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Dietary supplement

Hops Science Ingredients & Drug Interactions

by ResVitale

Hops Science label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hops Science against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hops Science is a dietary supplement by ResVitale with 1 active ingredient. Its ingredients are commonly taken for sleep problems and insomnia, anxiety and restlessness, menopausal symptoms.Based on those ingredients, 863 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Perluxan(R) Proprietary Hops Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hops Science by ResVitale

Ask about any prescription or over-the-counter medication and we check it for interactions with Hops Science by ResVitale — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hops Science by ResVitale

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

ResVitale Hops Science contains one active ingredient: Perluxan proprietary hops extract. Hops is a plant traditionally used to support relaxation and sleep, though how well it works for these purposes in humans isn't firmly established yet.

The capsule also contains inactive ingredients: a vegetarian capsule shell, rice bran, and silica (a flow agent).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: relief of minor aches and pains.
  • We looked for evidence on: pain, musculoskeletal pain, exercise-induced soreness.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold shows insufficient reliable data to rate hops extract for age-related cognitive decline, sexual dysfunction, anxiety, ADHD, indigestion (dyspepsia), or insomnia. That means studies haven't yet established whether it works for these purposes — it's not that we know it doesn't work, just that the case hasn't been made in the research we have on file.

The evidence, ingredient by ingredient Hops

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hops extract is generally well tolerated in the short term but may cause drowsiness — so avoid driving or operating machinery until you know how it affects you. The safety notes advise against use during pregnancy because there isn't enough safety information.

While breastfeeding, safety is also unknown, so it's best avoided then too. People exposed to hops dust occupationally have reported chronic respiratory symptoms like cough and shortness of breath.

Some postmenopausal women taking supplements containing both hops and soy have experienced abnormal bleeding, though it's unclear whether hops, soy, or the combination caused it. Allergic reactions and contact rash have been reported from touching fresh hops plants and pollen.

Side effects, ingredient by ingredient Hops

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hops.
  • The most serious interaction on file is rated Moderate.
  • For scale: 864 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this with sedatives, sleep aids, or anti-anxiety medications — hops may increase drowsiness. If you take any form of estrogen or hormone replacement therapy, mention this supplement, as hops may interfere.

Additionally, if you take medications processed by your liver (a very broad group), ask whether a hops extract might affect how your body handles them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a single-ingredient hops supplement with limited established evidence for its claimed uses. It's generally well tolerated short-term, but it may make you drowsy and shouldn't be taken during pregnancy or while breastfeeding.

Before starting, check your medications — especially sedatives and hormone therapies — with your doctor or pharmacist, since hops can amplify sedation and theoretically interfere with estrogen replacement.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hops Science, straight from the product label.

Brand ResVitale
Barcode (UPC) 094922380432
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 18017
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hops Science by ResVitale, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
094922380432
IngredientAmount% DV
Perluxan(R) Proprietary Hops Extract500 mg--

Other ingredients: Vegetarian capsule, Rice Bran, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Perluxan(R) is a clinically studied and patented hops extract that is standardized to contain 30% alpha acids, the active compounds that have shown great promise in relieving pain from overexertion.*

Precautions

As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, have existing medical conditions or are taking prescription medications.

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

VL1401

General Statements

For relief of minor aches & pains from every day life*

Co2 Extracted Alpha Acid Complex Natural  GI Friendly* Patented  Scientifically Researched

In a randomized, double-blind, placebo-controlled human study, Perluxan hops extract showed positive improvements in minor pain within just two hours of the first serving.*

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule twice daily for 2 weeks and then 1 capsule daily thereafter. Product can be taken with food or as recommended by your healthcare practitioner.

Formulation

100% Vegetarian

– no artificial colors or flavors.

Does not contain: Corn, soy, wheat, yeast, lactose, citrus, milk, egg or fish products, sugar, salt, starch, artificial coloring, flavoring or preservatives. Gluten free.

Storage

Store tightly in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hops Science by ResVitale label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hops Science label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hops Science by ResVitale

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Perluxan(R) Proprietary Hops Extract

Interacts with
863 drugs
500 mg per serving Form: alpha {acids}, Iso-Alpha Acids

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Perluxan(R) Proprietary Hops Extract monograph & interactions

Other (inactive) ingredients: Vegetarian capsule, Rice Bran, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hops Science by ResVitale Drug Interactions

Want to check YOUR meds against Hops Science?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
863Drugs
289 Moderate 574 Minor

Ingredients driving the most interactions

Perluxan(R) Proprietary Hops Extract 863

Individual Drug Interactions

The ingredients in Hops Science interact with 863 drugs. Click any drug to see the details.

