GSC Ingredients & Drug Interactions
by Progressive Professional from Progressive Laboratories
What is this page for?
First and foremost: checking GSC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
GSC is a dietary supplement by Progressive Professional from Progressive Laboratories with 6 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 23 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Vitamin B12, raw Liver Concentrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against GSC by Progressive Professional from Progressive Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with GSC by Progressive Professional from Progressive Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of GSC by Progressive Professional from Progressive Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 6 active ingredients: vitamin B12 (a B vitamin your body needs to make red blood cells and keep your nerves working), raw adrenal concentrate, raw thymus concentrate, raw spleen concentrate, raw liver concentrate (which contains nutrients and compounds from animal organs), and raw stomach concentrate. The capsules also contain inactive ingredients — rice flour, gelatin, and vegetable lubricant — which help hold and deliver the actives.
Does it work?
Strong evidence
Vitamin B12 in this product is effective for treating B12 deficiency and Imerslund-Grasbeck disease (a rare inherited condition that affects B12 absorption). It's likely effective for cyanide poisoning and possibly effective for canker sores and postherpetic neuralgia (nerve pain after shingles).
The liver extract shows insufficient reliable evidence for hepatitis C and possibly ineffective for chronic fatigue syndrome based on the data we hold. We don't have established effectiveness ratings for the other organ concentrates in this formulation.
How safe is it?
Well-documented data
Vitamin B12 is generally very well tolerated — your body removes excess through your urine, so there's no established upper limit. It's considered safe and is actually needed during both pregnancy and breastfeeding at normal recommended amounts.
The most common side effect from B12 is injection site reactions when given as a shot; oral forms rarely cause allergic reactions like rash or itching. Liver extract carries more caution: it can deliver high levels of vitamin A and iron, and because it comes from raw animal liver, there's concern about source quality and possible contamination.
Liver products should be avoided in pregnancy unless your doctor specifically advises it, due to the risk of excess vitamin A to a developing baby. For breastfeeding, safety hasn't been well studied.
Talk with your doctor or pharmacist before taking this product, especially if you're pregnant or nursing.
Meds to double-check
Minor interactions only
Before you start, double-check with your doctor or pharmacist if you take metformin (for diabetes), warfarin or other blood thinners (for clotting), or iron supplements or iron-containing medications — all have minor documented interactions with ingredients in this product. No interactions are documented for the other organ concentrates we could not check.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
This product may be worth considering if you have low B12 and want organ-concentrate support, but you'll want to check it with your doctor or pharmacist first — particularly if you take metformin for diabetes, warfarin or other blood thinners, or iron supplements. Liver extract raises some sourcing and contamination concerns that are worth discussing.
Your healthcare provider can tell you whether it's right for you and your medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about GSC, straight from the product label.
| Brand | Progressive Professional from Progressive Laboratories |
|---|---|
| Barcode (UPC) | 351821004440 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 11, 2022 |
| DSLD ID | 261235 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for GSC by Progressive Professional from Progressive Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B12 | 24 mcg | 400% |
| raw Adrenal Concentrate | 15 mg | -- |
| raw Thymus Concentrate | 60 mg | -- |
| raw Spleen Concentrate | 15 mg | -- |
| raw Liver Concentrate | 15 mg | -- |
| raw Stomach Concentrate | 15 mg | -- |
Other ingredients: Rice Flour, Gelatin, Vegetable Lubricant
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: One capsule three times daily, or more, as directed a health care professional.
General Statements
Sold only for dispensing by a licensed health care professional.
Precautions
Not to be used by pregnant or lactating women.
Tamper evident band around cap and seal on bottle. Do not use if either seal is broken or missing.
Keep out of reach of children.
Formulation
The glandular material in this product is produced by a special process that does not exceed physiological temperature (37 degrees C)
Guaranteed free of chemical pepticides and synthetic hormones. Contains no sugar, artificial color, preservatives, yeast, corn, wheat, or soy.
Progressive Laboratories manufactured this product in its 3rd party GMP-inspected facility. (Good Manufacturing Practices)
Glandular stress complex
Seals/Symbols
GMP Good Manufacturing Practice Certified GMP Compliant 21 CFR 111
Brand IP Statement(s)
Progressive Professional from Progressive Laboratories
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
GSC by Progressive Professional from Progressive Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in GSC by Progressive Professional from Progressive Laboratories
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin B12
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Vitamin B12 monograph & interactionsRaw Adrenal Concentrate
Raw Thymus Concentrate
Raw Spleen Concentrate
Raw Liver Concentrate
Interacts with3 drugs
Liver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once...
Raw Liver Concentrate monograph & interactionsRaw Stomach Concentrate
Other (inactive) ingredients: Rice Flour, Gelatin, Vegetable Lubricant. These complete the product’s ingredient list but are not active constituents.
GSC by Progressive Professional from Progressive Laboratories Drug Interactions
HelloPharmacist Interaction Report
GSC by Progressive Professional from Progressive Laboratories contains vitamin B12 and liver extract, both of which have documented interactions with medications.
The most serious concern is with vitamin B12 and metformin, a common diabetes medication: metformin can lower B12 levels by interfering with how your body absorbs it in the digestive system, though this is a minor interaction.
Read the full breakdown — every affected drug type, severity by severity
Liver extract may interact with warfarin (a blood thinner) and iron supplements or medications. Liver extract contains small amounts of vitamin K, which theoretically could reduce warfarin's effectiveness if you start, stop, or significantly change how much you take — though this hasn't been directly studied in humans.
