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Dietary supplement

Huperzine A 400 mcg Ingredients & Drug Interactions

by NusaPure

Huperzine A 400 mcg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Huperzine A 400 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Huperzine A 400 mcg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, alzheimer's disease and dementia, age-related memory decline.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Huperzine A 400 mcg by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Huperzine A 400 mcg by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Huperzine A 400 mcg by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: huperzine A at 400 micrograms per capsule. Huperzine A is an alkaloid compound extracted from club moss that works by blocking an enzyme called acetylcholinesterase — essentially letting the brain chemical acetylcholine stick around longer.

The inactive ingredients are cellulose, silica, magnesium stearate, and rice flour, which are standard capsule fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Huperzine A's overall clinical evidence instead.

Moderate

Some clinical evidence supports Huperzine A for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

Huperzine A is rated possibly effective for Alzheimer disease based on available evidence. For athletic performance, cognitive impairment, vascular dementia, depression, and memory, the evidence isn't established — the data we hold shows insufficient reliable evidence to rate it.

If you're considering this supplement for one of those other uses, talk with your doctor about what the research actually shows and whether it makes sense for your situation.

The evidence, ingredient by ingredient Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, huperzine A is generally well tolerated, though it is a pharmacologically active compound and you should use it with care and medical guidance. The most common side effects are dose-dependent and stem from how it boosts acetylcholine — blurred vision, constipation, diarrhea, dizziness, dry mouth, insomnia, nausea, sweating, and vomiting.

A few cases of slowed heart rate have been reported, and in rare historical cases of accidental poisoning, people developed high blood pressure. There isn't enough safety data to recommend huperzine A during pregnancy or while breastfeeding, so avoid it in those situations.

Side effects, ingredient by ingredient Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Huperzine A.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking huperzine A, check whether you're on any cholinergic drugs (such as medications for myasthenia gravis or glaucoma) or anticholinergic drugs (such as treatments for overactive bladder or Parkinson's disease). Both interactions are moderate in severity and need your doctor's or pharmacist's input.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Huperzine A may be worth considering if you're dealing with Alzheimer disease and your doctor thinks it's appropriate. But because it interacts with both cholinergic and anticholinergic medications — a combined 219 drugs across both categories — check your exact prescriptions before you start.

Pregnancy and breastfeeding are off-limits given the safety data. Talk it over with your doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Huperzine A 400 mcg, straight from the product label.

Brand NusaPure
Barcode (UPC) X001O6GNUB
Net contents 180 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307333
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Huperzine A 400 mcg by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
90
UPC/BARCODE
X001O6GNUB
IngredientAmount% DV
Huperzine A400 mcg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

From Huperzina serrata plant

Huperzine A 400 mcg per serving

General Statements

New

Please recycle

Precautions

Warning: For adults only. Keep out of reach of children.

Do not use this product if you are pregnant, may become pregnant, are breastfeeding, or if you suffer from irregular heart rhythm (e.g. atrial fibrillation) and congestive heart failure. Consult your doctor before using if you are currently taking any anticholinergic drugs, acetylcholinesterase inhibitors, or cholinergic drugs.

Discontinue use or reduce dosage if the following symptoms develop: Nausea, vomiting, diarrhea, incontinence, or muscle twitches. Huperzine A can cause gastrointestinal discomfort for some individuals. Do not exceed recommended dose. Do not eat freshness packet. Keep in bottle.

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool, dry place after opening.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium quality Assembled in USA GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Manufactured in a cGMP inspected facility

Formulation

GMO free Made with Non-GMO ingredients Gluten free FDA Registered Facility

Assembled in USA Tested Supports normals nutritional supplementation Made under strict GMP guidelines Max strength

Suitable for vegetarians/vegans

Allergen information: Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Huperzine A 400 mcg by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Huperzine A 400 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Huperzine A 400 mcg by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Huperzine A

Interacts with
219 drugs
400 mcg per serving Form: Huperzia serrata

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Huperzine A 400 mcg by NusaPure Drug Interactions

Want to check YOUR meds against Huperzine A 400 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Huperzine A 219

Individual Drug Interactions

The ingredients in Huperzine A 400 mcg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Huperzine A 400 mcg interact with drugs. Each result below shows which ingredient is responsible. Huperzine A

Each ingredient & the kinds of drugs it affects

For each ingredient in Huperzine A 400 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Huperzine A 400 mcg, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central, LLC
Street Address
500 Westover Dr. #92909
City
Sanford
State
NC
ZipCode
27330
Pharmacist Counseling Corner

Huperzine A 400 mcg by NusaPure: Common Questions

Does Huperzine A 400 mcg by NusaPure interact with any medications?
Yes. Based on its ingredients, Huperzine A 400 mcg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Huperzine A 400 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is huperzine A safe to take while I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided then. Safety while breastfeeding is unknown as well, so avoid it in that situation too. Talk with your doctor or pharmacist before taking any supplement while pregnant or nursing.
What are the most common side effects?
Dose-dependent side effects from boosting acetylcholine include blurred vision, constipation, diarrhea, dizziness, dry mouth, insomnia, nausea, sweating, and vomiting. Slowed heart rate has also been reported in a few cases.
Does it actually work for memory and cognitive impairment?
The evidence isn't established in our data. Huperzine A is possibly effective for Alzheimer disease, but for memory, cognitive impairment, and other uses, there's insufficient reliable evidence to rate it. Your doctor can tell you more about what research shows for your specific situation.
What is huperzine A and how does it work?
It's an alkaloid compound from club moss that blocks an enzyme called acetylcholinesterase. This lets acetylcholine, a brain chemical important for memory and thinking, stay active longer.
Can I take this with my glaucoma medication?
That depends on which glaucoma medication you're on — some are cholinergic drugs that work similarly to huperzine A, which could cause a buildup of effects. Don't guess; check with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Huperzine A 400 mcg label
Go deeper

The Full Monographs Behind Huperzine A 400 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Huperzine A 400 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Huperzine A 13 references
  1. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
  3. Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
  4. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
  5. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  6. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
  7. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
  8. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
  13. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed

See these in context on the Huperzine A monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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