Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

HistaQuel Ingredients & Drug Interactions

by Researched Nutritionals

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

HistaQuel is a dietary supplement by Researched Nutritionals with 6 active ingredients. Its ingredients are commonly taken for seasonal and food allergies, asthma and airway inflammation, atopic dermatitis (eczema).Based on those ingredients, 251 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nettle, Butterbur root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of HistaQuel by Researched Nutritionals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Mast Cell Secure” is listed as a grouped ingredient — the label gives one combined amount (460 mg) without saying how much of each component you get.
  • “HistaCheck” is listed as a grouped ingredient — the label gives one combined amount (380 mg) without saying how much of each component you get.

HistaQuel contains 6 active ingredients designed to support histamine response and allergy relief. Butterbur root extract and nettle are both traditionally used for allergic rhinitis (hay fever) and have some evidence supporting their use, though the strength of that evidence differs.

Quercefit, Luteolin, Fisetin, and Perilla frutescens leaf extract round out the formula with compounds from plant sources. There are also three inactive ingredients—hypromellose, rice, and L-leucine—which serve as capsule material and stabilizers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Comprehensive allergy support and histamine management.
  • We looked for evidence on: Allergic rhinitis (hay fever), Asthma, Atopic dermatitis (eczema), Headache, Migraine headache, Mast cell activation — and 2 related terms.
  • The strongest evidence on file: Butterbur is rated "Possibly Effective" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Butterbur is rated "Possibly Effective" for Migraine headache.
  • Also on file: Butterbur is rated "Possibly Ineffective" for Atopic dermatitis (eczema).

The evidence supporting HistaQuel's ingredients is mixed. Butterbur root extract is possibly effective for migraine headaches and hay fever—two of the main uses people reach for it for.

Nettle is possibly effective for diabetes-related blood sugar control, but for hay fever and other conditions it's backed by insufficient evidence. For the other ingredients—Quercefit, Luteolin, Fisetin, and Perilla—either we don't have effectiveness data on file, or the evidence is rated as insufficient to make a judgment.

If you're considering this product for a specific condition, talk with your pharmacist about which ingredients address your concern.

The evidence, ingredient by ingredient Perilla Butterbur Stinging Nettle

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Butterbur and nettle are generally well tolerated when used as directed, but each comes with important caveats. Butterbur's main safety concern is that raw forms and some supplements contain liver-damaging compounds called pyrrolizidine alkaloids; HistaQuel should use PA-free extract, and the product label should confirm this.

Common side effects from butterbur include belching, diarrhea, drowsiness, fatigue, headache, and stomach upset. Nettle's most common side effects are constipation and diarrhea.

A rare case of liver injury has been reported with a nettle-containing herbal product, though causality was unclear. Perilla carries a rare risk of anaphylaxis (severe allergic reaction), especially in people with seed allergies.

Neither butterbur nor nettle should be used during pregnancy or breastfeeding—the safety data advises against it. Perilla and luteolin lack sufficient safety data in pregnancy and breastfeeding; talk with your doctor before using during those times.

Quercefit and Fisetin have no pregnancy/breastfeeding information on file.

Side effects, ingredient by ingredient Perilla Butterbur Stinging Nettle

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Butterbur, Stinging Nettle.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 252 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking HistaQuel, double-check with your pharmacist if you're on warfarin or other blood thinners (nettle may reduce their effect), diabetes medications (nettle may lower blood sugar additively), diuretics (nettle's diuretic effect may add to theirs), or lithium (nettle may raise its levels). Also mention any medications that induce CYP3A4, a liver enzyme—butterbur could theoretically become more toxic if that enzyme speeds up.

No interactions are documented for the other checked ingredient, perilla, but allergies to seeds should be reported.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

HistaQuel may help with hay fever and migraines if the butterbur extract is PA-free, but it carries documented interactions with diabetes drugs, diuretics, lithium, and warfarin. If you take any prescription medication—especially the types above—check your exact drugs with the tool on this page before starting.

