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Dietary supplement

Horny Goat Weed 1000 mg Ingredients & Drug Interactions

by Puritan's Pride

Horny Goat Weed 1000 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horny Goat Weed 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horny Goat Weed 1000 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for erectile dysfunction, low libido, fatigue and low energy.Based on those ingredients, 963 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horny Goat Weed 1000 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Horny Goat Weed 1000 mg by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horny Goat Weed 1000 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: horny goat weed at 1000 mg per capsule. The capsule itself is made from gelatin, cellulose, silica, and magnesium stearate — these are inactive ingredients that help hold the supplement together.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: sexual function and male vitality.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual dysfunction, Male infertility, Fatigue, Libido, Sexual performance — and 1 related terms.
  • The closest evidence on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Sexual dysfunction (Natural Medicines).
  • Also on file: Horny Goat Weed is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Fatigue, Male infertility.

The evidence we hold on horny goat weed isn't established for the conditions it's marketed for. We have insufficient reliable evidence to rate its use for sexual dysfunction, osteoporosis, bronchitis, or coronary heart disease.

If any of those are why you're interested, talk with your pharmacist or doctor about what the actual research shows and whether it's right for you.

The evidence, ingredient by ingredient Horny Goat Weed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of horny goat weed seems to be generally well tolerated, though the safety data overall is limited and product quality can vary. Common side effects include dizziness, dry mouth, nosebleed, thirst, and vomiting.

In rare cases, respiratory arrest has been reported. Long-term use is linked to reports of vomiting, dry mouth, thirst, and nosebleed.

One case report described a man who developed an irregular heartbeat after taking it for 2 weeks, though it's unclear if the product contained only horny goat weed. The safety data advises against use during pregnancy or while breastfeeding.

If you're thinking about this supplement while pregnant or nursing, talk with your doctor or pharmacist about whether it's right for your situation.

Side effects, ingredient by ingredient Horny Goat Weed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horny Goat Weed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 964 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with us or your pharmacist if you're on blood thinners or antiplatelet medications (aspirin, warfarin, clopidogrel), blood pressure drugs, estrogens or hormonal contraceptives, or any medication metabolized by your liver — that's a lot of drugs. The interaction data we hold shows Moderate severity concerns across all of these categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Horny Goat Weed by Puritan's Pride has documented interactions with blood thinners, blood pressure medications, estrogens, and a large number of drugs your liver processes. Before you take it, check your medications with the tool on this page — especially if you're on any prescriptions.

The evidence for what it's marketed to do isn't established, and pregnancy and breastfeeding aren't recommended.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horny Goat Weed 1000 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077518180
Net contents 90 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 286192
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horny Goat Weed 1000 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
025077518180
IngredientAmount% DV
Horny Goat Weed1000 mg--

Other ingredients: Gelatin, Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan's Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 51818 www.puritan.com 1-800-645-1030

Precautions

Warning: This product is intended for use by men and is not intended for use by women.

If you are taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

Brand IP Statement(s)

Copyright 2018 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Formula

Horny Goat Weed 1000 mg per serving

Exotic herb for men

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adult men, take two (2) capsules daily, preferably with a meal.

Formulation

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horny Goat Weed 1000 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horny Goat Weed 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horny Goat Weed 1000 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Horny Goat Weed

Interacts with
963 drugs
1000 mg per serving Form: Epimedium spp.

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...

Horny Goat Weed monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horny Goat Weed 1000 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Horny Goat Weed 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
963Drugs
963 Moderate

Ingredients driving the most interactions

Horny Goat Weed 963

Individual Drug Interactions

The ingredients in Horny Goat Weed 1000 mg interact with 963 drugs. Click any drug to see the details.

1 of the 1 ingredient in Horny Goat Weed 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed

Each ingredient & the kinds of drugs it affects

For each ingredient in Horny Goat Weed 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horny Goat Weed6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Horny Goat Weed full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horny Goat Weed 1000 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Horny Goat Weed 1000 mg by Puritan's Pride: Common Questions

Does Horny Goat Weed 1000 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Horny Goat Weed 1000 mg has a known interaction with 963 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horny Goat Weed 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interact with my birth control?
Yes — horny goat weed has estrogenic activity and can increase estrogen levels in some women, which might strengthen the effects of hormonal birth control. Check your specific pill or patch with the medication tool on this page, and talk with your pharmacist before starting.
Is it safe to use long-term?
The safety data is limited. Short-term use seems to be tolerated by most people, but long-term use is linked to vomiting, dry mouth, thirst, and nosebleed. There's not enough data to say long-term is safe, so talk with your pharmacist about how long you're planning to use it.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it during pregnancy, and there's not enough data to recommend it while breastfeeding. If you're pregnant or nursing and interested in this supplement, talk with your doctor or pharmacist about your options.
What is horny goat weed actually used for?
It's marketed for sexual dysfunction, osteoporosis, bronchitis, and heart disease, but we don't have reliable evidence that it works for any of these. If you're considering it for one of these reasons, ask your pharmacist what the research actually shows.
What are the most common side effects?
Dizziness, dry mouth, nosebleed, thirst, and vomiting are the most common. These are usually mild, but if you're nosebleeding or vomiting, stop and call your doctor or pharmacist.
Will this affect my blood pressure medication?
Possibly — horny goat weed might lower blood pressure on its own, so combining it with blood pressure drugs could increase the risk of blood pressure dropping too low. Check your specific medication with the tool on this page and talk with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horny Goat Weed 1000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horny Goat Weed 1000 mg label
Go deeper

The Full Monographs Behind Horny Goat Weed 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph →
Sources

Sources & How We Checked

Horny Goat Weed 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horny Goat Weed 11 references
  1. Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
  2. Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
  3. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
  4. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
  5. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
  6. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
  7. Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
  8. Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
  9. Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
  10. Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
  11. Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed

See these in context on the Horny Goat Weed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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