linschoten M, Murrow BW. Zicam Induced Anosmia. American Rhinologic Society 49th Annual Fall Scientific Meeting abstract. Orlando, Florida. September 20, 2003. http://app.american-rhinologic.org/programs/2003ARSFallProgram071503.pdf (Accessed 24
  30. Uebayashi H, Hatanaka T, Kanemura F, Tonosaki K. Acute anosmia in the mouse: behavioral discrimination among the four basic taste substances. Physiol Behav 2001;72:291-6.. PubMed
  31. Barrett S. Zicam Marketers Sued. United States District Court Western District of Michigan Southern Division, Filed October 14, 2003, Case No. 4:03CV0146.
  32. Bilici M, Yildirim F, Kandil S, et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:181-90.. PubMed
  33. Polk RE, Healy DP, Sahai J, et al. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother 1989;33:1841-4. PubMed
  34. Mery C, Delrieu F, Ghozlan R, et al. Controlled trial of D-penicillamine in rheumatoid arthritis. Dose effect and the role of zinc. Scand J Rheumatol 1976;5:241-7. PubMed
  35. Penttila O, Hurme H, Neuvonen PJ. Effect of zinc sulfate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol 1975;9:131-4.
  36. Kondo Y, Yamagata K, Satoh M, et al. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. J Urol 2003;170:2467-70. PubMed
  37. Doz F, Berens ME, Deschepper CF, et al. Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum(II) in brain tumor therapy by a high-zinc diet. Cancer Chemother Pharmacol 1992;29:219-26.
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  22. Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a doubl
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  25. Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed
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  27. Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
  28. Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
  29. Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
  30. Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.

See these in context on the Fenugreek monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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