1 of the 1 ingredient in Hops Science interact with drugs. Each result below shows which ingredient is responsible. Perluxan(R) Proprietary Hops Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Hops Science with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Perluxan(R) Proprietary Hops Extract4 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Perluxan(R) Proprietary Hops Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hops Science, from the product label.

ResVitale

See all ResVitale products
Name
RESVITALE
Phone Number
1-877-787-5454
Web Address
www.resvitale.com
Pharmacist Counseling Corner

Hops Science by ResVitale: Common Questions

Does Hops Science by ResVitale interact with any medications?
Yes. Based on its ingredients, Hops Science has a known interaction with 863 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hops Science contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy?
It may — drowsiness is a known side effect. You should avoid driving or using machinery until you see how it affects you personally.
Can I take this if I'm pregnant?
No — there isn't enough safety information, and the data we hold advises against it during pregnancy. Talk with your doctor or pharmacist if you're considering it.
Is it safe to take while breastfeeding?
The safety data advises against it — we don't have enough information to know whether it's safe for your baby. Check with your doctor or pharmacist before use.
Does this actually help with sleep or anxiety?
We don't have reliable evidence to say whether hops works for insomnia or anxiety in humans. The research we hold rates both as insufficient to make that call.
What if I take a sedative medication?
You should check with your doctor or pharmacist first — hops may add to the sedating effect of those drugs and increase drowsiness or impair alertness.
Are there any inactive ingredients I should know about?
The capsule contains rice bran and silica as flow agents, plus a vegetarian capsule shell. If you have sensitivities to any of these, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hops Science label
Go deeper

The Full Monographs Behind Hops Science’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph →
Sources

Sources & How We Checked

Hops Science's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hops 15 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. PubMed
  4. Milligan SR, Kalita JC, Heyerick A, et al. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer. J Clin Endocrinol Metab 1999;84:2249-52.. PubMed
  5. Milligan SR, Kalita JC, Pocock V, et al. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab 2000;85:4912-5.. DOI
  6. Henderson MC, Miranda CL, Stevens JF, et al. In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus. Xenobiotica 2000;30:235-51.. PubMed
  7. Mannering, G. J., Shoeman, J. A., and Deloria, L. B. Identification of the antibiotic hops component, colupulone, as an inducer of hepatic cytochrome P-4503A in the mouse. Drug Metab Dispos 1992;20(2):142-147. DOI
  8. Skorska, C., Mackiewicz, B., Gora, A., Golec, M., and Dutkiewicz, J. Health effects of inhalation exposure to organic dust in hops farmers. Ann.Univ Mariae.Curie Sklodowska [Med] 2003;58(1):459-465.
  9. Schiller, H., Forster, A., Vonhoff, C., Hegger, M., Biller, A., and Winterhoff, H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine. 2006;13(8):535-541. PubMed
  10. van Hunsel, F. P. and Kampschoer, P. [Postmenopausal bleeding and dietary supplements: a possible causal relationship with hop- and soy-containing preparations]. Ned.Tijdschr.Geneeskd. 2012;156(41):A5095.
  11. Fenselau, C. and Talalay, P. Is oestrogenic activity present in hops? Food Cosmet.Toxicol. 1973;11(4):597-602. PubMed
  12. Godnic-Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ilic, Z., and Ebling, Z. Respiratory and immunological findings in brewery workers. Am J Ind Med 1999;35(1):68-75. DOI
  13. Lee KM, Jung JS, Song DK, and et al. Effects of Humulus lupulus extract on the central nervous system in mice. Planta Med 1993;59(Suppl):A691.
  14. Assessment report on Humulus lupulus L., flos. European Medicines Agency, 2014. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-humulus-lupulus-l-flos_en.pdf. Accessed September 29, 2021.
  15. van Breemen RB, Chen L, Tonsing-Carter A, et al. Pharmacokinetic Interactions of a Hop Dietary Supplement with Drug Metabolism in Perimenopausal and Postmenopausal Women. J Agric Food Chem. 2020;68(18):5212-5220. PubMed

See these in context on the Hops monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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