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Dietary supplement

Huperzine-A Ingredients & Drug Interactions

by Absonutrix

Huperzine-A label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Huperzine-A against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Huperzine-A is a dietary supplement by Absonutrix with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, alzheimer's disease and dementia, age-related memory decline.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Huperzine A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Huperzine-A by Absonutrix

Ask about any prescription or over-the-counter medication and we check it for interactions with Huperzine-A by Absonutrix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Huperzine-A by Absonutrix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.
  • “Huperzine A” is listed as a grouped ingredient — the label gives one combined amount (400 mcg) without saying how much of each component you get.

This liquid contains one active ingredient: huperzia serrata whole herb extract, a plant source of huperzine A. Huperzine A is an alkaloid compound that works by inhibiting acetylcholinesterase, an enzyme that breaks down acetylcholine — a neurotransmitter involved in memory and cognitive function.

The product also contains inactive ingredients (water, ethanol, potassium sorbate, stevia, and peppermint oil) that serve as the liquid base, preservative, sweetener, and flavoring.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Toothed Clubmoss product and its label doesn't state a use — see Toothed Clubmoss's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

Our data on file does not include an effectiveness rating for huperzia serrata whole herb extract or huperzine A. We cannot tell you whether this product is established to work for memory, cognition, or any other purpose based on the information we hold.

The evidence, ingredient by ingredient Huperzine A Toothed Clubmoss

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Huperzine A can cause dizziness, nausea, and sweating when taken by mouth. The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe at those times.

Additionally, product quality varies widely in this category, so consistency between batches may differ. A thorough safety evaluation hasn't been conducted, so side effects beyond those reported may exist.

Side effects, ingredient by ingredient Huperzine A Toothed Clubmoss

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Toothed Clubmoss.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take cholinergic drugs like donepezil (Aricept) or bethanechol (Urecholine), or anticholinergic drugs — both carry Moderate interaction risk. Use the medication checker on this page to verify your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in huperzine A for memory or cognitive support, talk with your pharmacist first — especially if you take any medications that affect acetylcholine activity (cholinergic or anticholinergic drugs). The safety data advises against it in pregnancy and while breastfeeding.

Make sure to check your exact medications before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Huperzine-A, straight from the product label.

Brand Absonutrix
Barcode (UPC) 685167904929
Net contents 4 Fluid Ounce(s); 118 mL
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 322356
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Huperzine-A by Absonutrix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.59 mL
Maximum serving Sizes:
0.59 mL
Servings per container
200
UPC/BARCODE
685167904929
IngredientAmount% DV
Huperzine A400 mcg--
Huperzia serrata Whole Herb Extract0 NP--

Other ingredients: Water, Distilled, Ethanol, Potassium Sorbate, Stevia, Peppermint Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake well before use. Take 12 drops once daily. Hold in mouth for 15 seconds and then swallow. If supplement flavour is too strong, add it into a preferred drink like water or juice and consume.

Precautions

Caution: for adults only. Keep out of reach of children.

Consult a physician if you are pregnant/nursing, taking any medications, or have a medical condition.

In the unlikely event that you do experience any side effects or allergies, stop use immediately and promptly seek medical attention.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Liquid supplement

Highest quality ingredients Powerful formula Made in USA

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made in USA

General Statements

Please recycle

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Huperzine-A by Absonutrix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Huperzine-A label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Huperzine-A by Absonutrix

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.59 mL Dosage formLiquid Servings per container200 Amounts shown are per serving.

Huperzine A

Interacts with
219 drugs
400 mcg per serving

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine A monograph & interactions

Other (inactive) ingredients: Water, Distilled, Ethanol, Potassium Sorbate, Stevia, Peppermint Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Huperzine-A by Absonutrix Drug Interactions

Want to check YOUR meds against Huperzine-A?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Huperzine A 219

Individual Drug Interactions

The ingredients in Huperzine-A interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Huperzine-A interact with drugs. Each result below shows which ingredient is responsible. Huperzine A

Each ingredient & the kinds of drugs it affects

For each ingredient in Huperzine-A with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Huperzine A2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine A full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Huperzine-A, from the product label.