Pregnant or breastfeeding? Talk with your doctor first.

Ask your pharmacist to verify the butterbur is PA-free and to flag any conflicts with your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HistaQuel, straight from the product label.

Brand Researched Nutritionals
Barcode (UPC) 893295002596
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Apr 21, 2023
DSLD ID 294088
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HistaQuel by Researched Nutritionals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
893295002596
IngredientAmount% DV
Quercefit0 NP--
Butterbur root extract0 NP--
Luteolin0 NP--
Nettle0 NP--
Mast Cell Secure460 mg--
Perilla frutescens leaf extract0 NP--
Fisetin0 NP--
HistaCheck380 mg--

Other ingredients: Hypromellose, Rice, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take two capsules twice per day with or without meals, or use as directed by your healthcare professional.

Precautions

Caution: If pregnant or nursing, consult your healthcare professional before use.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General Statements

Available only through health care professionals.

Brand IP Statement(s)

Researched Nutritionals Solutions for life

Quercefit is a registered trademark of Indena

Formulation

Comprehensive allergy support Supports normal histamine production Promotes healthy mast cell function

GMO-free

Free of: milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, corn and gluten.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

HistaQuel by Researched Nutritionals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in HistaQuel by Researched Nutritionals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Mast Cell Secure

460 mg per serving

HistaCheck

380 mg per serving

Other (inactive) ingredients: Hypromellose, Rice, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

HistaQuel by Researched Nutritionals Drug Interactions

Want to check YOUR meds against HistaQuel?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
251Drugs
251 Moderate

Ingredients driving the most interactions

Nettle 164

Each ingredient & the kinds of drugs it affects

For each ingredient in HistaQuel with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Nettle4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D

Butterbur root extract1 drug type · 87 drugs

Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, CYP3A4 inducers might increase the toxicity of butterbur.
The pyrrolizidine alkaloid (PA) constituents found in some butterbur products are substrates of CYP3A4. Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for HistaQuel, from the product label.

Researched Nutritionals

See all Researched Nutritionals products
Name
Researched Nutritionals, LLC
City
Los Olivos
State
CA
ZipCode
93441
Phone Number
1-800-755-3402
Web Address
www.ResearchedNutritionals.com
Pharmacist Counseling Corner

HistaQuel by Researched Nutritionals: Common Questions

Does HistaQuel by Researched Nutritionals interact with any medications?
Yes. Based on its ingredients, HistaQuel has a known interaction with 251 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HistaQuel contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is the butterbur in HistaQuel safe for my liver?
HistaQuel should contain PA-free butterbur extract to be safe—raw butterbur can damage the liver because of compounds called pyrrolizidine alkaloids. Check the label to confirm it's PA-free, and let us know if you have questions about the brand's standardization.
Can I take this while I'm pregnant or breastfeeding?
The safety data advises against using butterbur and nettle during pregnancy and breastfeeding. Perilla, luteolin, and quercefit lack enough safety data in these situations—talk with your doctor before use. It's an individual decision that depends on your specific health.
What are the most common side effects?
Butterbur commonly causes belching, diarrhea, drowsiness, fatigue, and stomach upset. Nettle's most common side effects are constipation and diarrhea. Most people tolerate both well, but side effects can happen.
Does this product actually help with allergies?
Butterbur is possibly effective for hay fever, and nettle is also used for it, though the evidence for nettle is insufficient. Results vary by person. If you've had seasonal allergies before, this combination may help, but it's not a guarantee.
What is perilla leaf extract used for in this formula?
Perilla is included in the formula for its traditional use in allergy and respiratory support, though the evidence for its effectiveness is rated as insufficient. It's generally well tolerated, but rare anaphylaxis has been reported in people with seed allergies.
Why does this product have so many ingredients?
Each ingredient—butterbur, nettle, perilla, and the others—targets different aspects of histamine response and allergy support. Together they're meant to work as a multi-target formula, though only butterbur and nettle have solid evidence for hay fever and migraine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HistaQuel is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HistaQuel label
Sources

