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Dietary supplement

Hoodia Ingredients & Drug Interactions

by L.A. Naturals

Hoodia label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hoodia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hoodia is a dietary supplement by L.A. Naturals with 1 active ingredient. Its ingredients are commonly taken for appetite suppression, weight loss, reducing food cravings.Based on those ingredients, 262 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are selectively imported Hoodia gordonii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hoodia by L.A. Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Hoodia by L.A. Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hoodia by L.A. Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains a single active ingredient: selectively imported Hoodia gordonii, a plant traditionally used as an appetite suppressant. The liquid form also includes vegetable glycerin and deionized water as inactive ingredients to deliver the hoodia extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hoodia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: appetite suppression and weight loss support.
  • We looked for evidence on: Obesity, weight management, food cravings, hunger control.
  • The closest evidence on file: Hoodia is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence we hold doesn't establish that hoodia is reliably effective for obesity. The data shows insufficient reliable evidence to rate it for this purpose.

If weight management is your goal, talk with your doctor or pharmacist about approaches with stronger supporting data.

The evidence, ingredient by ingredient Hoodia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hoodia has limited safety data. Orally, it's been reported to cause minor side effects including skin sensation disturbances, headache, dizziness, lightheadedness, and nausea.

There's also concern that it may increase blood pressure and heart rate. The safety data advises against use during pregnancy and while breastfeeding due to insufficient information.

Side effects, ingredient by ingredient Hoodia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hoodia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking L.A. Naturals Hoodia, double-check with your doctor or pharmacist if you take blood pressure medications (antihypertensives), beta-blockers, diabetes drugs, or insulin.

Hoodia may reduce how well blood pressure and heart medications work, and it may enhance blood sugar-lowering effects and raise the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

L.A. Naturals Hoodia may appeal to someone looking for a plant-based appetite suppressant, but the evidence for weight loss is weak and safety data are limited.

If you take medications for blood pressure, heart rate, or blood sugar, this product carries real interaction risks — check with your doctor or pharmacist before adding it. Anyone pregnant or breastfeeding should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hoodia, straight from the product label.

Brand L.A. Naturals
Barcode (UPC) 641356117815
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jul 25, 2014
DSLD ID 34886
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hoodia by L.A. Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
641356117815
IngredientAmount% DV
selectively imported Hoodia gordonii0 NP--

Other ingredients: Vegetable Glycerin, deionized Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take 1 dropperful (30 drops) in a large glass of water 15-30 minutes before each meal. Repeat more often for faster results.

Shake well before using.

Precautions

WARNING: Do not take during pregnancy.

Keep out of the reach of children.

General Statements

Plant # K-0001604

MADE IN THE USA

FAST ABSORPTION MEDICINAL BOTANICALS ALCOHOL FREE SINGLE HERB

True South African

Herb Strength Ratio 4:1

VERIFIED THROUGH 3RD PARTY ANALYTICAL TESTING

250 mg Herb Weight Equivalence

Seals/Symbols

L.a.(TM)

K PARVE

Formulation

ALCOHOL FREE

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hoodia by L.A. Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hoodia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hoodia by L.A. Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Selectively imported Hoodia gordonii

Interacts with
262 drugs
0 NP per serving

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actuall...

Selectively imported Hoodia gordonii monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Deionized Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hoodia by L.A. Naturals Drug Interactions

Want to check YOUR meds against Hoodia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
262Drugs
262 Moderate

Ingredients driving the most interactions

selectively imported Hoodia gordonii 262

Individual Drug Interactions

The ingredients in Hoodia interact with 262 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hoodia interact with drugs. Each result below shows which ingredient is responsible. selectively imported Hoodia gordonii

Each ingredient & the kinds of drugs it affects

For each ingredient in Hoodia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

selectively imported Hoodia gordonii4 drug types · 262 drugs

Antidiabetes Drugs

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. This effect enhances glucose disposal. Theoretically, concomitant use of hoodia with antidiabetes medications may enhance blood glucose-lowering effects and increase the risk of hypoglycemia. Some antidiabetes medications include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Clinical research shows that hoodia can increase blood pressure. Theoretically, concomitant use of hoodia with antihypertensive drugs might decrease the effectiveness of the antihypertensive drugs and increase the risk of hypertension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Beta-Blockers

Evidence from in vitro research shows that hoodia may stimulate beta-adrenergic receptors. Also, clinical research shows that hoodia can increase blood pressure and heart rate. Theoretically, using hoodia with beta-blockers might decrease the effects of these medications. Some beta-blocker drugs include atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal).

Likelihood Possible Evidence D
Insulin

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. Theoretically, concomitant use of hoodia with insulin may enhance the blood glucose-lowering effects of insulin. Blood glucose levels should be monitored.

Likelihood Possible Evidence D
selectively imported Hoodia gordonii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hoodia, from the product label.

L.A. Naturals

See all L.A. Naturals products
Name
Palko Services
Street Address
4991 W. US Hwy 20
City
Michigan City
State
IN
ZipCode
46360
Pharmacist Counseling Corner

Hoodia by L.A. Naturals: Common Questions

Does Hoodia by L.A. Naturals interact with any medications?
Yes. Based on its ingredients, Hoodia has a known interaction with 262 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hoodia contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hoodia, and what is it supposed to do?
Hoodia gordonii is a plant that's been used traditionally as an appetite suppressant. In this product, it's supplied as a liquid extract.
Does this product actually work for weight loss?
The evidence we have doesn't reliably establish that hoodia is effective for obesity. There's insufficient reliable evidence to rate it for weight management.
What side effects has hoodia been reported to cause?
Minor side effects include skin sensation disturbances, headache, dizziness, lightheadedness, and nausea. There's also concern that hoodia may raise blood pressure and heart rate.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe.
Is this product high-quality, or are there quality concerns?
Quality concerns have been reported with hoodia products. The safety data note that limited safety data exist and quality concerns have been noted, so check the brand's sourcing and third-party testing if that matters to you.
Why is there so much interaction data for just one ingredient?
The 262 individual medications span four drug categories — blood pressure drugs, beta-blockers, diabetes medications, and insulin — all of which hoodia may interact with through its effects on blood pressure and blood sugar.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hoodia is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hoodia label
Go deeper

The Full Monographs Behind Hoodia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hoodia

Interacts with 262 drugs

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actually works is lacking. The few quality stud...

Read the full Hoodia monograph →
Sources

Sources & How We Checked

Hoodia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hoodia 3 references
  1. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed
  2. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059.
  3. Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6.

See these in context on the Hoodia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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