Horny Goat Weed with Tongkat Ali & Maca Ingredients & Drug Interactions
by Herbadiet
What is this page for?
First and foremost: checking Horny Goat Weed with Tongkat Ali & Maca against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Horny Goat Weed with Tongkat Ali & Maca is a dietary supplement by Herbadiet with 3 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 988 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horny Goat Weed Extract, Tongkat Ali root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Horny Goat Weed with Tongkat Ali & Maca by Herbadiet
Ask about any prescription or over-the-counter medication and we check it for interactions with Horny Goat Weed with Tongkat Ali & Maca by Herbadiet — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Horny Goat Weed with Tongkat Ali & Maca by Herbadiet
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains three active ingredients: tongkat Ali root extract, maca root extract, and horny goat weed extract. Tongkat Ali has been studied for sexual desire and testosterone support.
Maca is traditionally used for sexual function and general vitality. Horny goat weed has a long history in herbal medicine for similar purposes.
The capsule itself is made with vegetable cellulose as an inactive ingredient.
Does it work?
Moderate evidence
The evidence for this combination is limited. Tongkat Ali is rated possibly effective for sexual desire based on available research.
Horny goat weed and maca are both rated as having insufficient reliable evidence in the data we hold—meaning their effectiveness for sexual function or other purposes has not been established in studies we can point to. Claims about athletic performance, bone health, and other conditions lack sufficient evidence to support them.
How safe is it?
Well-documented data
Short-term use of these ingredients is generally well tolerated in the studies we have, but long-term safety is uncertain and product quality can vary. Horny goat weed may cause dizziness, dry mouth, nosebleed, thirst, or vomiting in some people; long-term use has been linked to reports of similar effects.
Tongkat Ali raises testosterone levels in some men, which could theoretically lead to acne, insulin resistance, or liver problems if levels go too high. Maca may cause stomach pain if it's uncooked or fresh.
All three ingredients lack sufficient safety data in pregnancy and should be avoided; horny goat weed is specifically rated possibly unsafe in pregnancy. Breastfeeding is not recommended with any of these ingredients due to insufficient data.
Meds to double-check
Moderate interaction found
Check these medication types before taking this product: blood pressure medications (antihypertensives)—horny goat weed may lower pressure too far; blood thinners and antiplatelet drugs like warfarin or aspirin—increased bleeding risk; hormone therapies, especially estrogens; beta-blockers like propranolol; and any drug metabolized by liver enzymes CYP1A2, CYP2B6, or CYP3A4, which this product may inhibit. If you're on any regular prescription medication, run it through the search tool on this page.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is geared toward sexual function and vitality, but evidence for its effectiveness is weak or absent in our data. If you take blood pressure medications, blood thinners, hormone therapies, or any prescription drug metabolized by your liver, you'll want to check with your pharmacist before starting.
Pregnancy and breastfeeding are not safe times to use it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Horny Goat Weed with Tongkat Ali & Maca, straight from the product label.
| Brand | Herbadiet |
|---|---|
| Barcode (UPC) | 880208065298 |
| Net contents | 60 V-Cap(s) |
| Market status | On market |
| Date entered into DSLD | Nov 19, 2021 |
| DSLD ID | 257680 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Horny Goat Weed with Tongkat Ali & Maca by Herbadiet, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Tongkat Ali root extract | 100 mg | -- |
| Maca root extract | 100 mg | -- |
| Horny Goat Weed Extract | 150 mg | -- |
Other ingredients: Vegetable Cellulose Shell
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
This blend is a mix of high potency standardized extract of 3 carefully selected powerful herbs. This full spectrum extract blend retains all the active constituents in nature intended balanced ratio. Encapsulating this goodness in our quick release, easy to swallow vegan capsules, guarantees you a premium quality nutritional supplement.
Boost libido & testosterone Supports blood flow Sexual wellness
Natural color variation may occur in this product
100% natural Sexual wellness
Non-GMO
Suitable for vegetarians and vegans
Free of preservatives, binders, gluten, artificial ingredients, dairy, soy, wheat, yeast
Every batch 3rd party lab tested
FDA Disclaimer Statement
These statements have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Do not use if seal under the cap is broken or missing. Dietary supplement shouldn't be used as a substitute for a varied diet
Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Not for medicinal use
Storage
Store in cool, dry place
Seals/Symbols
fssai Lic. No.: 20817018000147 Vcaps Plus GMP Good Manufacturing Practice Quality Product
General Statements
1% for the planet
License Number : 10018064001315
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for Use: Take 1 capsule twice a day preferably with meals or as directed by your physician.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Horny Goat Weed with Tongkat Ali & Maca by Herbadiet label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Horny Goat Weed with Tongkat Ali & Maca by Herbadiet
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Tongkat Ali root extract
Interacts with248 drugs
Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...
Tongkat Ali root extract monograph & interactionsMaca root extract
No knowninteractions
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...
Maca root extract monograph & interactionsHorny Goat Weed Extract
Interacts with963 drugs
Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these...
Horny Goat Weed Extract monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Shell. These complete the product’s ingredient list but are not active constituents.
Horny Goat Weed with Tongkat Ali & Maca by Herbadiet Drug Interactions
HelloPharmacist Interaction Report
Horny Goat Weed with Tongkat Ali & Maca by Herbadiet has documented interactions with a substantial number of medications.
