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Dietary supplement

Hoodia-Force Oral Spray Ingredients & Drug Interactions

by NewtonEverett

Hoodia-Force Oral Spray label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hoodia-Force Oral Spray against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hoodia-Force Oral Spray is a dietary supplement by NewtonEverett with 1 active ingredient. Its ingredients are commonly taken for appetite suppression, weight loss, reducing food cravings.Based on those ingredients, 262 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hoodia gordonii (aerial parts) 1:4 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hoodia-Force Oral Spray by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Hoodia-Force Oral Spray by NewtonEverett — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hoodia-Force Oral Spray by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Hoodia-Force Oral Spray is a one-ingredient product: hoodia gordonii (aerial parts) in a 1:4 extract form. The liquid formula also contains vegetable glycerin and deionized water as inactive ingredients to deliver the hoodia.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hoodia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: appetite suppression and weight loss support.
  • We looked for evidence on: Obesity, weight management, appetite control.
  • The closest evidence on file: Hoodia is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The effectiveness of hoodia for weight loss is not established in our data — the evidence we have is rated insufficient reliable evidence to rate. That means the studies so far haven't been strong enough to say whether it actually works for obesity.

The evidence, ingredient by ingredient Hoodia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hoodia has limited safety data. Minor side effects reported in people who've taken it include headache, dizziness, nausea, and disturbances in skin sensation.

There's also concern that it may raise blood pressure and heart rate. The safety data advises against use during pregnancy and breastfeeding — there isn't enough information to know it's safe in either situation.

Talk with your doctor or pharmacist before taking it if you're pregnant, planning pregnancy, or breastfeeding.

Side effects, ingredient by ingredient Hoodia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hoodia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before using Hoodia-Force if you take antihypertensive drugs (blood pressure medications), beta-blockers (heart-rate and blood pressure drugs), antidiabetes medications, or insulin. Hoodia may reduce their effectiveness or cause blood sugar to drop too low.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Hoodia-Force is a single-ingredient extract with unclear evidence for weight loss and documented interactions with blood pressure, heart, and diabetes medications. If you take any of those drug types, check with your doctor or pharmacist first — the interaction risk is real.

Even without those medications, the limited safety data means this is worth discussing with your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hoodia-Force Oral Spray, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 818423029085
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 248905
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hoodia-Force Oral Spray by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
818423029085
IngredientAmount% DV
Hoodia gordonii (aerial parts) 1:4 extract0 NP--

Other ingredients: Vegetable Glycerin, deionized Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Holding spray nozzle close to the mouth, spray 6 times into mouth before each meal. This product should be used in conjunction with a sensible diet and exercise program.

Precautions

Warning: This product is not recommended for pregnant or nursing mothers, children under 18 years of age or persons with a known medical condition, including diabetes or hypogycemia.

Warning: This product is not recommended for pregnant or nursing mothers, children under 18 years of age or persons with a known medical condition, including diabetes or hypogycemia.

If you have questions about the advisability of taking this product, consult your physician prior to use.

Keep out of reach of children.

Do not use this product if outer seal is damaged or missing.

Storage

Store in a cool, dry place away from sunlight and moisture.

Formulation

Vegan

Gluten-free Alcohol free

Healthy weight management Oral spray Natural metabolism support

Formula

Natural high potency Hoodia Gordonii extract

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hoodia-Force Oral Spray by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hoodia-Force Oral Spray label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hoodia-Force Oral Spray by NewtonEverett

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Hoodia gordonii (aerial parts) 1:4 extract

Interacts with
262 drugs
0 NP per serving

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actuall...

Hoodia gordonii (aerial parts) 1:4 extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Deionized Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hoodia-Force Oral Spray by NewtonEverett Drug Interactions

Want to check YOUR meds against Hoodia-Force Oral Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
262Drugs
262 Moderate

Ingredients driving the most interactions

Hoodia gordonii (aerial parts) 1:4 extract 262

Individual Drug Interactions

The ingredients in Hoodia-Force Oral Spray interact with 262 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hoodia-Force Oral Spray interact with drugs. Each result below shows which ingredient is responsible. Hoodia gordonii (aerial parts) 1:4 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hoodia-Force Oral Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hoodia gordonii (aerial parts) 1:4 extract4 drug types · 262 drugs

Antidiabetes Drugs

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. This effect enhances glucose disposal. Theoretically, concomitant use of hoodia with antidiabetes medications may enhance blood glucose-lowering effects and increase the risk of hypoglycemia. Some antidiabetes medications include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Clinical research shows that hoodia can increase blood pressure. Theoretically, concomitant use of hoodia with antihypertensive drugs might decrease the effectiveness of the antihypertensive drugs and increase the risk of hypertension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Beta-Blockers

Evidence from in vitro research shows that hoodia may stimulate beta-adrenergic receptors. Also, clinical research shows that hoodia can increase blood pressure and heart rate. Theoretically, using hoodia with beta-blockers might decrease the effects of these medications. Some beta-blocker drugs include atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal).

Likelihood Possible Evidence D
Insulin

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. Theoretically, concomitant use of hoodia with insulin may enhance the blood glucose-lowering effects of insulin. Blood glucose levels should be monitored.

Likelihood Possible Evidence D
Hoodia gordonii (aerial parts) 1:4 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hoodia-Force Oral Spray, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Nutraceuticals
Street Address
PO Box 27793
City
Scottsdale
State
AZ
ZipCode
85255
Phone Number
866.593.3424
Pharmacist Counseling Corner

Hoodia-Force Oral Spray by NewtonEverett: Common Questions

Does Hoodia-Force Oral Spray by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Hoodia-Force Oral Spray has a known interaction with 262 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hoodia-Force Oral Spray contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does hoodia actually help you lose weight?
The evidence we have isn't strong enough to say. Studies so far are rated insufficient reliable evidence to rate, which means we can't confirm that it works for obesity.
What are the side effects of hoodia?
People taking it have reported headache, dizziness, nausea, and skin sensation disturbances. There's also concern that hoodia may raise blood pressure and heart rate.
Can I take hoodia if I'm pregnant or breastfeeding?
No — the safety data advises against it. There isn't enough information to know it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your options.
Can I take this with my diabetes medication?
Not without checking first. Hoodia may boost how much insulin your body makes and lower blood sugar, so combined with your medication it could drop your glucose too low. Your doctor or pharmacist needs to review this before you start.
What's the difference between the spray form and a capsule or tablet?
The spray is a liquid delivery form — the hoodia extract is the same. The spray form uses vegetable glycerin and water, while other forms might use different inactive ingredients, but the active component and its interactions remain the same.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hoodia-Force Oral Spray is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hoodia-Force Oral Spray label
Go deeper

The Full Monographs Behind Hoodia-Force Oral Spray’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hoodia

Interacts with 262 drugs

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actually works is lacking. The few quality stud...

Read the full Hoodia monograph →
Sources

Sources & How We Checked

Hoodia-Force Oral Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hoodia 3 references
  1. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed
  2. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059.
  3. Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6.

See these in context on the Hoodia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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