Major interaction on record — check this product against your medications before combining. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

IGA+Intercellular Glutathione Inducers Ingredients & Drug Interactions

by Ecological Formulas

IGA+Intercellular Glutathione Inducers label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking IGA+Intercellular Glutathione Inducers against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

IGA+Intercellular Glutathione Inducers is a dietary supplement by Ecological Formulas with 10 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 445 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are N-Acetyl-L-Cysteine, Lipoic Acid, L-Carnosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against IGA+Intercellular Glutathione Inducers by Ecological Formulas

Ask about any prescription or over-the-counter medication and we check it for interactions with IGA+Intercellular Glutathione Inducers by Ecological Formulas — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of IGA+Intercellular Glutathione Inducers by Ecological Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

IGA+Intercellular Glutathione Inducers contains 10 active ingredients designed to support your body's natural antioxidant defenses. The formula includes L-glycine, L-glutamic acid, L-carnosine, N-acetyl-L-cysteine (NAC), selenomethionine, inosine, lipoic acid (also called alpha-lipoic acid), ornithine alpha ketoglutarate, reduced glutathione, and glyceryl-L-glutamine.

These amino acids and their derivatives are believed to work together to help your cells produce and maintain glutathione, a powerful antioxidant your body makes naturally. The capsules also contain inactive ingredients — gelatin, cellulose, silicon dioxide, and magnesium stearate — which serve as the capsule shell and binding agents.

There are no added fillers beyond these standard inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: glutathione synthesis support.
  • We looked for evidence on: Acetaminophen poisoning, Acute respiratory distress syndrome (ARDS), Alcohol-related liver disease, Alzheimer disease, Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), Asthma — and 4 related terms.
  • The strongest evidence on file: N-acetyl Cysteine (nac) is rated "Effective" for Acetaminophen poisoning (Natural Medicines).
  • Also on file: Ornithine is rated "Possibly Effective" for Athletic performance.
  • Also on file: N-acetyl Cysteine (nac) is rated "Possibly Effective" for Bronchitis.

Evidence for most uses of the individual ingredients in this product is limited or mixed. L-glycine is possibly effective for schizophrenia, though the other conditions it's studied for (ADHD, benign prostatic hyperplasia, cystic fibrosis, and a rare genetic disorder) don't yet have enough reliable evidence.

L-carnosine is possibly ineffective for autism spectrum disorder, and evidence is insufficient for its use in age-related cognitive decline, Alzheimer's, athletic performance, cataracts, and cognitive impairment. N-acetyl-L-cysteine is effective for acetaminophen (Tylenol) poisoning and certain respiratory or medical procedures, and possibly effective for bronchitis.

Lipoic acid is possibly effective for diabetic nerve pain, high cholesterol, and weight management. Inosine, ornithine alpha ketoglutarate, reduced glutathione, and the ingredients we couldn't fully assess don't yet have solid evidence supporting specific health claims in the data we hold.

The evidence, ingredient by ingredient Glycine Carnosine N-acetyl Cysteine (nac) Inosine Alpha-lipoic Acid Ornithine Glutathione

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the individual ingredients are generally well tolerated at typical doses, though long-term safety data are limited for several of them. Possible side effects include mild sedation, irritability, insomnia, fatigue, memory issues, headache, nausea, vomiting, diarrhea, dry mouth, heartburn, and loss of appetite.

N-acetyl-L-cysteine may cause joint pain or leg pain in some people. Inosine raises uric acid levels and can cause kidney stones and uric acid crystals in the urine; people with gout or kidney disease should be especially cautious.

Lipoic acid can lower blood sugar, so it's best used under medical guidance if you take diabetes medications. Inhaled glutathione can narrow airways and cause shortness of breath in people with asthma.

For pregnancy and breastfeeding, there isn't enough safety data for most of these ingredients to give clear guidance. L-carnosine should be avoided during pregnancy and breastfeeding.

Inosine, lipoic acid, and ornithine alpha ketoglutarate should also be avoided during pregnancy and breastfeeding due to insufficient safety information. N-acetyl-L-cysteine is rated possibly safe in pregnancy but should be discussed with your doctor.

There's no pregnancy/lactation safety data on file for L-glycine, reduced glutathione, or the three ingredients we could not check. Talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Glycine Carnosine N-acetyl Cysteine (nac) Inosine Alpha-lipoic Acid Ornithine Glutathione

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Inosine, Alpha-lipoic Acid, N-acetyl Cysteine (nac), Carnosine, Glycine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 445 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use nitroglycerin, blood thinners or antiplatelet drugs (like warfarin or aspirin), blood pressure medications, diabetes drugs, gout medications, thyroid hormone, or any chemotherapy drugs. These are the medication types with the strongest documented concerns based on the ingredients in this formula.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a complex supplement with multiple ingredients and several documented medication interactions — especially with blood thinners, blood pressure drugs, diabetes medications, and chemotherapy. If you take any prescription medication, anticoagulant, antihypertensive, or diabetes drug, or if you have gout or kidney disease, check your specific medications with the tool on this page before starting.