Sources & How We Checked

HistaQuel's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 34 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Butterbur 7 references
  1. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache 2003;43:76-8.. PubMed
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  5. Pothmann R, Danesch U. Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. Headache 2005;45:196-203.. PubMed
  6. Oelkers-Ax R, Leins A, Parzer P, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain 2008;12:301-13. PubMed
  7. Schapowal A. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Arch Otolaryngol.Head Neck Surg. 2004;130:1381-86. PubMed

See these in context on the Butterbur monograph →

Stinging Nettle 23 references
  1. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  5. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  6. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  7. Mittman P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 1990;56:44-7.
  8. Vontobel HP, Herzog R, Rutishauser G, Kres H. [Results of a double-blind study on the effectiveness of ERU (extractum radicis Urticae) capsules in conservative treatment of benign prostatic hyperplasia]. (Abstract). Urologe A 1985;24:49-51.
  9. Randall C, Randall H, Dobbs F, et al. Randomized controlled trial of nettle sting for treatment of base-of-thumb pain. J R Soc Med 2000;93:305-9. PubMed
  10. Caliskaner Z, Karaayvaz M, Ozturk S. Misuse of a herb: stinging nettle (Urtica urens) induced severe tongue oedema. Complement Ther Med 2004;12:57-8. PubMed
  11. Krzeski, T., Kazon, M., Borkowski, A., Witeska, A., and Kuczera, J. Combined extracts of Urtica dioica and Pygeum africanum in the treatment of benign prostatic hyperplasia: double-blind comparison of two doses. Clin Ther 1993;15(6):1011-1020.
  12. Randall, C., Meethan, K., Randall, H., and Dobbs, F. Nettle sting of Urtica dioica for joint pain--an exploratory study of this complementary therapy. Complement Ther Med 1999;7(3):126-131. PubMed
  13. Tahri, A., Yamani, S., Legssyer, A., Aziz, M., Mekhfi, H., Bnouham, M., and Ziyyat, A. Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000;73(1-2):95-100. PubMed
  14. Sahin, M., Yilmaz, H., Gursoy, A., Demirel, A. N., Tutuncu, N. B., and Guvener, N. D. Gynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica). N.Z.Med.J. 2007;120(1265):U2803.
  15. Randall, C., Dickens, A., White, A., Sanders, H., Fox, M., and Campbell, J. Nettle sting for chronic knee pain: a randomised controlled pilot study. Complement Ther.Med. 2008;16(2):66-72. PubMed
  16. Rayburn, K., Fleischbein, E., Song, J., Allen, B., Kundert, M., Leiter, C., and Bush, T. Stinging nettle cream for osteoarthritis. Altern.Ther.Health Med. 2009;15(4):60-61.
  17. Oliver, F., Amon, E. U., Breathnach, A., Francis, D. M., Sarathchandra, P., Black, A. K., and Greaves, M. W. Contact urticaria due to the common stinging nettle (Urtica dioica)-- histological, ultrastructural and pharmacological studies. Clin Exp Dermato PubMed
  18. Kulze, A. and Greaves, M. Contact urticaria caused by stinging nettles. Br.J Dermatol. 1988;119(2):269-270. PubMed
  19. Patten G. Medicinal plant review: Urtica. Aust J Med Herbalism 1993;5(1):5-13.
  20. Maor D, Little M. Skin contact with a stinging tree requiring intensive care unit admission. Contact Dermatitis. 2017 Nov;77(5):335-37. PubMed
  21. Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJ. Stinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea. Am J Case Rep 2021;22:e933999. PubMed
  22. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
  23. Nnamani I, Tolu-Akinnawo O, Dufera RR, Akintunde A, Maliakkal B. Tinospora cordifolia (Guduchi/Giloy)-Induced Liver Injury: A Case Review. Cureus 2023;15(5):e39793. PubMed

See these in context on the Stinging Nettle monograph →

Perilla 4 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
  3. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
  4. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

See these in context on the Perilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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