The most serious concern is with blood pressure medications (antihypertensives): horny goat weed may lower blood pressure further, creating a theoretical risk of dangerously low blood pressure. A second major concern involves blood thinners and antiplatelet drugs (like aspirin or warfarin)—horny goat weed may increase bleeding risk based on lab and animal data, though this hasn't been confirmed in humans.
Read the full breakdown — every affected drug type, severity by severity
Tongkat Ali can reduce levels of propranolol (a beta-blocker used for heart disease and high blood pressure), potentially lowering its effectiveness; a clinical study showed a 29% drop in propranolol levels. Additionally, horny goat weed may increase the effects of several liver enzymes that metabolize many medications, including CYP1A2, CYP2B6, and CYP3A4 substrates—this could amplify both therapeutic and side effects of those drugs.
Tongkat Ali has similar weak enzyme effects in vitro. Horny goat weed also carries a theoretical risk of increasing estrogen levels in some people, which could interact with hormone therapies.
Maca root extract has no documented interactions in our data. Altogether, these interactions span 977 individual medications.
Check your specific prescriptions and supplements with the search tool on this page before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Horny Goat Weed with Tongkat Ali & Maca?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Horny Goat Weed with Tongkat Ali & Maca interact with 988 drugs. Click any drug to see the details.
2 of the 3 ingredients in Horny Goat Weed with Tongkat Ali & Maca interact with drugs. Each result below shows which ingredient is responsible. Horny Goat Weed Extract Tongkat Ali root extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed Extract + Abrocitinib interactionTongkat Ali Root ExtractCytochrome P450 2c19 (cyp2c19) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
Read the full Tongkat Ali Root Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acalabrutinib interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of hypotension.
Read the full Horny Goat Weed Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Horny Goat Weed with Tongkat Ali & Maca — through 1 ingredient. Tap an ingredient for the detail:
Horny Goat Weed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Aspirin interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, horny goat weed might increase the risk of bleeding.
Read the full Horny Goat Weed Extract + Acetaminophen, Aspirin, Caffeine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Butalbital interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Butalbital, Caffeine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Butalbital, Codeine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Caffeine, Codeine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Caffeine, Isometheptene interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Caffeine, Pyrilamine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Horny Goat Weed with Tongkat Ali & Maca — through 2 ingredients. Tap an ingredient for the detail:
Horny Goat Weed ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
Read the full Horny Goat Weed Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionTongkat Ali Root ExtractCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
Read the full Tongkat Ali Root Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Horny Goat Weed with Tongkat Ali & Maca with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Horny Goat Weed Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.
Antihypertensive Drugs
Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.
Tongkat Ali root extract
Propranolol (Inderal)
Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.
Cytochrome P450 2A6 (Cyp2A6) Substrates
Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.
Testosterone
Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.
Brand information
Manufacturer and brand details for Horny Goat Weed with Tongkat Ali & Maca, from the product label.
Herbadiet
See all Herbadiet products- Name
- Arkure Health Care
- City
- Haryana
- State
- India
- Web Address
- www.herbadiet.in
Horny Goat Weed with Tongkat Ali & Maca by Herbadiet: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Horny Goat Weed with Tongkat Ali & Maca’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Eurycoma Longifolia
Interacts with 248 drugsEurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....
Read the full Eurycoma Longifolia monograph → Herb & supplement monographMaca
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...
Read the full Maca monograph → Herb & supplement monographHorny Goat Weed
Interacts with 963 drugsHorny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...
Read the full Horny Goat Weed monograph →Sources & How We Checked
Horny Goat Weed with Tongkat Ali & Maca's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 16 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Eurycoma Longifolia 4 references
- Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
- Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
- Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
- Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent
Maca 1 reference
- Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed
Horny Goat Weed 11 references
- Cirigliano MD, Szapary PO. Horny goat weed for erectile dysfunction. Alt Med Alert 2001;4:19-22.
- Partin JF, Pushkin YR. Tachyarrhythmia and hypomania with horny goat weed. Psychosomatics 2004;45:536-7. PubMed
- De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. PubMed
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
- Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. PubMed
- Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. PubMed
- Ramanathan VS, Mitropoulos E, Shlopov B, et al. An Enzyte'ing' case of acute hepatitis. J Clin Gastroenterol 2011;45(9):834-5. PubMed
- Zhong Q, Shi Z, Zhang L, et al. The potential of Epimedium koreanum Nakai for herb-drug interaction. J Pharm Pharmacol 2017;69(10):1398-408. doi: 10.1111/jphp.12773.
- Irfan M, Kwon TH, Lee DH, et al. Antiplatelet and Antithrombotic Effects of Epimedium koreanum Nakai. Evid Based Complement Alternat Med. Apr 2021;2021:7071987. PubMed
- Tan K, Yang W, Pang L, Hou F. Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury. Medicine (Baltimore) 2022;101(32):e29909. PubMed
- Li K, Yu XH, Maskey AR, et al. Cytochrome P450 3A4 suppression by epimedium and active compound kaempferol leads to synergistic anti-inflammatory effect with corticosteroid. Front Pharmacol 2023;13:1042756. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC