Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Integra-Lean 150 mg Ingredients & Drug Interactions

by Life Extension

Integra-Lean 150 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Integra-Lean 150 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Integra-Lean 150 mg is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for weight loss, appetite control, cholesterol support.Based on those ingredients, 94 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Integra-Lean 150 mg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Integra-Lean 150 mg by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Integra-Lean 150 mg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Integra-Lean contains one active ingredient: African Mango extract (Irvingia gabonensis), supplied at 150 mg per capsule as a proprietary extract. The supplement also includes inactive ingredients — rice flour, vegetable cellulose, vegetable stearate, and silica — which are common capsule fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Irvingia Gabonensis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports weight management and metabolic wellness.
  • We looked for evidence on: Obesity, Metabolic syndrome, Hypercholesterolemia, Diabetes.
  • The closest evidence on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Irvingia Gabonensis is rated "Insufficient Reliable Evidence To Rate" for Hypercholesterolemia, Obesity, Metabolic syndrome.

The evidence for Irvingia gabonensis isn't established enough to rate it reliably. Our data shows insufficient evidence for diabetes, high cholesterol, obesity, or metabolic syndrome.

While some human studies on blood sugar exist (which informed the interaction warnings), they don't establish effectiveness as a treatment. Talk with your doctor if you're considering this for any of these conditions.

The evidence, ingredient by ingredient Irvingia Gabonensis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, Irvingia gabonensis is generally well tolerated short-term, though long-term safety isn't well studied. The most common side effects reported in trials are flatulence, headache, insomnia, and nausea.

One case of acute liver inflammation (hepatitis) has been reported in a user taking 350 mg twice daily; the person developed jaundice and abdominal discomfort within four days. Because of limited long-term safety data, it's best avoided during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Irvingia Gabonensis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Irvingia Gabonensis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 94 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Integra-Lean, check with your doctor or pharmacist if you take antidiabetes drugs (like metformin, insulin, or sulfonylureas) — your blood sugar may drop more than expected and you might need a dose adjustment. Also flag if you're on testosterone therapy, as the supplement may have additive effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Integra-Lean is an African Mango extract with two important medication interactions — it can lower blood sugar further if you take diabetes drugs, and may add to testosterone effects if you're on testosterone therapy. If you're on any of these medications, talk with your doctor or pharmacist before starting.

The evidence for its effectiveness in treating diabetes, obesity, or cholesterol isn't established yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Integra-Lean 150 mg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870129431
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 59065
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Integra-Lean 150 mg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870129431
IngredientAmount% DV
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract150 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Vegetable Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. DIRECTIONS: Take one (1) capsule twice daily with or without food, or as recommended by a healthcare practitioner. This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Precautions

WARNINGS: -Keep out of reach of children.

-DO NOT EXCEED RECOMMENDED DOSE. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition of if you are pregnant or lactating.

General Statements

Scan for product info

Supports Weight Management and Metabolic Wellness*

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

General

Q01294E

Formula

African Mango Irvingia

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Integra-Lean Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending. IGOB-131 proprietary extract is a registered trademark of Gateway Health Alliances, Inc.

Storage

Store tightly closed in a cool, dry place.

Seals/Symbols

Certified Irvingia Authentic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Integra-Lean 150 mg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Integra-Lean 150 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Integra-Lean 150 mg by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract

Interacts with
94 drugs
150 mg per serving

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benef...

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Vegetable Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Integra-Lean 150 mg by Life Extension Drug Interactions

Want to check YOUR meds against Integra-Lean 150 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
94Drugs
94 Moderate

Ingredients driving the most interactions

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract 94

Individual Drug Interactions

The ingredients in Integra-Lean 150 mg interact with 94 drugs. Click any drug to see the details.

1 of the 1 ingredient in Integra-Lean 150 mg interact with drugs. Each result below shows which ingredient is responsible. Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Integra-Lean 150 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract2 drug types · 94 drugs

Antidiabetes Drugs

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.
Human research shows that Irvingia gabonensis decreases blood sugar in diabetic patients being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Testosterone

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.

Likelihood Possible Evidence D
Integra-Lean African Mango (Irvingia gabonensis) Proprietary extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Integra-Lean 150 mg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
Florida
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
www.lef.org
Pharmacist Counseling Corner

Integra-Lean 150 mg by Life Extension: Common Questions

Does Integra-Lean 150 mg by Life Extension interact with any medications?
Yes. Based on its ingredients, Integra-Lean 150 mg has a known interaction with 94 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Integra-Lean 150 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on metformin for type 2 diabetes?
Not without checking with your doctor first. Human research shows Irvingia gabonensis lowers blood sugar on its own, so combining it with metformin or other diabetes drugs increases the risk of low blood sugar. Your doctor may need to adjust your diabetes medication dose or monitor you more closely if you use both.
What side effects have been reported?
The most common ones in studies are flatulence, headache, insomnia, and nausea. One case of liver inflammation was reported in someone taking a higher dose. Since long-term safety data is limited, you should know the risks before starting.
Is this safe to take while pregnant or breastfeeding?
No. The safety data advises against it during pregnancy, and there's not enough information to use it while breastfeeding. Talk with your doctor or pharmacist about safer options if you're pregnant, planning pregnancy, or nursing.
Does this actually work for weight loss or blood sugar?
The evidence isn't solid enough to rate it. While some human studies show it can lower blood sugar in people already on diabetes medications, that's different from proving it works as a treatment on its own. The evidence for weight loss and cholesterol is also insufficient.
I'm on testosterone replacement. Is this safe?
Animal research suggests Irvingia gabonensis raises testosterone levels, so using both together might strengthen each other's effects. Talk with your doctor or pharmacist before adding this supplement to your testosterone therapy.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Integra-Lean 150 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Integra-Lean 150 mg label
Go deeper

The Full Monographs Behind Integra-Lean 150 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Irvingia Gabonensis

Interacts with 94 drugs

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low...

Read the full Irvingia Gabonensis monograph →
Sources

Sources & How We Checked

Integra-Lean 150 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Irvingia Gabonensis 7 references
  1. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  2. Ngondi JL, Etoundi BC, Nyangono CB, et al. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controll
  3. Adamson, I., Okafor, C., and Abu-Bakare, A. A supplement of Dikanut (Irvingia gabonesis) improves treatment of type II diabetics. West Afr.J.Med. 1990;9(2):108-115.
  4. Adamson, I., Okafor, C., and Abu-Bakare, A. Erythrocyte membrane ATPases in diabetes: effect of dikanut (Irvingia gabonensis). Enzyme 1986;36(3):212-215. PubMed
  5. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI
  6. Kilinçalp S, Basar O, Coban S, Yüksel I. Irvingia gabonensis (African mango): innocent magic formula? Acta Gastroenterol Belg 2014;77(1):75-6.
  7. Nonsa-Ard R, Aneknan P, Tong-Un T, Honsawek S, Leelayuwat N. Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals. Nutrients 2022;14(21):4646. PubMed

See these in context on the Irvingia Gabonensis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team