The evidence for what this product actually does isn't well established in the data we hold. Talk it over with your doctor or pharmacist to see if it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about IGA+Intercellular Glutathione Inducers, straight from the product label.

Brand Ecological Formulas
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22684
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for IGA+Intercellular Glutathione Inducers by Ecological Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
L-Glycine25 mg--
L-Glutamic Acid25 mg--
L-Carnosine2.5 mg--
N-Acetyl-L-Cysteine300 mg--
Selenomethionine50 mcg--
Inosine5 mg--
Lipoic Acid7.5 mg--
Ornithine Alpha Ketoglutarate50 mg--
reduced Glutathione25 mg--
Glyceryl-L-Glutamine5 mg--

Other ingredients: Gelatin, Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

ECOLOGICAL FORMULAS(TM)

General Statements

EXP1012

IGA+ is a scientifically-designed formula containing a complement of synergistic nutrient precursors to glutathione synthesis. Only the purest ingredients are contained in this formula.

FDA Statement of Identity

Dietary Supplement

A DIETARY SUPPLEMENT

Formula

This product is free of corn, soy, yeast, wheat and other common allergens.

Formulation

This product is free of corn, soy, yeast, wheat and other common allergens.

Suggested/Recommended/Usage/Directions

DIRECTIONS Take one or two capsules daily, or as directed by a physician.

FDA Disclaimer Statement

This product has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

General

10040128

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

IGA+Intercellular Glutathione Inducers by Ecological Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

IGA+Intercellular Glutathione Inducers label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in IGA+Intercellular Glutathione Inducers by Ecological Formulas

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glycine

Interacts with
1 drug
25 mg per serving

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...

L-Glycine monograph & interactions

L-Glutamic Acid

25 mg per serving

L-Carnosine

Interacts with
86 drugs
2.5 mg per serving

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is so...

L-Carnosine monograph & interactions

N-Acetyl-L-Cysteine

Interacts with
294 drugs
300 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-L-Cysteine monograph & interactions

Selenomethionine

50 mcg per serving

Inosine

Interacts with
9 drugs
5 mg per serving

Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athleti...

Inosine monograph & interactions

Lipoic Acid

Interacts with
263 drugs
7.5 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Lipoic Acid monograph & interactions

Ornithine Alpha Ketoglutarate

No known
interactions
50 mg per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

Ornithine Alpha Ketoglutarate monograph & interactions

Reduced Glutathione

No known
interactions
25 mg per serving

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefit...

Reduced Glutathione monograph & interactions

Glyceryl-L-Glutamine

5 mg per serving

Other (inactive) ingredients: Gelatin, Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

IGA+Intercellular Glutathione Inducers by Ecological Formulas Drug Interactions

Want to check YOUR meds against IGA+Intercellular Glutathione Inducers?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
445Drugs
1 Major 444 Moderate

Ingredients driving the most interactions

N-Acetyl-L-Cysteine 294
Lipoic Acid 263
L-Carnosine 86
Inosine 9
L-Glycine 1

Individual Drug Interactions

The ingredients in IGA+Intercellular Glutathione Inducers interact with 445 drugs. Click any drug to see the details.

5 of the 10 ingredients in IGA+Intercellular Glutathione Inducers interact with drugs. Each result below shows which ingredient is responsible. N-Acetyl-L-Cysteine Lipoic Acid L-Carnosine Inosine L-Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in IGA+Intercellular Glutathione Inducers with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

N-Acetyl-L-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-L-Cysteine full monograph & interactions

Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Lipoic Acid full monograph & interactions

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
L-Carnosine full monograph & interactions

Inosine1 drug type · 9 drugs

Antigout Drugs

Inosine might reduce the effects of antigout medications.
Inosine increases uric acid levels in the serum and urine, potentially resulting in hyperuricemia and reducing the effects of medications used for the prevention and treatment of gout.

Likelihood Possible Evidence D
Inosine full monograph & interactions

L-Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
L-Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for IGA+Intercellular Glutathione Inducers, from the product label.

Ecological Formulas

See all Ecological Formulas products
Name
ECOLOGICAL FORMULAS
Street Address
1061-B SHARY CIRCLE
City
CONCORD
State
CA
ZipCode
94518
Pharmacist Counseling Corner

