Interactions on record — worth a quick check against your medications. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Inflamase Ingredients & Drug Interactions

by Progressive Professional from Progressive Laboratories

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Inflamase is a dietary supplement by Progressive Professional from Progressive Laboratories with 8 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Inflamase by Progressive Professional from Progressive Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • “Gastric Release Phase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Enteric Release Phase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Inflamase has 8 active ingredients: bromelain, lipase, amylase, pancreatin, trypsin, catalase, super oxide dismutase, and panc-zyme enzyme complex. Bromelain is a protein-digesting enzyme from pineapple; lipase, amylase, pancreatin, and trypsin are digestive enzymes that help break down fats, carbohydrates, and proteins; catalase and super oxide dismutase are enzymes that combat oxidative stress in the body.

The product also contains inactive ingredients—gelatin, stearic acid, microcrystalline cellulose, and magnesium stearate—which are common capsule fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Inflammation and swelling support.
  • We looked for evidence on: Allergic rhinitis (hay fever), Exercise-induced muscle soreness, Knee pain, Osteoarthritis, Postoperative pain, Postoperative swelling — and 4 related terms.
  • The closest evidence on file: Trypsin is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Trypsin is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Wound healing, Sprains, Postoperative swelling.
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever), Exercise-induced muscle soreness.

The evidence on whether these enzymes work for their intended purposes isn't established in the data we hold. Bromelain shows insufficient reliable evidence for allergic rhinitis, burns, cancer, chemotherapy-related nerve damage, chronic venous insufficiency, and diabetes.

Lipase and trypsin also have insufficient reliable evidence for their listed uses—dyspepsia (indigestion), inflammatory bowel disease, sprains, osteoarthritis, radiation skin damage, wound healing, exercise soreness, and multiple sclerosis. That means the research so far hasn't been strong enough to say whether they actually help.

The evidence, ingredient by ingredient Bromelain Lipase Trypsin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated in the short term, but long-term safety data is limited. The most common side effects when taken by mouth are diarrhea, flatulence, stomach upset, and headache.

Allergic reactions (hives, itching) can happen, and in rare cases, if bromelain is inhaled at work, it may trigger asthma or throat and eye irritation. Lipase has no reported adverse effects in adults, though safety data is thin.

Trypsin can cause mild to moderate stomach symptoms like nausea, heartburn, and stomach pain when taken by mouth, and localized burning if applied to skin. Pregnancy safety data is not strong enough for bromelain or trypsin—the facts advise against use.

For lipase, there isn't enough data to know either way, so talk with your doctor or pharmacist. Breastfeeding safety is unknown for all three.

Side effects, ingredient by ingredient Bromelain Lipase Trypsin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Inflamase, double-check with us if you're on blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.)—bromelain may increase bleeding risk. Also check if you're on tetracycline antibiotics, though the interaction is less certain.

For any other prescription medications, use the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Inflamase may help with digestion and inflammation, but the evidence isn't strong enough to say for certain. If you take blood thinners, antiplatelet drugs, or tetracycline antibiotics, you'll want to check with us before starting this—bromelain carries a real interaction risk.

Pregnant or breastfeeding? Talk to your pharmacist or doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Inflamase, straight from the product label.

Brand Progressive Professional from Progressive Laboratories
Barcode (UPC) 351821009759
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 261781
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Inflamase by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
351821009759
IngredientAmount% DV
Bromelain100 mcg--
Lipase10 mg--
Amylase10 mg--
Pancreatin100 mg--
Trypsin200 mg--
Catalase100 mcg--
Super Oxide Dismutase100 mcg--
Gastric Release Phase0 NP--
Enteric Release Phase0 NP--
Panc-Zyme Enzyme Complex2 mg--

Other ingredients: Gelatin, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: One capsule twice daily taken between meals, or more, as directed by a health care professional.

Precautions

Pregnant and/or lactating women should consult their physician prior to use.

Caution: Do not take if stomach or duodenal ulcer condition exists.

Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.

Keep out of reach of children.

Formulation

The two-phase pH sensitive release of these ingredients is due to their exclusive enteric matrix formulation.

Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)

General Statements

Sold only for dispensing by a licensed health care professional.

Seals/Symbols

GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111

Brand IP Statement(s)

Progressive Professional from Progressive Laboratories

Formula

Two phase Gastric and enteric release Enzyme capsule

FDA Statement of Identity

Dietary Supplement

See for yourself

Inflamase by Progressive Professional from Progressive Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Inflamase by Progressive Professional from Progressive Laboratories

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gastric Release Phase

0 NP per serving
  • Bromelain
  • › Catalase
  • › Super Oxide Dismutase

Enteric Release Phase

0 NP per serving
  • Lipase
  • › Amylase
  • › Pancreatin
  • Trypsin
  • › Panc-Zyme Enzyme Complex

Other (inactive) ingredients: Gelatin, Stearic Acid, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Inflamase by Progressive Professional from Progressive Laboratories Drug Interactions

Want to check YOUR meds against Inflamase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Each ingredient & the kinds of drugs it affects

For each ingredient in Inflamase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Inflamase, from the product label.

Progressive Professional from Progressive Laboratories

See all Progressive Professional from Progressive Laboratories products
Name
Progressive Laboratories, Inc.
City
Irving
State
Texas
ZipCode
75038
Phone Number
1-800-527-9512
Pharmacist Counseling Corner

Inflamase by Progressive Professional from Progressive Laboratories: Common Questions

Does Inflamase by Progressive Professional from Progressive Laboratories interact with any medications?
Yes. Based on its ingredients, Inflamase has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Inflamase contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does bromelain do in this product?
Bromelain is a protein-digesting enzyme from pineapple that's included to help with digestion and reduce inflammation. We don't have strong evidence yet that it works for specific conditions, but it's the active ingredient most likely to interact with your medications.
Can I take Inflamase if I'm pregnant?
Bromelain and trypsin don't have enough safety data in pregnancy, so the safety data advises against them during pregnancy. Lipase doesn't have clear data either—talk with your doctor or pharmacist about whether it's right for you.
What are the most common side effects?
When taken by mouth, bromelain most often causes diarrhea, flatulence, stomach upset, or headache. Trypsin may cause mild to moderate nausea, heartburn, or stomach pain. Lipase hasn't had reported adverse effects in adults, though safety data is limited.
Is this safe to take long-term?
Bromelain is generally well tolerated in the short term, but we don't have strong evidence on long-term safety. Lipase and trypsin also have limited long-term data. If you're thinking about taking this regularly, check with your pharmacist.
Can I take this while breastfeeding?
Safety while breastfeeding is unknown for all three of the main ingredients here—bromelain, lipase, and trypsin. Talk with your doctor or pharmacist before using it.
Does this product have any fillers?
Yes, it contains inactive ingredients: gelatin, stearic acid, microcrystalline cellulose, and magnesium stearate, which are common binders and capsule materials.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Inflamase is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Inflamase label
Sources

Sources & How We Checked

Inflamase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Trypsin 17 references
  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. PubMed
  3. Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
  4. Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp
  5. Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34. PubMed
  6. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  7. Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372. PubMed
  8. Bolten WW, Glade MJ, Raum S, Ritz BW. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis 2015;2015:251521. PubMed
  9. US Department of Justice. U.S. Files Complaint Against Texas-Based Healthpoint Ltd. Under the False Claims Act. https://www.justice.gov/opa/pr/us-files-complaint-against-texas-based-healthpoint-ltd-under-false-claims-act. (Accessed June 19, 2019).
  10. Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. PubMed
  11. Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. PubMed
  12. Gujral MS, Patnaik PM, Kaul R, et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol. 2001;47 Suppl:S23-8. PubMed
  13. Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. PubMed
  14. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. PubMed
  15. Popiela T, Kulig J, Klek S, Wachol D, Bock PR, Hanisch J. Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer. Przegl Lek. 2000;57 Suppl 5:142.
  16. Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac S PubMed
  17. Comparison of Chronic Wound Care Products. Pharmacist's Letter/Prescriber's Letter 2008;12(3):1203.

See these in context on the Trypsin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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