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Dietary supplement

Horsechestnut Extract 300 mg Ingredients & Drug Interactions

by Vital Nutrients

Horsechestnut Extract 300 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Horsechestnut Extract 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Horsechestnut Extract 300 mg is a dietary supplement by Vital Nutrients with 1 active ingredient. Its ingredients are commonly taken for chronic venous insufficiency, leg swelling and heaviness, varicose veins.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Horsechestnut seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Horsechestnut Extract 300 mg by Vital Nutrients

Ask about any prescription or over-the-counter medication and we check it for interactions with Horsechestnut Extract 300 mg by Vital Nutrients — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Horsechestnut Extract 300 mg by Vital Nutrients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: horsechestnut seed extract at 300 mg per capsule. The extract is used in traditional practice for circulation and vein health, specifically for the leg swelling and discomfort tied to chronic venous insufficiency.

The inactive ingredients are vegetable cellulose (the capsule itself), cellulose, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: leg and vascular circulation support.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Hemorrhoids, Postoperative swelling, varicose veins, leg edema.
  • The strongest evidence on file: Horse Chestnut is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Horse Chestnut is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Postoperative swelling.

Horsechestnut seed extract is possibly effective for chronic venous insufficiency—the condition where your veins don't pump blood back up from your legs as well as they should, causing swelling and heaviness. For other uses listed here (hemorrhoids, irritable bowel syndrome, kidney stones), there isn't enough reliable evidence to say whether it works or not.

The evidence, ingredient by ingredient Horse Chestnut

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The processed seed extract in this product is generally well tolerated by mouth. The most common side effects reported in people taking it are dizziness, upset stomach, headache, and itching.

One rare case of heart inflammation has been reported, possibly linked to the extract's blood-thinning action or an immune response—this is not common. You should avoid this product during pregnancy and while breastfeeding; there isn't enough safety information to recommend it in either situation.

Raw horsechestnut plant parts are toxic and should never be used.

Side effects, ingredient by ingredient Horse Chestnut

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Horse Chestnut.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, confirm with your doctor or pharmacist that it's safe to combine with any blood thinners or antiplatelet drugs you're on—that includes prescription blood thinners like warfarin, as well as aspirin and other similar medications. The extract may increase bleeding risk when used together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you have leg swelling from poor circulation and you're looking for a natural option—the evidence suggests it could help. If you take any blood thinner or antiplatelet medication, check with your doctor or pharmacist first.

Talk it over with your healthcare provider before starting, especially if you're pregnant, nursing, or on any medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Horsechestnut Extract 300 mg, straight from the product label.

Brand Vital Nutrients
Barcode (UPC) 693465222119
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182367
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Horsechestnut Extract 300 mg by Vital Nutrients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
45
UPC/BARCODE
693465222119
IngredientAmount% DV
Horsechestnut seed extract600 mg--

Other ingredients: Vegetable Cellulose Capsule, Cellulose, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store sealed in a cool dry place

Precautions

Keep out of reach of children

Use only if safety seal is intact

Warning If pregnant, consult your physician before taking.

Suggested/Recommended/Usage/Directions

Recommendations 1 to 2 capsules 1 to 2 times daily, or as directed by your healthcare professional.

Formulation

Excludes coatings, binders, gluten (wheat, rye, barley), milk/dairy (casein, whey), soy protein, egg protein, sugar.

General Statements

Verified by independent testing

Raw materials and finished products are independently tested by U.S. labs.

FDA Statement of Identity

Dietary Supplement

General

REV. 1017

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Horsechestnut Extract 300 mg by Vital Nutrients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Horsechestnut Extract 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Horsechestnut Extract 300 mg by Vital Nutrients

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Horsechestnut seed extract

Interacts with
122 drugs
600 mg per serving

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and h...

Horsechestnut seed extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule, Cellulose, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Horsechestnut Extract 300 mg by Vital Nutrients Drug Interactions

Want to check YOUR meds against Horsechestnut Extract 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Horsechestnut seed extract 122

Individual Drug Interactions

The ingredients in Horsechestnut Extract 300 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Horsechestnut Extract 300 mg interact with drugs. Each result below shows which ingredient is responsible. Horsechestnut seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Horsechestnut Extract 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Horsechestnut seed extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Horse chestnut may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Horse chestnut contains the constituent esculin which has been shown to have antithrombotic effects. Therefore, horse chestnut might have antiplatelet effects. This has not been shown in humans.

