Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Hydration + Liver Aid Mixed Berry Ingredients & Drug Interactions

by Zaca

Hydration + Liver Aid Mixed Berry label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hydration + Liver Aid Mixed Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hydration + Liver Aid Mixed Berry is a dietary supplement by Zaca with 4 active ingredients. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Prickly Pear. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Hydration + Liver Aid Mixed Berry by Zaca

Ask about any prescription or over-the-counter medication and we check it for interactions with Hydration + Liver Aid Mixed Berry by Zaca — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Hydration + Liver Aid Mixed Berry by Zaca

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,100 mg) without saying how much of each component you get.

This tablet has 4 active ingredients: a proprietary blend (whose components aren't individually listed), L-Alanyl-L-Glutamine, prickly pear extract, Japanese Raisin tree berry extract, and L-glutathione. The inactive ingredients include xylitol, stearic acid, natural berry flavor, citric acid, beet color, magnesium stearate, silica, and rebaudioside A.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Recovery and hydration support.
  • We looked for evidence on: Hangover, Athletic performance, Electrolyte balance, Physical endurance.
  • The closest evidence on file: Glutathione is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Prickly Pear Cactus is rated "Insufficient Reliable Evidence To Rate" for Hangover.

Prickly pear is possibly effective for diabetes, though the evidence for age-related cognitive decline, prostate health, upset stomach, and cholesterol is not well established. L-Glutathione is possibly effective for certain types of nerve damage from chemotherapy, but evidence for liver health, Alzheimer's disease, athletic performance, and cataracts is insufficient.

We don't have effectiveness data on file for L-Alanyl-L-Glutamine or the proprietary blend's components.

The evidence, ingredient by ingredient Prickly Pear Cactus Glutathione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Prickly pear is generally well tolerated as food, though supplement amounts are less studied. You may experience mild stomach upset (nausea, diarrhea, indigestion, bloating) or, rarely, headache, insomnia, or dizziness.

Cases of bowel obstruction and serious complications from seed ingestion have been reported, but they're extremely rare and tied to eating very large quantities. L-Glutathione appears well tolerated short-term orally, though long-term safety isn't fully clear.

If inhaled, it can narrow airways and cause shortness of breath or cough, especially in people with asthma. Both prickly pear and L-glutathione lack enough safety data in pregnancy and breastfeeding — talk with your doctor or pharmacist before using this product if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Prickly Pear Cactus Glutathione

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Prickly Pear Cactus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check antidiabetes drugs with your doctor or pharmacist — prickly pear may increase the risk of low blood sugar when combined with them. L-Alanyl-L-Glutamine and Japanese Raisin tree extract could not be checked for interactions, so mention them to your healthcare provider too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with hydration and contains ingredients studied for diabetes and liver support, but if you take diabetes medications, you'll need to monitor blood sugar closely because prickly pear can lower it further. Talk with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, have diabetes, or take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hydration + Liver Aid Mixed Berry, straight from the product label.

Brand Zaca
Barcode (UPC) 739189944033
Net contents 2 Chewable Tablet(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 258101
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hydration + Liver Aid Mixed Berry by Zaca, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
1
UPC/BARCODE
739189944033
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Proprietary Blend1100 mg--
L-Alanyl-L-Glutamine0 NP--
Prickly Pear0 NP--
Japanese Raisin tree (Hovenia dulcis) berry extract0 NP--
L-Glutathione0 NP--

Other ingredients: Xylitol, Stearic Acid, natural Berry flavor, Citric Acid, Beet color, Magnesium Stearate, Silica, Rebaudioside A

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Bright-eyed mornings

Sustamine/Setria/Kyowa

Formulation

Recovery chewables

Sugar free GMO free No artificial flavors Gluten free No stimulants

Contains clinically tested ingredients

Vegan

FDA Statement of Identity

Dietary Supplement

General Statements

Party - Travel - Altitude - Exercise

Suggested/Recommended/Usage/Directions

Directions: Take 2 chewables as needed. If drinking, take 4 chewables before bed.

