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Dietary supplement

HMF Natogen Ingredients & Drug Interactions

by Genestra Brands

HMF Natogen label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking HMF Natogen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

HMF Natogen is a dietary supplement by Genestra Brands with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Consortium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against HMF Natogen by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with HMF Natogen by Genestra Brands — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of HMF Natogen by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Probiotic Consortium” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

HMF Natogen contains three active probiotic ingredients — two strains of Lactobacillus (paracasei and acidophilus) and one strain of Bifidobacterium. These are beneficial live bacteria meant to support your gut health.

The powder also contains lactose monohydrate as an inactive ingredient.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Probiotic support for digestive and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Rotaviral diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections, Constipation, Lactose intolerance, Rotaviral diarrhea.

The evidence we hold covers Lactobacillus acidophilus. It's rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

It's rated possibly ineffective for atopic disease (eczema and related conditions), and the evidence for acute respiratory distress syndrome is too limited to rate. We don't have effectiveness data on file for the other two probiotic strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Some people taking it with other probiotics have reported mild gastrointestinal side effects like abdominal discomfort, bloating, flatulence, or diarrhea, but these are uncommon.

In rare cases, live probiotic organisms have been linked to serious infections in vulnerable patients. Since the safety data on this product are limited, check with your doctor before use, especially if you have a weakened immune system or are at risk for infection.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, tell your pharmacist — Lactobacillus acidophilus can lose effectiveness if you take them at the same time. We couldn't check two of the three active ingredients in this product against our data, so the interaction list may not be complete.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may be worth considering if you have IBS, antibiotic-related diarrhea, or bacterial vaginosis, since Lactobacillus acidophilus has some supporting evidence for those uses. If you take antibiotics, space them apart from this product so the live bacteria don't get killed.

Check with your pharmacist first if you have a compromised immune system or serious illness.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about HMF Natogen, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 883196102747
Net contents 6 Gram(s); 0.21 Ounce(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 321212
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Gluten Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for HMF Natogen by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
100 mg
Maximum serving Sizes:
100 mg
Servings per container
60
UPC/BARCODE
883196102747
IngredientAmount% DV
Lactobacillus paracasei CUL-080 NP--
Bifidobacterium animalis lactis CUL-620 NP--
Lactobacillus acidophilus0 NP--
Probiotic Consortium0 NP--

Other ingredients: Lactose Monohydrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Contains: Milk

Warning: If your child has any health condition or is taking any medication, consult your health professional before use. Caution: If your child is immunocompromised, consult your health professional before using probiotic-containing products. Keep out of the reach of children.

Warning: If your child has any health condition or is taking any medication, consult your health professional before use.

This product was sealed for your protection. Do not use if box or contents are open or damaged.

Formulation

Genestra HMF (Human Microflora) Probiotics offer: Clinically studied, proprietary strains Doctor-recommended for over 20 years Research-driven, condition-specific formulas Potency guaranteed through expiration

Clinically studied, recommended by doctors for more than 20 years

Supports gastrointestinal health

No artificial colors or flavors Non GMO Gluten free Soy free No FOs

Vegetarian

Suggested/Recommended/Usage/Directions

Recommended dose: Children (1-4 years): In a glass add water or milk to 1 scoop of HMF Natogen and mix. Take once daily with a meal or as recommended by your health professional.

Storage

Store under refrigeration (below 46 degrees F).

Packaged by weight, not volume. Settling may occur.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Scan to learn about our quality excellence

FDA Statement of Identity

Daily Probiotic Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

HMF Natogen by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

HMF Natogen label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in HMF Natogen by Genestra Brands

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size100 mg Dosage formPowder Servings per container60 Amounts shown are per serving.

Probiotic Consortium

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Consortium monograph & interactions

Other (inactive) ingredients: Lactose Monohydrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

HMF Natogen by Genestra Brands Drug Interactions

Want to check YOUR meds against HMF Natogen?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Consortium 182

Individual Drug Interactions

The ingredients in HMF Natogen interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in HMF Natogen interact with drugs. Each result below shows which ingredient is responsible. Probiotic Consortium

Each ingredient & the kinds of drugs it affects

For each ingredient in HMF Natogen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Consortium1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Consortium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for HMF Natogen, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

HMF Natogen by Genestra Brands: Common Questions

Does HMF Natogen by Genestra Brands interact with any medications?
Yes. Based on its ingredients, HMF Natogen has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
HMF Natogen contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. Antibiotics can kill the live bacteria in this probiotic, making it less effective. Ask your pharmacist or doctor how to space them — usually a few hours apart helps.
What are probiotics, and what do they do?
Probiotics are beneficial live bacteria. This product contains three strains. Lactobacillus acidophilus in particular has some evidence for helping with IBS, antibiotic-related diarrhea, and a few other conditions, though the evidence isn't definitive.
Will this give me side effects?
Most people tolerate it well. Rarely, people taking probiotics report mild stomach discomfort, bloating, or diarrhea. Serious infections from probiotics are very uncommon but have happened in people with weakened immune systems.
Is this safe if I'm pregnant or breastfeeding?
We don't have safety data on file for this product in pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's okay for you before you start.
Does this product contain any allergens?
Yes — it contains lactose monohydrate. If you're lactose intolerant or allergic to dairy, you'll want to skip this one or check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if HMF Natogen is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

HMF Natogen label
Go deeper

The Full Monographs Behind HMF Natogen’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

HMF Natogen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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