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Dietary supplement

Polypodium Ingredients & Drug Interactions

by NusaPure

Polypodium label
See full label image
Capsule Category: Botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Polypodium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Polypodium is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for sun sensitivity and sunburn protection, skin conditions like vitiligo and melasma, polymorphic light eruption.Based on those ingredients, 643 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Polypodium leucotomos. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Polypodium by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Polypodium by NusaPure — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Polypodium by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Polypodium leucotomos, a fern extract. The capsule also holds inactive ingredients — cellulose, silica, magnesium stearate, and rice flour — which are fillers and binders that help form and preserve the supplement.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Polypodium Leucotomos product and its label doesn't state a use — see Polypodium Leucotomos's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on Polypodium leucotomos doesn't establish that it works for dementia, atopic dermatitis (eczema), actinic keratoses, cutaneous lupus erythematosus (CLE), or psoralen-UVA photodamage. The data we have rates all these uses as having insufficient reliable evidence.

If you're considering this supplement for a specific condition, talk with your doctor about what the current science actually supports.

The evidence, ingredient by ingredient Polypodium Leucotomos

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Polypodium leucotomos is generally well tolerated in studies, but long-term safety hasn't been thoroughly established, so there are limits to what we know about taking it for months or years. Itching (pruritus) has rarely been reported.

Because there isn't enough safety data during pregnancy, the safety data advises against use if you're pregnant. Safety while breastfeeding is unknown, so avoiding it is the safer choice if you're nursing.

Side effects, ingredient by ingredient Polypodium Leucotomos

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Polypodium Leucotomos.
  • The most serious interaction on file is rated Minor.
  • For scale: 644 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, have your pharmacist or doctor check whether you take any medications that are broken down by your liver's CYP3A4 enzyme — a large group that includes many blood pressure drugs, statins, sedatives, and immunosuppressants. The interaction is rated Minor, but because it affects so many different medication types, it's worth confirming your specific drugs are in the clear.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

NusaPure Polypodium is a single-ingredient supplement whose effectiveness for its proposed uses hasn't been established in the data we hold. Its main caution is a Minor interaction with hundreds of medications that your liver processes through the CYP3A4 pathway.

If you take any prescription or over-the-counter drugs, check them against the interaction tool on this page, and talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Polypodium, straight from the product label.

Brand NusaPure
Barcode (UPC) X001O7H8N1
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 274969
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Polypodium by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
200
UPC/BARCODE
X001O7H8N1
IngredientAmount% DV
Polypodium leucotomos240 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule 1-2 times daily with food, or as recommended by your healthcare practitioner.

Precautions

Warning: If you are pregnant, nursing or taking medications, consult with your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Allergen Information: Contains no artificial coloring, artificial flavors, preservatives, sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Natural color variation may occur in this product.

Made with non-GMO ingredients GMO free FDA registered facility gluten free

Assembled in USA Natural Supports healthy skin immunity Supports normal antioxidant activity Supports healthy immune function Max strength

Allergen Information: Contains no artificial coloring, artificial flavors, preservatives, sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, fish, shellfish or tree nut ingredients.

Storage

Store in cool dry place. Avoid excessive heat or moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA

Manufactured in a cGMP Inspected Facility

Formula

Polypodium 2400 mg equivalent per capsule

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Polypodium by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Polypodium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Polypodium by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container200 Amounts shown are per serving.

Polypodium leucotomos

Interacts with
643 drugs
240 mg per serving

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-trigger...

Polypodium leucotomos monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Polypodium by NusaPure Drug Interactions

Want to check YOUR meds against Polypodium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
643Drugs
643 Minor

Ingredients driving the most interactions

Polypodium leucotomos 643

Individual Drug Interactions

The ingredients in Polypodium interact with 643 drugs. Click any drug to see the details.

1 of the 1 ingredient in Polypodium interact with drugs. Each result below shows which ingredient is responsible. Polypodium leucotomos

Each ingredient & the kinds of drugs it affects

For each ingredient in Polypodium with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Polypodium leucotomos1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Polypodium leucotomos might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggests that Polypodium leucotomos can decrease the metabolism of midazolam by a mechanism possibly related to the inhibition of CYP3A4. However, a small study in humans suggests that taking Polypodium leucotomos with midazolam does not affect the metabolism of midazolam.

Likelihood Unlikely Evidence B
Polypodium leucotomos full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Polypodium, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central LLC
Street Address
4700 Millenia Boulevard, Suite 175 PMB 92909
City
Orlando
State
FL
ZipCode
32839
Pharmacist Counseling Corner

Polypodium by NusaPure: Common Questions

Does Polypodium by NusaPure interact with any medications?
Yes. Based on its ingredients, Polypodium has a known interaction with 643 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Polypodium contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Polypodium leucotomos?
It's an extract from a tropical fern. In the supplement, it's the only active ingredient; the rest are inactive fillers and binders.
Can I take this while I'm pregnant?
No. There isn't enough safety data during pregnancy, so the safety data advises against it. If you're pregnant or planning to be, talk with your doctor or pharmacist before taking this product.
Is it safe to breastfeed while taking Polypodium leucotomos?
Safety while breastfeeding is unknown. Because we don't have enough data, avoiding this supplement is the safer choice if you're nursing. Talk with your doctor or pharmacist if you have questions.
What side effects has it caused?
In studies, it's generally been well tolerated. Itching (pruritus) has rarely been reported. Long-term safety data is limited, so we don't know what effects might show up with extended use.
Does this supplement actually work for skin conditions or dementia?
The evidence we have doesn't establish that it works for those uses — dementia, eczema, actinic keratoses, cutaneous lupus, or photodamage all rate as having insufficient reliable evidence. If you're considering it for a specific health goal, check with your doctor about what's proven.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Polypodium is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Polypodium label
Go deeper

The Full Monographs Behind Polypodium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Polypodium Leucotomos

Interacts with 643 drugs

Polypodium leucotomos is a fern extract taken by mouth, mostly studied as an add-on to (not a replacement for) sunscreen and for certain light-triggered skin conditions. Some early research...

Read the full Polypodium Leucotomos monograph →
Sources

Sources & How We Checked

Polypodium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Polypodium Leucotomos 2 references
  1. Goh CL, Chuah SY, Tien S, Thng G, Vitale MA, Delgado-Rubin A. Double-blind, placebo-controlled trial to evaluate the effectiveness of Polypodium leucotomos extract in the treatment of melasma in Asian skin: a pilot study. J Clin Aesthet Dermatol 2018;11(3
  2. Shinya K, Nishimura Y, Ryu K, et al. Short-term administration of Polypodium leucotomos extract does not inhibit CYP3A4-mediated metabolism of midazolam in healthy subjects: an open-label, two-period, fixed-sequence study. Int J Dermatol 2022.

See these in context on the Polypodium Leucotomos monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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