Likelihood Possible Evidence D
Horsechestnut seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Horsechestnut Extract 300 mg, from the product label.

Vital Nutrients

See all Vital Nutrients products
Name
Vital Nutrients
Street Address
45 Kenneth Dooley Dr
City
Middletown
State
CT
ZipCode
06457
Web Address
vitalnutrients.net
Pharmacist Counseling Corner

Horsechestnut Extract 300 mg by Vital Nutrients: Common Questions

Does Horsechestnut Extract 300 mg by Vital Nutrients interact with any medications?
Yes. Based on its ingredients, Horsechestnut Extract 300 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Horsechestnut Extract 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on aspirin?
Not without checking first. Horsechestnut extract can thin the blood, and aspirin does too, so together they could raise your bleeding risk. Talk to your doctor or pharmacist about whether it's safe for you.
What are the most common side effects?
Dizziness, stomach upset, headache, and itching are the side effects most often reported. Most people tolerate the processed extract well, but not everyone.
Is this safe if I'm pregnant or breastfeeding?
No. There isn't enough safety information, so it's best avoided during pregnancy and while breastfeeding. Talk to your doctor about other options if you need help with circulation during this time.
Does horsechestnut actually work for leg swelling?
The evidence suggests it's possibly effective for chronic venous insufficiency—the kind of leg swelling and heaviness that comes from poor circulation. It's not a guaranteed fix, but the research is encouraging enough that it's worth trying if your doctor agrees it's right for you.
What exactly does this extract do?
Horsechestnut seed extract is used to support your veins and circulation, particularly to ease the swelling, heaviness, and discomfort in your legs caused by poor blood flow back up from your lower legs.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Horsechestnut Extract 300 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Horsechestnut Extract 300 mg label
Go deeper

The Full Monographs Behind Horsechestnut Extract 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Horse Chestnut

Interacts with 122 drugs

Horse chestnut seed extract is most often used for chronic venous insufficiency, where standardized products may help reduce leg swelling, pain, and heaviness. Raw, unprocessed horse chestnu...

Read the full Horse Chestnut monograph →
Sources

Sources & How We Checked

Horsechestnut Extract 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Horse Chestnut 21 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  5. Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
  6. Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
  7. Takegoshi K, Tohyama T, Okuda K, et al. A case of Venoplant-induced hepatic injury. Gastroenterol Jpn 1986;21:62-5.
  8. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98.
  9. Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
  10. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  11. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13. PubMed
  12. Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1. PubMed
  13. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd. PubMed
  14. Ottillinger, B. and Greeske, K. Rational therapy of chronic venous insufficiency--chances and limits of the therapeutic use of horse-chestnut seeds extract. BMC.Cardiovasc.Disord. 2001;1(1):5. PubMed
  15. Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev. 2004;(2):CD003230. PubMed
  16. Fang, Y., Zhao, L., Yan, F., Xia, X., Xu, D., and Cui, X. Escin improves sperm quality in male patients with varicocele-associated infertility. Phytomedicine. 2010;17(3-4):192-196. PubMed
  17. De Smet, P. A., Van den Eertwegh, A. J., Lesterhuis, W., and Stricker, B. H. Hepatotoxicity associated with herbal tablets. BMJ 7-13-1996;313(7049):92.
  18. Rehn, D., Unkauf, M., Klein, P., Jost, V., and Lucker, P. W. Comparative clinical efficacy and tolerability of oxerutins and horse chestnut extract in patients with chronic venous insufficiency. Arzneimittelforschung 1996;46(5):483-487.
  19. Edem E, Kahyaoglu B, Çakar MA. Acute Effusive Pericarditis due to Horse Chestnut Consumption. Am J Case Rep. 2016;17:305-8. PubMed
  20. Costa Santos D, Lérias G, Madruga I. Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement. Eur J Case Rep Intern Med 2021;8(3):002389. PubMed
  21. Yi HY, Lee JY. Poisoning due to consumption of horse chestnut seed. Clin Exp Emerg Med 2021;8(4):333-335. PubMed

See these in context on the Horse Chestnut monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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