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Dietary supplement

Hoodia Gordonii Ingredients & Drug Interactions

by Healthy Hope Supplements

Hoodia Gordonii label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hoodia Gordonii against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hoodia Gordonii is a dietary supplement by Healthy Hope Supplements with 1 active ingredient. Its ingredients are commonly taken for appetite suppression, weight loss, reducing food cravings.Based on those ingredients, 262 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hoodia Gordonii. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hoodia Gordonii by Healthy Hope Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Hoodia Gordonii by Healthy Hope Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hoodia Gordonii by Healthy Hope Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Hoodia Gordonii, a succulent plant used as an appetite suppressant. The capsule also contains inactive ingredients—magnesium stearate, stearic acid, methylcellulose, and croscarmellose sodium—which are standard binders and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Hoodia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Boosts energy levels and suppresses appetite.
  • We looked for evidence on: Obesity, Weight management, Appetite control, Energy support, Satiety.
  • The closest evidence on file: Hoodia is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).

The evidence for hoodia's effectiveness against obesity is insufficient. We don't have reliable data showing how well it actually works for weight loss in the facts we hold.

The evidence, ingredient by ingredient Hoodia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hoodia is generally poorly characterized; limited safety data exist and side effects have been reported. Minor adverse effects include skin sensation changes, headache, dizziness, lightheadedness, and nausea.

There's also concern that hoodia may raise blood pressure and heart rate. The safety data advise against use during pregnancy and while breastfeeding due to insufficient information.

Side effects, ingredient by ingredient Hoodia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hoodia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 262 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before starting: blood pressure medications (antihypertensive drugs), beta-blockers for heart or blood pressure, antidiabetes drugs, and insulin. Hoodia may reduce how well your blood pressure or heart medications work and may increase low blood sugar risk with diabetes medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Hoodia Gordonii may appeal to someone looking for an appetite suppressant, but the evidence for it actually working is thin. If you take blood pressure medications, diabetes drugs, insulin, or beta-blockers, you'll want to check with us first—interactions are documented.

Pregnancy and breastfeeding are not recommended.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hoodia Gordonii, straight from the product label.

Brand Healthy Hope Supplements
Market status Off market
Date entered into DSLD May 24, 2013
DSLD ID 21634
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hoodia Gordonii by Healthy Hope Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Hoodia Gordonii1000 mg--

Other ingredients: Magnesium Stearate, Stearic Acid, Methylcellulose, Croscarmellose Sodium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Toll Free!

Boosts Energy Levels Appetite Suppresent

FDA Statement of Identity

Dietary Supplement

Precautions

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING.

CAUTION: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

KEEP OUT OF THE REACH OF CHILDREN.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: For Adults, take two (2) capsules daily, as a dietary supplement.

Storage

STORE IN A COOL, DRY PLACE.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Contains No Sugar, No Starch, No Yeast, No Artificial Colors, Flavors or Preservatives.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hoodia Gordonii by Healthy Hope Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hoodia Gordonii label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hoodia Gordonii by Healthy Hope Supplements

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Hoodia Gordonii

Interacts with
262 drugs
1000 mg per serving

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actuall...

Hoodia Gordonii monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Stearic Acid, Methylcellulose, Croscarmellose Sodium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hoodia Gordonii by Healthy Hope Supplements Drug Interactions

Want to check YOUR meds against Hoodia Gordonii?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
262Drugs
262 Moderate

Ingredients driving the most interactions

Hoodia Gordonii 262

Individual Drug Interactions

The ingredients in Hoodia Gordonii interact with 262 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hoodia Gordonii interact with drugs. Each result below shows which ingredient is responsible. Hoodia Gordonii

Each ingredient & the kinds of drugs it affects

For each ingredient in Hoodia Gordonii with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hoodia Gordonii4 drug types · 262 drugs

Antidiabetes Drugs

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. This effect enhances glucose disposal. Theoretically, concomitant use of hoodia with antidiabetes medications may enhance blood glucose-lowering effects and increase the risk of hypoglycemia. Some antidiabetes medications include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Clinical research shows that hoodia can increase blood pressure. Theoretically, concomitant use of hoodia with antihypertensive drugs might decrease the effectiveness of the antihypertensive drugs and increase the risk of hypertension. Some antihypertensive drugs include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

Likelihood Possible Evidence D
Beta-Blockers

Evidence from in vitro research shows that hoodia may stimulate beta-adrenergic receptors. Also, clinical research shows that hoodia can increase blood pressure and heart rate. Theoretically, using hoodia with beta-blockers might decrease the effects of these medications. Some beta-blocker drugs include atenolol (Tenormin), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal).

Likelihood Possible Evidence D
Insulin

Animal research shows that a steroid glycoside of hoodia, gordonoside F, increases glucose-stimulated insulin secretion by activating GPR119. Theoretically, concomitant use of hoodia with insulin may enhance the blood glucose-lowering effects of insulin. Blood glucose levels should be monitored.

Likelihood Possible Evidence D
Hoodia Gordonii full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hoodia Gordonii, from the product label.

Healthy Hope Supplements

See all Healthy Hope Supplements products
Name
Healthy Hope Supplements
Phone Number
1-877-983-3855
Pharmacist Counseling Corner

Hoodia Gordonii by Healthy Hope Supplements: Common Questions

Does Hoodia Gordonii by Healthy Hope Supplements interact with any medications?
Yes. Based on its ingredients, Hoodia Gordonii has a known interaction with 262 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hoodia Gordonii contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does hoodia actually help you lose weight?
The evidence isn't strong enough to say. The data we have rates its effectiveness as insufficient to rely on for obesity.
What side effects should I watch for?
Minor ones include headache, dizziness, lightheadedness, nausea, and unusual skin sensations. Hoodia may also raise your blood pressure and heart rate, so if you have heart or blood pressure concerns, flag this with your doctor or pharmacist first.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety information, so the data advise against it in both cases. Talk with your pharmacist or doctor about what's right for you.
What exactly is hoodia?
It's a succulent plant used to suppress appetite. This product is just the hoodia itself—one ingredient—plus some inactive capsule fillers.
Why should I be careful if I take blood pressure or diabetes medicine?
Hoodia can raise blood pressure and may boost how much insulin your body releases, both of which can interfere with how well your medications work. Your blood pressure or blood sugar could shift unexpectedly, so you need to discuss this with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hoodia Gordonii label
Go deeper

The Full Monographs Behind Hoodia Gordonii’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hoodia

Interacts with 262 drugs

Hoodia is a succulent plant from southern Africa that is marketed as an appetite suppressant for weight loss, but solid human evidence that it actually works is lacking. The few quality stud...

Read the full Hoodia monograph →
Sources

Sources & How We Checked

Hoodia Gordonii's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hoodia 3 references
  1. Blom WAM, Abrahamse SL, Bradford R, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: a randomized controlled trial. Am J Clin Nutr 2011;94(5) PubMed
  2. Roza O, Lovász N, Zupkó I, Hohmann J, Csupor D. Sympathomimetic activity of a Hoodia gordonii product: a possible mechanism of cardiovascular side effects. Biomed Res Int. 2013;2013:171059.
  3. Zhang S, Ma Y, Li J, et al. Molecular matchmaking between the popular weight-loss herb Hoodia gordonii and GPR119, a potential drug target for metabolic disorder. Proc Natl Acad Sci U S A. 2014;111(40):14571-6.

See these in context on the Hoodia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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