Absonutrix

See all Absonutrix products
Name
Absonutrix
Street Address
8905 West Market Street
City
Colfax
State
NC
ZipCode
27235
Phone Number
1-855-368-8749
Web Address
www.absonutrix.com
Pharmacist Counseling Corner

Huperzine-A by Absonutrix: Common Questions

Does Huperzine-A by Absonutrix interact with any medications?
Yes. Based on its ingredients, Huperzine-A has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Huperzine-A contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is huperzine A and what does it do?
Huperzine A is a compound from toothed clubmoss that blocks an enzyme called acetylcholinesterase. That enzyme normally breaks down acetylcholine, a neurotransmitter involved in memory and thinking. By blocking that enzyme, huperzine A increases acetylcholine in the brain.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advises against it during pregnancy and while breastfeeding. There isn't enough information to know it's safe at those times. Talk with your doctor or pharmacist before considering it.
What side effects might I experience?
Huperzine A can cause dizziness, nausea, and sweating. No adverse effects have been reported in formal trials, but a thorough safety evaluation hasn't been done, so other side effects may exist.
Is this product consistent from bottle to bottle?
Product quality varies widely in this category, so you may notice differences between batches. This is worth keeping in mind if you use it regularly.
Is there evidence this works for memory or brain health?
We don't have effectiveness data on file for this ingredient, so we can't tell you whether it's proven to work. That's a good question to ask your pharmacist or doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Huperzine-A is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Huperzine-A label
Go deeper

The Full Monographs Behind Huperzine-A’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph → Herb & supplement monograph

Toothed Clubmoss

Interacts with 219 drugs

Toothed Clubmoss is a moss-like plant best known as the natural source of huperzine A, a compound studied mainly for memory and Alzheimer's disease. Some early research is promising, but the...

Read the full Toothed Clubmoss monograph →
Sources

Sources & How We Checked

Huperzine-A's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Huperzine A 13 references
  1. Skolnick AA. Old Chinese herbal medicine used for fever yields possible new Alzheimer Disease therapy. JAMA 1997;277:776. DOI
  2. Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.. DOI
  3. Wang T, Tang XC. Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine. Eur J Pharmacol 1998;349:137-42. PubMed
  4. Xu SS, Gao ZX, Weng Z, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao 1995;16:391-5.
  5. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  6. Xu SS, Cai ZY, Qu ZW, et al. Huperzine-A in capsules and tablets for treating patients with Alzheimer disease. Zhongguo Yao Li Xue Bao 1999;20:486-90.
  7. Felgenhauer N, Zilker T, Worek F, Eyer P. Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss. J Toxicol Clin Toxicol 2000;38:803-8.. PubMed
  8. Zhang, Z., Wang, X., Chen, Q., Shu, L., Wang, J., and Shan, G. [Clinical efficacy and safety of huperzine Alpha in treatment of mild to moderate Alzheimer disease, a placebo-controlled, double-blind, randomized trial]. Zhonghua Yi Xue Za Zhi 7-25-2002;82
  9. Cheng, D. H., Ren, H., and Tang, X. C. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport 12-20-1996;8(1):97-101. PubMed
  10. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. J Neural Transm (Vienna) 2009;116(4):457-65. PubMed
  11. Xu ZQ, Liang XM, Juan-Wu, Zhang YF, Zhu CX, Jiang XJ. Treatment with Huperzine A improves cognition in vascular dementia patients. Cell Biochem Biophys 2012;62(1):55-8. PubMed
  12. Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One 2013;8(9):e74916. PubMed
  13. Xing SH, Zhu CX, Zhang R, An L. Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid Based Complement Alternat Med 2014;2014:363985. PubMed

See these in context on the Huperzine A monograph →

Toothed Clubmoss 3 references
  1. Budavari S, ed. The Merck Index. 12th ed. Whitehouse Station, NJ: Merck & Co., Inc., 1996.
  2. Zhang RW, Tang XC, Han YY, et al. [Drug evaluation of huperzine A in the treatment of senile memory disorders]. Chung Kuo Yao Li Hsueh Pao 1991;12:250-2.
  3. Ohba T, Yoshino Y, Ishisaka M, et al. Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice. Biosci Biotechnol Biochem. 2015;79(11):1838-44.

See these in context on the Toothed Clubmoss monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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