Formula

Pure Ingredients: Japanese Raisin for superior liver detox support L-Alanyl-L-Glutamine enhances electrolytes and hydration Prickly Pear delivers antioxidants and flavonoids L-Glutathione for antioxidant protection, immune fortification & detoxification

Low carb

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store at 59-86 degrees F (15-30 degrees C)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hydration + Liver Aid Mixed Berry by Zaca label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hydration + Liver Aid Mixed Berry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hydration + Liver Aid Mixed Berry by Zaca

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container1 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1100 mg per serving

Other (inactive) ingredients: Xylitol, Stearic Acid, Natural Berry flavor, Citric Acid, Beet color, Magnesium Stearate, Silica, Rebaudioside A. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hydration + Liver Aid Mixed Berry by Zaca Drug Interactions

Want to check YOUR meds against Hydration + Liver Aid Mixed Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Prickly Pear 86

Individual Drug Interactions

The ingredients in Hydration + Liver Aid Mixed Berry interact with 86 drugs. Click any drug to see the details.

1 of the 4 ingredients in Hydration + Liver Aid Mixed Berry interact with drugs. Each result below shows which ingredient is responsible. Prickly Pear

Each ingredient & the kinds of drugs it affects

For each ingredient in Hydration + Liver Aid Mixed Berry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Prickly Pear1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D
Prickly Pear full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hydration + Liver Aid Mixed Berry, from the product label.

Zaca

See all Zaca products
Name
Zaca
Street Address
191 University Blvd. #503
City
Denver
State
CO
ZipCode
80206
Web Address
www.zaca.com
Pharmacist Counseling Corner

Hydration + Liver Aid Mixed Berry by Zaca: Common Questions

Does Hydration + Liver Aid Mixed Berry by Zaca interact with any medications?
Yes. Based on its ingredients, Hydration + Liver Aid Mixed Berry has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hydration + Liver Aid Mixed Berry contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have type 2 diabetes?
Not without talking to your doctor first. Prickly pear in this product may lower blood sugar, and combining it with your diabetes medications could push your levels too low. Your doctor can help you decide if it's right for you and how to monitor yourself safely.
Is it safe to take while pregnant or breastfeeding?
The facts show there isn't enough safety data for prickly pear or L-glutathione during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice — they can help you weigh the risks and benefits for your situation.
What side effects might I experience?
Most people tolerate it well, but you may have mild stomach upset like nausea, diarrhea, indigestion, or bloating. Rarely, some people report headache, insomnia, or dizziness. Stop taking it and call your doctor if side effects are bothersome or don't improve.
Does this actually help with liver health?
L-glutathione is studied for nonalcoholic fatty liver disease, but the evidence isn't strong enough to rate it yet. We don't have effectiveness information on the other ingredients for liver support, so the liver-aid claim isn't backed by established evidence in our data.
Why do I need to check my medications with you?
We have interaction data for 86 medications overall from this product's ingredients. Use the search tool on this page to see if any of your exact drugs are on that list, then share the results with your doctor or pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hydration + Liver Aid Mixed Berry is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hydration + Liver Aid Mixed Berry label
Go deeper

The Full Monographs Behind Hydration + Liver Aid Mixed Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Prickly Pear Cactus

Interacts with 86 drugs

Prickly pear cactus is a desert plant whose pads and fruit are eaten as food and taken as a supplement, mainly for blood sugar, cholesterol, and hangover symptoms. Some small studies suggest...

Read the full Prickly Pear Cactus monograph → Herb & supplement monograph

Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...

Read the full Glutathione monograph →
Sources

Sources & How We Checked

Hydration + Liver Aid Mixed Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Glutathione 1 reference
  1. Marrades RM, Roca J, Barbera JA, et al. Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156(2 Pt 1):425-30. PubMed

See these in context on the Glutathione monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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