Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

HMB 1000 mg Ingredients & Drug Interactions

by GNC Pro Performance

HMB 1000 mg label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HMB 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HMB 1000 mg is a dietary supplement by GNC Pro Performance with 2 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Monopotassium Phosphate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HMB 1000 mg by GNC Pro Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with HMB 1000 mg by GNC Pro Performance — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of HMB 1000 mg by GNC Pro Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: monopotassium phosphate, which provides potassium, and HMB (beta-hydroxy beta-methylbutyrate), a compound involved in muscle protein metabolism. The inactive ingredients are dicalcium phosphate, cellulose, and vegetable acetoglycerides—typical tablet binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: helps prevent muscle breakdown with exercise.
  • We looked for evidence on: muscle atrophy, sarcopenia, muscle wasting.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts we hold do not include effectiveness ratings for either ingredient, so we cannot tell you what the evidence says about how well HMB works for its intended purpose.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium from food is safe, but supplements carry real risks. The main concern is that potassium can accumulate to dangerously high levels in your blood, especially if you have kidney disease or take certain blood pressure medications.

People with healthy kidneys who eat a normal diet rarely have this problem, but supplement use requires medical oversight. Common side effects from oral potassium are abdominal pain, belching, diarrhea, flatulence, nausea, and vomiting.

Rare but serious effects include irregular heartbeat, low blood pressure, and mental confusion—all signs your potassium level is too high. During pregnancy, dietary potassium is fine, but potassium supplements should only be used with medical guidance; the same applies while breastfeeding.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any potassium-sparing diuretics (such as spironolactone), ACE inhibitors (like lisinopril or enalapril), or angiotensin receptor blockers (like losartan or valsartan). All three types raise the risk of dangerously high blood potassium when combined with potassium supplements.

We could not check the second ingredient, HMB, for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is potassium-based, so it's not for everyone—particularly if you take blood pressure medications, have kidney disease, or already eat a potassium-rich diet. Talk to your doctor or pharmacist before starting it; they can check whether it's right for your kidney function and your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HMB 1000 mg, straight from the product label.

Brand GNC Pro Performance
Barcode (UPC) 048107169077
Net contents 240 Tablet(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74748
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HMB 1000 mg by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
60
UPC/BARCODE
048107169077
IngredientAmount% DV
Monopotassium Phosphate200 mg--
HMB1000 mg--

Other ingredients: Dicalcium Phosphate, Cellulose, Vegetable Acetoglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

When used in conjunction with an exercise program.

Helps prevent muscle breakdown

Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

General

CODE 987512 DRG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take four tablets three times daily with meals. Do not exceed recommended intake levels.

Formula

HMB

Brand IP Statement(s)

Nutritional uses of calcium B-hydroxy B-methylbutyrate menohydrate are licensed to GNC under U.S. Patent #6,103,764. Use of the trademark is licensed from Metabolic Technologies.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HMB 1000 mg by GNC Pro Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HMB 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HMB 1000 mg by GNC Pro Performance

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Monopotassium Phosphate

Interacts with
62 drugs
200 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Monopotassium Phosphate monograph & interactions

HMB

1000 mg per serving Form: Calcium Hydroxymethyl Butyrate Monohydrate

Other (inactive) ingredients: Dicalcium Phosphate, Cellulose, Vegetable Acetoglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

HMB 1000 mg by GNC Pro Performance Drug Interactions

Want to check YOUR meds against HMB 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Monopotassium Phosphate 62

Individual Drug Interactions

The ingredients in HMB 1000 mg interact with 62 drugs. Click any drug to see the details.

1 of the 2 ingredients in HMB 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Monopotassium Phosphate

Each ingredient & the kinds of drugs it affects

For each ingredient in HMB 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Monopotassium Phosphate3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Monopotassium Phosphate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HMB 1000 mg, from the product label.

GNC Pro Performance

See all GNC Pro Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
www.gnc.com
Pharmacist Counseling Corner

HMB 1000 mg by GNC Pro Performance: Common Questions

Does HMB 1000 mg by GNC Pro Performance interact with any medications?
Yes. Based on its ingredients, HMB 1000 mg has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HMB 1000 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have high blood pressure?
Only with your doctor's approval—it depends on which blood pressure medication you take. Some classes, especially ACE inhibitors and ARBs, don't mix safely with potassium supplements because they already reduce how much potassium your kidneys excrete. Talk to your doctor or pharmacist about your specific medication before starting.
What are the common side effects?
The most frequent complaints are abdominal pain, belching, diarrhea, bloating, nausea, and vomiting. These tend to be mild. Serious effects—irregular heartbeat, low blood pressure, and confusion—are rare but signal dangerously high blood potassium and need immediate medical attention.
Is it safe to take while pregnant or breastfeeding?
Potassium from your normal diet is safe during pregnancy and breastfeeding, but supplements should only be used under medical guidance in both cases. Talk to your doctor or pharmacist before taking this product if you're pregnant or nursing.
What is HMB and what does it do?
HMB stands for beta-hydroxy beta-methylbutyrate. It's a compound involved in how your body builds and maintains muscle protein, but the effectiveness data we hold doesn't tell us how well it works for that purpose.
Do I need to worry about kidney disease?
Yes—potassium supplements can be risky if you have kidney disease because your kidneys may not excrete excess potassium safely, leading to dangerously high levels. If you have any kidney concerns, talk to your doctor or pharmacist before taking this product.
Can I take this if I eat a lot of potassium-rich foods?
Not without checking first. Potassium from food is usually fine, but adding a supplement on top of a high-potassium diet can push levels too high, especially if you take certain blood pressure medications or have kidney issues. Run it past your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HMB 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HMB 1000 mg label
Go deeper

The Full Monographs Behind HMB 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

HMB 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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