IGA+Intercellular Glutathione Inducers by Ecological Formulas: Common Questions

Does IGA+Intercellular Glutathione Inducers by Ecological Formulas interact with any medications?
Yes. Based on its ingredients, IGA+Intercellular Glutathione Inducers has a known interaction with 445 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
IGA+Intercellular Glutathione Inducers contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
No — not without checking first. N-acetyl-L-cysteine in this product may increase bleeding risk when combined with blood thinners. Talk with your doctor or pharmacist about whether this supplement is right for you before starting.
What is N-acetyl-L-cysteine (NAC) in this formula for?
NAC is an amino acid that supports your body's natural defenses and is effective for acetaminophen poisoning and certain respiratory treatments. In this product, it's included as one of several compounds meant to help your cells produce glutathione, a powerful antioxidant.
Can I take this if I'm on medication for diabetes?
Maybe, but check first. Both L-carnosine and lipoic acid in this product may theoretically lower blood sugar, which could increase the risk of hypoglycemia if you're already taking diabetes drugs. Your doctor or pharmacist can tell you whether it's safe for your situation.
Is this safe to take during pregnancy?
There isn't enough safety data for most ingredients in this product during pregnancy. L-carnosine and inosine should be avoided; N-acetyl-L-cysteine is possibly safe but should be discussed with your doctor. Talk with your healthcare provider before taking this product if you're pregnant.
Does this product actually work for anything?
The evidence in our data is limited. NAC is proven effective for acetaminophen poisoning and certain medical procedures. L-glycine is possibly effective for schizophrenia, and lipoic acid is possibly effective for diabetic nerve pain, high cholesterol, and weight management. For most other uses, evidence is insufficient or mixed.
What do the inactive ingredients do?
Gelatin, cellulose, silicon dioxide, and magnesium stearate are standard capsule and binding ingredients. They hold the active ingredients together but don't play an active role in the formula's intended effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

IGA+Intercellular Glutathione Inducers label
Go deeper

The Full Monographs Behind IGA+Intercellular Glutathione Inducers’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph → Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Inosine

Interacts with 9 drugs

Inosine is a nucleoside (a building block of DNA and RNA) that the body makes on its own and is also sold as a supplement, mostly marketed for athletic performance. Solid evidence that it bo...

Read the full Inosine monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Ornithine

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement for fatigue, exercise recovery, and sleep,...

Read the full Ornithine monograph → Herb & supplement monograph

Glutathione

Glutathione is a powerful antioxidant your body makes naturally, and many people take it as a supplement hoping for skin, detox, or anti-aging benefits. However, strong human evidence is lim...

Read the full Glutathione monograph →
Sources

Sources & How We Checked

IGA+Intercellular Glutathione Inducers's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 153 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Carnosine 5 references
  1. Chengappa KN, Turkin SR, DeSanti S, et al. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res 2012;142(1-3):145-52. PubMed
  2. Karkabounas S, Papadopoulos N, Anastasiadou C, et al. Effects of a-lipoic Acid, carnosine, and thiamine supplementation in obese patients with type 2 diabetes mellitus: A randomized, double-blind study. J Med Food. 2018;21(12):1197-1203.
  3. Peng W, Mao P, Liu L, et al. Effect of carnosine supplementation on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a systematic review and meta-analysis of long-term randomized controlled trials. Complement Ther Med 2020;48:102241. PubMed
  4. Siriwattanasit N, Satirapoj B, Supasyndh O. Effect of oral carnosine supplementation on urinary TGF-ß in diabetic nephropathy: a randomized controlled trial. BMC Nephrol 2021;22(1):236. PubMed
  5. Sureshkumar K, Durairaj M, Srinivasan K, et al. Effect of L-Carnosine in Patients with Age-Related Diseases: A Systematic Review and Meta-Analysis. Front Biosci (Landmark Ed) 2023;28(1):18. PubMed

See these in context on the Carnosine monograph →

N-acetyl Cysteine (nac) 86 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994;54:543-7. PubMed
  3. van Zandwijk N, Dalesio O, Pastorino U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung C DOI
  4. Horowitz RS, Dart RC, Jarvie DR, et al. Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol 1997;35:447-51.
  5. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710-5. PubMed
  6. Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med 1994;23:519-23. PubMed
  7. Ardissino D, Merlini PA, Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol 1997;29:941-7. PubMed
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See these in context on the N-acetyl Cysteine (nac) monograph →

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See these in context on the Inosine monograph →

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  43. Izzo V, Greco C, Corradini D, et al. Insulin autoimmune syndrome in an Argentine woman taking a-lipoic acid: A case report and review of the literature. SAGE Open Med Case Rep. 2018;6:2050313X18819601.
  44. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Scientific opinion on the relationship between intake of alpha-lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome. EFSA J 2021;19(6):e06577. PubMed
  45. Jibril AT, Jayedi A, Shab-Bidar S. Efficacy and safety of oral alpha-lipoic acid supplementation for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized trials. Endocr Connect 2022;11(10):e220322. PubMed
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  47. Velasco-Amador JP, Prados-Carmona Á, Navarro-Triviño FJ. Contact urticaria syndrome caused by alpha-lipoic acid in a master formula for vulvar lichen sclerosus. Contact Dermatitis 2023;89(2):136-137. PubMed
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See these in context on the Alpha-lipoic Acid monograph →

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Glutathione 1 reference
  1. Marrades RM, Roca J, Barbera JA, et al. Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156(2 Pt 1):425-30. PubMed

See these in context on the Glutathione monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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