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Dietary supplement

Inosine 500 mg Ingredients & Drug Interactions

by Cardiovascular Research

Inosine 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Inosine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Inosine 500 mg is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for athletic performance and energy, multiple sclerosis (raising uric acid), parkinson's disease (raising uric acid).Based on those ingredients, 9 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Inosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Inosine 500 mg by Cardiovascular Research

Ask about any prescription or over-the-counter medication and we check it for interactions with Inosine 500 mg by Cardiovascular Research — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Inosine 500 mg by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: inosine 500 mg per capsule. Inosine is a naturally occurring compound involved in energy metabolism and cell function.

The capsule also contains inactive ingredients (gelatin, silicon dioxide, and magnesium stearate) that serve as filler and binder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Physiological agent for human metabolism.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence isn't established in the data we hold. Inosine has been studied for several conditions—amyotrophic lateral sclerosis (ALS), athletic performance, cancer, diabetic nerve damage, and multiple sclerosis—but reliable evidence to rate its effectiveness for any of these is insufficient.

If you're considering it for a specific condition, talk it over with your doctor about what the research actually shows.

The evidence, ingredient by ingredient Inosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Inosine is generally well tolerated when taken by mouth, but it raises uric acid levels, which is a real concern if you have gout or kidney problems. The most common adverse effects are high uric acid in the blood (hyperuricemia), kidney stones, and uric acid crystals in the urine.

Serious but rare effects include high blood pressure and kidney dysfunction. Kidney stones happened more often when inosine was taken with calcium supplements, and doses of 1–2 grams daily have caused acute kidney pain in some people with multiple sclerosis and reversible drops in kidney function.

There isn't enough safety data to use this during pregnancy, so it should be avoided. Safety while breastfeeding is unknown, so avoid use then as well.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking inosine.

Side effects, ingredient by ingredient Inosine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Inosine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 9 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antigout drugs are the one medication type with a documented moderate interaction: inosine may reduce their effectiveness by raising your uric acid levels. If you take medications to prevent or treat gout, check with your doctor or pharmacist before starting this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a single ingredient with limited evidence for the conditions it's been studied in and a documented moderate interaction with antigout medications. If you have gout, kidney disease, or take any medications for gout, you need to clear this with your doctor or pharmacist first.

The same goes if you're on calcium supplements. Anyone considering inosine should discuss the limited evidence and uric acid concerns with their own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Inosine 500 mg, straight from the product label.

Brand Cardiovascular Research
Barcode (UPC) 696859131561
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 304398
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Inosine 500 mg by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
696859131561
IngredientAmount% DV
Inosine500 mg--

Other ingredients: Gelatin, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Inosine is an individually resolved physiological agent which plays an important role in human metabolism.

Formulation

This product is free of corn, soy, yeast, wheat and other common food allergens.

Gluten free, casein free

Precautions

Caution: If you are pregnant or nursing, have kidney stones or gout, consult a physician prior to taking products.

Suggested/Recommended/Usage/Directions

Directions Take one capsule daily, or as directed by a physician.

General Statements

Ecological Formulas

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Inosine 500 mg by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Inosine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Inosine 500 mg by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Inosine

Interacts with
9 drugs
500 mg per serving

Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athleti...

Inosine monograph & interactions

Other (inactive) ingredients: Gelatin, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Inosine 500 mg by Cardiovascular Research Drug Interactions

Want to check YOUR meds against Inosine 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
9Drugs
9 Moderate

Ingredients driving the most interactions

Inosine 9

Individual Drug Interactions

The ingredients in Inosine 500 mg interact with 9 drugs. Click any drug to see the details.

1 of the 1 ingredient in Inosine 500 mg interact with drugs. Each result below shows which ingredient is responsible. Inosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Inosine 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Inosine1 drug type · 9 drugs

Antigout Drugs

Inosine might reduce the effects of antigout medications.
Inosine increases uric acid levels in the serum and urine, potentially resulting in hyperuricemia and reducing the effects of medications used for the prevention and treatment of gout.

Likelihood Possible Evidence D
Inosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Inosine 500 mg, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
Cardiovascular Research, LTD.
Street Address
1061-B Shary Circle
City
Concord
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Inosine 500 mg by Cardiovascular Research: Common Questions

Does Inosine 500 mg by Cardiovascular Research interact with any medications?
Yes. Based on its ingredients, Inosine 500 mg has a known interaction with 9 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Inosine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will inosine help with athletic performance?
The evidence isn't established in the data we hold. Inosine has been studied for athletic performance, but we don't have reliable evidence yet to say whether it works.
What's the risk with my kidneys?
Inosine raises uric acid levels, and this can lead to kidney stones and uric acid crystals in your urine. The risk is higher if you also take calcium supplements. Rare serious effects include kidney dysfunction. If you have any kidney problems, talk with your doctor before starting.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data to recommend inosine during pregnancy, so it should be avoided. Safety while breastfeeding is unknown, so avoid use then too. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist.
Are there any common side effects?
Inosine is generally well tolerated, but the most common adverse effects are high uric acid levels in your blood and urine, kidney stones, and uric acid crystals. These are directly related to what the supplement does in your body.
Can I take this with a calcium supplement?
Kidney stones occurred more often when inosine was taken with calcium supplements. If you take calcium, check with your pharmacist or doctor before adding inosine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Inosine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Inosine 500 mg label
Go deeper

The Full Monographs Behind Inosine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inosine

Interacts with 9 drugs

Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athletic performance. Solid evidence that it bo...

Read the full Inosine monograph →
Sources

Sources & How We Checked

Inosine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inosine 7 references
  1. Parkinson Study Group SURE-PD Investigators. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014;71(2):141-50.
  2. Muñoz García D, Midaglia L, Martinez Vilela J, et al. Associated inosine to interferon: results of a clinical trial in multiple sclerosis. Acta Neurol Scand. 2015;131(6):405-10. PubMed
  3. Gonsette RE, Sindic C, D'hooghe MB, et al. Boosting endogenous neuroprotection in multiple sclerosis: The association of inosine and interferon beta in relapsing-remitting Multiple Sclerosis (ASIIMS) trial. Mult Scler. 2010;16(4):455-62.
  4. Markowitz CE, Spitsin S, Zimmerman V, et al. The treatment of multiple sclerosis with inosine. J Altern Complement Med. 2009;15(6):619-25. PubMed
  5. Watanabe H, Hattori T, Kume A, et al. Improved Parkinsons disease motor score in a single-arm open-label trial of febuxostat and inosine. Medicine (Baltimore) 2020;99(35):e21576. PubMed
  6. Parkinson Study Group SURE-PD3 Investigators, Schwarzschild MA, Ascherio A, et al. Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial. JAMA 2021;326(10):926-939.
  7. Walk D, Nicholson K, Locatelli E, et al. Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis. Muscle Nerve 2023;67(5):378-386. PubMed

See these in context on the Inosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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