Additionally, because liver extract contains natural iron (heme iron), taking it alongside iron supplements or iron-containing medications could increase your total iron intake, raising the risk of stomach upset or iron buildup, especially at higher doses or with long-term use.
We could not check three other ingredients in this product: raw adrenal concentrate, raw thymus concentrate, raw spleen concentrate, and raw stomach concentrate — we hold no interaction data for them. Use the search tool on this page to verify all your specific medications against these ingredients before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against GSC?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in GSC interact with 23 drugs. Click any drug to see the details.
2 of the 6 ingredients in GSC interact with drugs. Each result below shows which ingredient is responsible. Vitamin B12 raw Liver Concentrate
Alogliptin, MetforminKazano
How Alogliptin, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Alogliptin, Metformin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Canagliflozin, Metformin Hydrochloride interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Dapagliflozin Propanediol, Metformin interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Empagliflozin, Metformin Hydrochloride interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Ertugliflozin, Metformin Hydrochloride interactionFerrous SulfateFeosol
How Ferrous Sulfate interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Raw Liver ConcentrateIron Minor
Interaction Summary
Liver extract can contain heme iron.
Read the full Raw Liver Concentrate + Ferrous Sulfate interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Glipizide, Metformin interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Glyburide, Metformin interactionLinagliptin, Metformin HydrochlorideJentadueto XR
How Linagliptin, Metformin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Linagliptin, Metformin Hydrochloride interactionMetforminGlucophage, Metformin
How Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin interactionMetformin HydrochlorideRiomet ER
How Metformin Hydrochloride interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin Hydrochloride interactionMetformin, LinagliptinJentadueto
How Metformin, Linagliptin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin, Linagliptin interactionMetformin, RosiglitazoneAvandamet
How Metformin, Rosiglitazone interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin, Rosiglitazone interactionMetformin, SitagliptinJanumet, Janumet XR
How Metformin, Sitagliptin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Metformin, Sitagliptin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Saxagliptin, Metformin Xr interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Sitagliptin, Metformin interactionWarfarinWarfarin
How Warfarin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Raw Liver ConcentrateWarfarin (coumadin) Minor
Interaction Summary
Liver extract products may contain small and variable amounts of vitamin K.
Read the full Raw Liver Concentrate + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Raw Liver ConcentrateWarfarin (coumadin) Minor
Interaction Summary
Liver extract products may contain small and variable amounts of vitamin K.
Read the full Raw Liver Concentrate + Warfarin Sodium interactionPioglitazone, MetforminActoPlus Met
How Pioglitazone, Metformin interacts with GSC — through 1 ingredient. Tap an ingredient for the detail:
Vitamin B12Metformin (glucophage) Minor
Interaction Summary
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.
Read the full Vitamin B12 + Pioglitazone, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in GSC with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin B12
Metformin (Glucophage)
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.
raw Liver Concentrate
Iron
Liver extract can contain heme iron. Taking liver extract with iron-containing medications or supplements may increase total iron intake and could increase the risk of gastrointestinal adverse effects or excessive iron accumulation. The risk is greater with high doses, prolonged use, or in individuals with hemochromatosis or another iron-overload disorder. Review the iron content of the liver extract and the total elemental iron dose. Avoid unnecessary duplicate iron supplementation and consider monitoring ferritin and transferrin saturation when clinically appropriate.
Warfarin (Coumadin)
Liver extract products may contain small and variable amounts of vitamin K. Theoretically, starting, stopping, or substantially changing the amount of liver extract used could reduce the anticoagulant effect of warfarin and lower the INR. However, this interaction has not been directly studied or reported in humans, and the vitamin K content of liver extract products is generally not standardized. Consider monitoring the INR after a meaningful change in liver extract use.
Brand information
Manufacturer and brand details for GSC, from the product label.
Progressive Professional from Progressive Laboratories
See all Progressive Professional from Progressive Laboratories products- Name
- Progressive Laboratories, Inc.
- City
- Irving
- State
- Texas
- ZipCode
- 75038
- Phone Number
- 1-800-527-9512
GSC by Progressive Professional from Progressive Laboratories: Common Questions
Does GSC by Progressive Professional from Progressive Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What is B12 actually used for?
Does this product have any side effects?
What are these organ concentrates supposed to do?
Is B12 safe if I take it long-term?
Will this interact with my blood thinner?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if GSC is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind GSC’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin B12
Interacts with 20 drugsVitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...
Read the full Vitamin B12 monograph → Herb & supplement monographLiver Extract
Interacts with 3 drugsLiver extract is a dried or concentrated form of animal liver that is naturally rich in iron, vitamin B12, vitamin A, and other nutrients. It was once used to treat certain anemias before pu...
Read the full Liver Extract monograph →Sources & How We Checked
GSC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 34 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B12 30 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
- Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
- Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
- Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
- Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
- Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
- Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
- Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
- Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
- Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
- Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
- Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
- Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
- Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
- Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
- Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
- Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
- Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
- Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
- Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
- Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
- Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
- Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
- Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
- Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
- Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
- Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed
Liver Extract 4 references
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med 1989;149:2501-3. DOI
- Ebinuma, H., Saito, H., Tada, S., Masuda, T., Kamiya, T., Nishida, J., Yoshioka, M., and Ishii, H. Additive therapeutic effects of the liver extract preparation mixture adelavin-9 on interferon-beta treatment for chronic hepatitis C. Hepatogastroenterolog
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